作者：Oberstaller, Jenna; Xu, Shulin; Naskar, Deboki; Zhang, Min; Wang, Chengqi; Gibbons, Justin; Pires, Camilla Valente; Mayho, Matthew; Otto, Thomas D.; Rayner, Julian C.; Adams, John H.
作者单位：State University System of Florida; University of South Florida; University of Cambridge; Wellcome Trust Sanger Institute; University of Glasgow; Universite de Montpellier; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; Institut National de la Sante et de la Recherche Medicale (Inserm); Mahidol University
摘要：Malaria parasites are highly divergent from model eukaryotes. Large-scale genome engineering methods effective in model organisms are frequently inapplicable, and systematic studies of gene function are few. We generated more than 175,000 transposon insertions in the Plasmodium knowlesi genome, averaging an insertion every 138 base pairs, and used this supersaturation mutagenesis to score essentiality for 98% of genes. The density of mutations allowed mapping of putative essential domains with...
作者：Arnon, Inbal; Kirby, Simon; Allen, Jenny A.; Garrigue, Claire; Carroll, Emma L.; Garland, Ellen C.
作者单位：Hebrew University of Jerusalem; University of Edinburgh; University of California System; University of California Santa Cruz; Griffith University; Universite Nouvelle Caledonie; Institut de Recherche pour le Developpement (IRD); University of Auckland; University of St Andrews; University of St Andrews
摘要：Humpback whale song is a culturally transmitted behavior. Human language, which is also culturally transmitted, has statistically coherent parts whose frequency distribution follows a power law. These properties facilitate learning and may therefore arise because of their contribution to the faithful transmission of language over multiple cultural generations. If so, we would expect to find them in other culturally transmitted systems. In this study, we applied methods based on infant speech s...
作者：Whiten, Andrew; Youngblood, Mason
作者单位：University of St Andrews; State University of New York (SUNY) System; Stony Brook University
作者：Gostin, Lawrence O.; Meier, Benjamin Mason
作者单位：Georgetown University; World Health Organization; University of North Carolina; University of North Carolina Chapel Hill
作者：Liu, Hongbo; Abedini, Amin; Ha, Eunji; Ma, Ziyuan; Sheng, Xin; Dumoulin, Bernhard; Qiu, Chengxiang; Aranyi, Tamas; Li, Shen; Dittrich, Nicole; Chen, Hua-Chang; Tao, Ran; Tarng, Der-Cherng; Hsieh, Feng-Jen; Chen, Shih-Ann; Yang, Shun-Fa; Lee, Mei-Yueh; Kwok, Pui-Yan; Wu, Jer-Yuarn; Chen, Chien-Hsiun; Khan, Atlas; Limdi, Nita A.; Wei, Wei-Qi; Walunas, Theresa L.; Karlson, Elizabeth W.; Kenny, Eimear E.; Luo, Yuan; Kottyan, Leah; Connolly, John J.; Jarvik, Gail P.; Weng, Chunhua; Shang, Ning; Cole, Joanne B.; Mercader, Josep M.; Mandla, Ravi; Majarian, Timothy D.; Florez, Jose C.; Haas, Mary E.; Lotta, Luca A.; Drivas, Theodore G.; Vy, Ha My T.; Nadkarni, Girish N.; Wiley, Laura K.; Wilson, Melissa P.; Gignoux, Christopher R.; Rasheed, Humaira; Thomas, Laurent F.; Asvold, Bjrn Olav; Brumpton, Ben M.; Hallan, Stein I.; Hveem, Kristian; Zheng, Jie; Hellwege, Jacklyn N.; Zawistowski, Matthew; Zoellner, Sebastian; Franceschini, Nora; Hu, Hailong; Zhou, Jianfu; Kiryluk, Krzysztof; Ritchie, Marylyn D.; Palmer, Matthew; Edwards, Todd L.; Voight, Benjamin F.; Hung, Adriana M.; Susztak, Katalin
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Zhejiang University; Liangzhu Laboratory; HUN-REN; HUN-REN Research Centre for Natural Sciences; Semmelweis University; Universidade Federal de Sao Paulo (UNIFESP); Vanderbilt University; Vanderbilt University; National Yang Ming Chiao Tung University; Taipei Veterans General Hospital; Academia Sinica - Taiwan; Taichung Veterans General Hospital; National Chung Hsing University; Taipei Veterans General Hospital; National Yang Ming Chiao Tung University; Chung Shan Medical University; Chung Shan Medical University; Chung Shan Medical University Hospital; Kaohsiung Medical University; Kaohsiung Medical University Hospital; Kaohsiung Medical University; Kaohsiung Medical University; University of California System; University of California San Francisco; Columbia University; University of Alabama System; University of Alabama Birmingham; Vanderbilt University; Northwestern University; Feinberg School of Medicine; Northwestern University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Northwestern University; Feinberg School of Medicine; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Washington; University of Washington Seattle; Columbia University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; University of Colorado System; University of Colorado Anschutz Medical Campus; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of Pennsylvania; Vertex Pharmaceuticals; Regeneron; University of Pennsylvania; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado System; University of Colorado Anschutz Medical Campus; Norwegian University of Science & Technology (NTNU); University of Bristol; Norwegian University of Science & Technology (NTNU); Norwegian University of Science & Technology (NTNU); Norwegian University of Science & Technology (NTNU); Norwegian University of Science & Technology (NTNU); Norwegian University of Science & Technology (NTNU); Norwegian University of Science & Technology (NTNU); Shanghai Jiao Tong University; Shanghai Jiao Tong University; Vanderbilt University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of North Carolina; University of North Carolina Chapel Hill; University of Pennsylvania; University of Pennsylvania; Vanderbilt University; University of Pennsylvania; University of Pennsylvania; Vanderbilt University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Tennessee Valley Healthcare System; University of Rochester
摘要：Kidney dysfunction is a major cause of mortality, but its genetic architecture remains elusive. In this study, we conducted a multiancestry genome-wide association study in 2.2 million individuals and identified 1026 (97 previously unknown) independent loci. Ancestry-specific analysis indicated an attenuation of newly identified signals on common variants in European ancestry populations and the power of population diversity for further discoveries. We defined genotype effects on allele-specif...
