6736期

最新文章

• Enabling evolvability to evolve AI翻译
  作者：Kussell, Edo
  作者单位：New York University; New York University
• Antiviral signaling of a type III CRISPR-associated deaminase AI翻译
  作者：Li, Yutao; Li, Zhaoxing; Yan, Purui; Hua, Chenyang; Kong, Jianping; Wu, Wanqian; Cui, Yurong; Duan, Yan; Li, Shunxiang; Li, Guanglei; Ji, Shunli; Chen, Yijun; Zhao, Yucheng; Yang, Peng; Hu, Chunyi; Lu, Meiling; Chen, Meirong; Xiao, Yibei
  作者单位：China Pharmaceutical University; China Pharmaceutical University; China Pharmaceutical University; China Pharmaceutical University; Hunan University of Chinese Medicine; Nanjing University of Finance & Economics; China Pharmaceutical University; National University of Singapore; National University of Singapore
  摘要：Prokaryotes have evolved diverse defense strategies against viral infection, including foreign nucleic acid degradation by CRISPR-Cas systems and DNA and RNA synthesis inhibition through nucleotide pool depletion. Here, we report an antiviral mechanism of type III CRISPR-Cas-regulated adenosine triphosphate (ATP) depletion in which ATP is converted into inosine triphosphate (ITP) by CRISPR-Cas-associated adenosine deaminase (CAAD) upon activation by either cA(4) or cA(6), followed by hydrolysi...
• Material-like robotic collectives with spatiotemporal control of strength and shape AI翻译
  作者：Devlin, Matthew R.; Kim, Sangwoo; Campas, Otger; Hawkes, Elliot W.
  作者单位：University of California System; University of California Santa Barbara; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Technische Universitat Dresden; Max Planck Society
  摘要：The vision of robotic materials-cohesive collectives of robotic units that can arrange into virtually any form with any physical properties-has long intrigued both science and fiction. Yet, this vision requires a fundamental physical challenge to be overcome: The collective must be strong, to support loads, yet flow, to take new forms. We achieve this in a material-like robotic collective by modulating the interunit tangential forces to control topological rearrangements of units within a tigh...
• SCIENCE POLICY Mass firings decimate US science agencies AI翻译
  作者：Travis, John; Langin, Katie; Kaiser, Jocelyn; Wadman, Meredith
• Disease diagnostics using machine learning of B cell and T cell receptor sequences AI翻译
  作者：Zaslavsky, Maxim E.; Craig, Erin; Michuda, Jackson K.; Sehgal, Nidhi; Ram-Mohan, Nikhil; Lee, Ji-Yeun; Nguyen, Khoa D.; Hoh, Ramona A.; Pham, Tho D.; Roltgen, Katharina; Lam, Brandon; Parsons, Ella S.; Macwana, Susan R.; DeJager, Wade; Drapeau, Elizabeth M.; Roskin, Krishna M.; Cunningham-Rundles, Charlotte; Moody, M. Anthony; Haynes, Barton F.; Goldman, Jason D.; Heath, James R.; Chinthrajah, R. Sharon; Nadeau, Kari C.; Pinsky, Benjamin A.; Blish, Catherine A.; Hensley, Scott E.; Jensen, Kent; Meyer, Everett; Balboni, Imelda; Utz, Paul J.; Merrill, Joan T.; Guthridge, Joel M.; James, Judith A.; Yang, Samuel; Tibshirani, Robert; Kundaje, Anshul; Boyd, Scott D.
  作者单位：Stanford University; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford Medicine; Stanford University; Stanford University; University of Basel; Swiss Tropical & Public Health Institute; University of Basel; Stanford Medicine; Stanford University; Oklahoma Medical Research Foundation; University of Pennsylvania; Pennsylvania Medicine; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; Cincinnati Children's Hospital Medical Center; University of Cincinnati; Icahn School of Medicine at Mount Sinai; Duke University; Duke University; Duke University; Duke University; Swedish Health Services; University of Washington; University of Washington Seattle; Institute for Systems Biology (ISB); University of Washington; University of Washington Seattle; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; New York University; Stanford University
  摘要：Clinical diagnosis typically incorporates physical examination, patient history, various laboratory tests, and imaging studies but makes limited use of the human immune system's own record of antigen exposures encoded by receptors on B cells and T cells. We analyzed immune receptor datasets from 593 individuals to develop MAchine Learning for Immunological Diagnosis, an interpretive framework to screen for multiple illnesses simultaneously or precisely test for one condition. This approach det...
• Sleuth endows integrity grants AI翻译
  作者：Brainard, Jeffrey
• Nickel promotes selective ethylene epoxidation on silver AI翻译
  作者：Jalil, Anika; Happel, Elizabeth E.; Cramer, Laura; Hunt, Adrian; Hoffman, Adam S.; Waluyo, Iradwikanari; Montemore, Matthew M.; Christopher, Phillip; Sykes, E. Charles H.
  作者单位：University of California System; University of California Santa Barbara; Tufts University; United States Department of Energy (DOE); Brookhaven National Laboratory; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; United States Department of Energy (DOE); Stanford University; SLAC National Accelerator Laboratory; Tulane University; Tufts University
  摘要：Over the last 80 years, chlorine (Cl) has been the primary promoter of the ethylene epoxidation reaction valued at similar to 40 billion USD per year, providing a similar to 25% selectivity increase over unpromoted silver (Ag) (similar to 55%). Promoters such as cesium, rhenium, and molybdenum each add a few percent of selectivity enhancements to achieve 90% overall, but their codependence on Cl makes optimizing and understanding their function complex. We took a theory-guided, single-atom all...
• A direct hit AI翻译
  作者：Thorp, H. Holden
• Threats to peatlands mapped AI翻译
  作者：Brainard, Jeffrey
• Hidden cascades of seismic ice stream deformation AI翻译
  作者：Fichtner, Andreas; Hofstede, Coen; Kennett, Brian L. N.; Svensson, Anders; Westhoff, Julien; Walter, Fabian; Ampuero, Jean-Paul; Cook, Eliza; Zigone, Dimitri; Jansen, Daniela; Eisen, Olaf
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Australian National University; University of Copenhagen; Niels Bohr Institute; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute for Forest, Snow & Landscape Research; Swiss Federal Institutes of Technology Domain; ETH Zurich; Universite Cote d'Azur; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Observatoire de la Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; University of Bremen
  摘要：Ice streams are major regulators of sea level change. However, standard viscous flow simulations of their evolution have limited predictive power owing to incomplete understanding of involved processes. On the Greenland ice sheet, borehole fiber-optic observations revealed a brittle deformation mode that is incompatible with viscous flow, over length scales similar to the resolution of modern ice sheet models: englacial ice quake cascades that are unobservable at the surface. Nucleating near v...