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作者：Jalil, Anika; Happel, Elizabeth E.; Cramer, Laura; Hunt, Adrian; Hoffman, Adam S.; Waluyo, Iradwikanari; Montemore, Matthew M.; Christopher, Phillip; Sykes, E. Charles H.
作者单位：University of California System; University of California Santa Barbara; Tufts University; United States Department of Energy (DOE); Brookhaven National Laboratory; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Tulane University; Tufts University
摘要：Over the last 80 years, chlorine (Cl) has been the primary promoter of the ethylene epoxidation reaction valued at similar to 40 billion USD per year, providing a similar to 25% selectivity increase over unpromoted silver (Ag) (similar to 55%). Promoters such as cesium, rhenium, and molybdenum each add a few percent of selectivity enhancements to achieve 90% overall, but their codependence on Cl makes optimizing and understanding their function complex. We took a theory-guided, single-atom all...
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作者：Thorp, H. Holden
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作者：Barnett, Michael; Meister, Lena; Rainey, Paul B.
作者单位：Max Planck Society; Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Centre National de la Recherche Scientifique (CNRS)
摘要：Evolvability-the capacity to generate adaptive variation-is a trait that can itself evolve through natural selection. However, the idea that mutation can become biased toward adaptive outcomes remains controversial. In this work, we report the evolution of enhanced evolvability through localized hypermutation in experimental populations of bacteria. The evolved mechanism is analogous to the mutation-prone sequences of contingency loci observed in pathogenic bacteria. Central to this outcome wa...
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作者：Wu, Kai-Min; Xu, Qian-Hui; Liu, Yi-Qi; Feng, Yi-Wei; Han, Si-Da; Zhang, Ya-Ru; Chen, Shi-Dong; Guo, Yu; Wu, Bang-Sheng; Ma, Ling-Zhi; Zhang, Yi; Chen, Yi-Lin; Yang, Liu; Yang, Zhao-Fei; Xiao, Yu-Jie; Wang, Ting-Ting; Zhao, Jue; Chen, Shu-Fen; Cui, Mei; Lu, Bo-Xun; Le, Wei-Dong; Shu, You-Sheng; Ye, Keqiang; Li, Jia-Yi; Li, Wen-Sheng; Wang, Jian; Liu, Cong; Yuan, Peng; Yu, Jin-Tai
作者单位：Fudan University; Fudan University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Qingdao University; Qingdao Municipal Hospital; Dalian Medical University; Fudan University; Fudan University; Fudan University; Fudan University; University of Electronic Science & Technology of China; Sichuan Provincial People's Hospital; Emory University; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Lund University; China Medical University; Fudan University; Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; University of Chinese Academy of Sciences, CAS; Fudan University; Fudan University
摘要：Neuronal accumulation and spread of pathological alpha-synuclein (alpha-syn) fibrils are key events in Parkinson's disease (PD) pathophysiology. However, the neuronal mechanisms underlying the uptake of alpha-syn fibrils remain unclear. In this work, we identified FAM171A2 as a PD risk gene that affects alpha-syn aggregation. Overexpressing FAM171A2 promotes alpha-syn fibril endocytosis and exacerbates the spread and neurotoxicity of alpha-syn pathology. Neuronal-specific knockdown of FAM171A2...
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作者：[Anonymous]
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作者：Kussell, Edo
作者单位：New York University; New York University
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作者：Li, Yutao; Li, Zhaoxing; Yan, Purui; Hua, Chenyang; Kong, Jianping; Wu, Wanqian; Cui, Yurong; Duan, Yan; Li, Shunxiang; Li, Guanglei; Ji, Shunli; Chen, Yijun; Zhao, Yucheng; Yang, Peng; Hu, Chunyi; Lu, Meiling; Chen, Meirong; Xiao, Yibei
作者单位：China Pharmaceutical University; China Pharmaceutical University; China Pharmaceutical University; China Pharmaceutical University; Hunan University of Chinese Medicine; Nanjing University of Finance & Economics; China Pharmaceutical University; National University of Singapore; National University of Singapore
摘要：Prokaryotes have evolved diverse defense strategies against viral infection, including foreign nucleic acid degradation by CRISPR-Cas systems and DNA and RNA synthesis inhibition through nucleotide pool depletion. Here, we report an antiviral mechanism of type III CRISPR-Cas-regulated adenosine triphosphate (ATP) depletion in which ATP is converted into inosine triphosphate (ITP) by CRISPR-Cas-associated adenosine deaminase (CAAD) upon activation by either cA(4) or cA(6), followed by hydrolysi...
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作者：Sun, Qiu; Belting, Jan-Niklas; Hauda, Julian; Tymann, David; Antoni, Patrick W.; Goddard, Richard; Hansmann, Max M.
作者单位：Dortmund University of Technology; Max Planck Society
摘要：The introduction of a single C-atom into organic substrates typically results in the formation of flat molecules containing unsaturated C(sp)-centers. Adding a single C(sp(3))-atom surrounded by four sigma-C-C bonds, which opens up the three-dimensional space, is an unresolved problem in synthetic chemistry. We report the synthesis and application of the diazosulfur ylide Ph2S=C=N-2 reagent that combines the reactivity of both sulfur ylides and diazo compounds to create carbon spiro-centers in...
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作者：Brainard, Jeffrey
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作者：Xu, Shengduo; Horta, Sharona; Lawal, Abayomi; Maji, Krishnendu; Lorion, Magali; Ibanez, Maria
作者单位：Institute of Science & Technology - Austria
摘要：Thermoelectric coolers (TECs) are pivotal in modern heat management but face limitations in efficiency and manufacturing scalability. We address these challenges by using an extrusion-based 3D printing technique to fabricate high-performance thermoelectric materials. Our ink formulations ensure the integrity of the 3D-printed structure and effective particle bonding during sintering, achieving record-high figure of merit (zT) values of 1.42 for p-type bismuth antimony telluride [(Bi,Sb)(2)Te-3...
