6735期

最新文章

• Constrained roads to complex brains AI翻译
  作者：Gattoni, Giacomo; Tosches, Maria Antonietta
  作者单位：Columbia University
• WORKFORCE Retirement-age scientists just keep working AI翻译
  作者：Langin, Katie
• Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer's AI翻译
  作者：Elliott, Carl
  作者单位：University of Minnesota System; University of Minnesota Twin Cities
• SCIENCE POLICY Judge's ruling leaves NIH's move to abruptly slash grants in limbo AI翻译
  作者：Malakoff, David
• Cows get second bird flu virus AI翻译
  作者：Brainard, Jeffrey
• German groups win X data ruling AI翻译
  作者：Brainard, Jeffrey
• Neuroevolution insights into biological neural computation AI翻译
  作者：Miikkulainen, Risto
  作者单位：University of Texas System; University of Texas Austin
  摘要：This article reviews existing work and future opportunities in neuroevolution, an area of machine learning in which evolutionary optimization methods such as genetic algorithms are used to construct neural networks to achieve desired behavior. The article takes a neuroscience perspective, identifying where neuroevolution can lead to insights about the structure, function, and developmental and evolutionary origins of biological neural circuitry that can be studied in further neuroscience exper...
• Developmental origins and evolution of pallial cell types and structures in birds AI翻译
  作者：Zaremba, Bastienne; Fallahshahroudi, Amir; Schneider, Celine; Schmidt, Julia; Sarropoulos, Ioannis; Leushkin, Evgeny; Berki, Bianka; Van Poucke, Enya; Jensen, Per; Senovilla-Ganzo, Rodrigo; Hervas-Sotomayor, Francisca; Trost, Nils; Lamanna, Francesco; Sepp, Mari; Garcia-Moreno, Fernando; Kaessmann, Henrik
  作者单位：Ruprecht Karls University Heidelberg; Helmholtz Association; German Cancer Research Center (DKFZ); Wellcome Trust Sanger Institute; Ruprecht Karls University Heidelberg; Linkoping University; University of Basque Country; Basque Foundation for Science
  摘要：Innovations in the pallium likely facilitated the evolution of advanced cognitive abilities in birds. We therefore scrutinized its cellular composition and evolution using cell type atlases from chicken, mouse, and nonavian reptiles. We found that the avian pallium shares most inhibitory neuron types with other amniotes. Whereas excitatory neuron types in amniote hippocampal regions show evolutionary conservation, those in other pallial regions have diverged. Neurons in the avian mesopallium d...
• Mexico squeezes research budget AI翻译
  作者：Brainard, Jeffrey
• RNA polymerase II at histone genes predicts outcome in human cancer AI翻译
  作者：Henikoff, Steven; Zheng, Ye; Paranal, Ronald M.; Xu, Yiling; Greene, Jacob E.; Henikoff, Jorja G.; Russell, Zachary R.; Szulzewsky, Frank; Thirimanne, H. Nayanga; Kugel, Sita; Holland, Eric C.; Ahmad, Kami
  作者单位：Fred Hutchinson Cancer Center; Howard Hughes Medical Institute; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; University of Texas System; UTMD Anderson Cancer Center; Utah System of Higher Education; University of Utah; Huntsman Cancer Institute
  摘要：Genome-wide hypertranscription is common in human cancer and predicts poor prognosis. To understand how hypertranscription might drive cancer, we applied our formalin-fixed paraffin-embedded (FFPE)-cleavage under targeted accessible chromatin method for mapping RNA polymerase II (RNAPII) genome-wide in FFPE sections. We demonstrate global RNAPII elevations in mouse gliomas and assorted human tumors in small clinical samples and discover regional elevations corresponding to de novo HER2 amplifi...