作者：Orthwein, Alexandre; Fradet-Turcotte, Amelie; Noordermeer, Sylvie M.; Canny, Marella D.; Brun, Catherine M.; Strecker, Jonathan; Escribano-Diaz, Cristina; Durocher, Daniel
作者单位：University of Toronto; Sinai Health System Toronto; Lunenfeld Tanenbaum Research Institute; University of Toronto
作者：Pillar, Valerio D.; Overbeck, Gerhard E.
作者单位：Universidade Federal do Rio Grande do Sul; Universidade Federal do Rio Grande do Sul
作者：Lanzarini, Francesca; Maranesi, Monica; Rondoni, Elena Hilary; Albertini, Davide; Ferretti, Elena; Lanzilotto, Marco; Micera, Silvestro; Mazzoni, Alberto; Bonini, Luca
作者单位：University of Parma; Scuola Superiore Sant'Anna; Scuola Superiore Sant'Anna; Scuola Superiore Sant'Anna; Vita-Salute San Raffaele University; Scuola Superiore Sant'Anna; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要：The current understanding of primate natural action organization derives from laboratory experiments in restrained contexts (RCs) under the assumption that this knowledge generalizes to freely moving contexts (FMCs). In this work, we developed a neurobehavioral platform to enable wireless recording of the same premotor neurons in both RCs and FMCs. Neurons often encoded the same hand and mouth actions differently in RCs and FMCs. Furthermore, in FMCs, we identified cells that selectively encod...
作者：Ramos, Raul; Pham, Kim T.; Prince, Richard C.; Leiser-Miller, Leith B.; Prasad, Maneeshi S.; Wang, Xiaojie; Nordberg, Rachel C.; Bielajew, Benjamin J.; Hu, Jerry C.; Yamaga, Kosuke; Oh, Ji Won; Peng, Tao; Datta, Rupsa; Astrowskaja, Aksana; Almet, Axel A.; Burns, John T.; Liu, Yuchen; Guerrero-Juarez, Christian Fernando; Tran, Bryant Q.; Chu, Yi-Lin; Nguyen, Anh M.; Hsi, Tsai-Ching; Lim, Norman T. -L.; Schoeniger, Sandra; Liu, Ruiqi; Pai, Yun-Ling; Vadivel, Chella K.; Ingleby, Sandy; McKechnie, Andrew E.; van Breukelen, Frank; Hoehn, Kyle L.; Rasweiler, John J.; Kohara, Michinori; Loughry, William J.; Weldy, Scott H.; Cosper, Raymond; Yang, Chao-Chun; Lin, Sung-Jan; Cooper, Kimberly L.; Santana, Sharlene E.; Bradley, Jeffrey E.; Kiebish, Michael A.; Digman, Michelle; James, David E.; Merrill, Amy E.; Nie, Qing; Schilling, Thomas F.; Astrowski, Aliaksandr A.; Potma, Eric O.; Garcia-Castro, Martin I.; Athanasiou, Kyriacos A.; Behringer, Richard R.; Plikus, Maksim V.
作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of Washington; University of Washington Seattle; University of California System; University of California Riverside; State University of New York (SUNY) System; University at Buffalo, SUNY; Yonsei University; Yonsei University Health System; Kyungpook National University (KNU); Kyungpook National University (KNU); Kyungpook National University Hospital (KNUH); University of California System; University of California Irvine; University of California System; University of California Irvine; Grodno State Medical University; University of California System; University of California Irvine; Nanyang Technological University; National Institute of Education (NIE) Singapore; Leipzig University; National Taiwan University; National Taiwan University; University of Copenhagen; Australian Museum; University of Pretoria; South African National Biodiversity Institute; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; University of New South Wales Sydney; University at Albany, SUNY; State University of New York (SUNY) System; SUNY Downstate Health Sciences University; Tokyo Metropolitan Institute of Medical Science; University System of Georgia; Valdosta State University; National Cheng Kung University; National Cheng Kung University Hospital; National Cheng Kung University; University of California System; University of California San Diego; University of Washington; University of Washington Seattle; University of California System; University of California Irvine; University of Sydney; University of Sydney; University of Southern California; National Academy of Sciences of Belarus (NASB); Institute of Biochemistry of Biologically Active Compounds of the National Academy of Sciences of Belarus; University of Texas System; UTMD Anderson Cancer Center
摘要：Conventionally, the size, shape, and biomechanics of cartilages are determined by their voluminous extracellular matrix. By contrast, we found that multiple murine cartilages consist of lipid-filled cells called lipochondrocytes. Despite resembling adipocytes, lipochondrocytes were molecularly distinct and produced lipids exclusively through de novo lipogenesis. Consequently, lipochondrocytes grew uniform lipid droplets that resisted systemic lipid surges and did not enlarge upon obesity. Lipo...
