作者：Hayes, Thomas; Rao, Roshan; Akin, Halil; Sofroniew, Nicholas J.; Oktay, Deniz; Lin, Zeming; Verkuil, Robert; Tran, Vincent Q.; Deaton, Jonathan; Wiggert, Marius; Badkundri, Rohil; Shafkat, Irhum; Gong, Jun; Derry, Alexander; Molina, Raul S.; Thomas, Neil; Khan, Yousuf A.; Mishra, Chetan; Kim, Carolyn; Bartie, Liam J.; Nemeth, Matthew; Hsu, Patrick D.; Sercu, Tom; Candido, Salvatore; Rives, Alexander
作者单位：University of California System; University of California Berkeley
摘要：More than 3 billion years of evolution have produced an image of biology encoded into the space of natural proteins. Here, we show that language models trained at scale on evolutionary data can generate functional proteins that are far away from known proteins. We present ESM3, a frontier multimodal generative language model that reasons over the sequence, structure, and function of proteins. ESM3 can follow complex prompts combining its modalities and is highly responsive to alignment to impr...
作者：Perren, Lara; Yarema, Maksym
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
作者：Wang, Hyun Suk; Agrachev, Mikhail; Kim, Hongsik; Truong, Nghia P.; Choi, Tae-Lim; Jeschke, Gunnar; Anastasaki, Athina
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：The reversion of vinyl polymers with carbon-carbon backbones to their monomers represents an ideal path to alleviate the growing plastic waste stream. However, depolymerizing such stable materials remains a challenge, with state-of-the-art methods relying on designer polymers that are neither commercially produced nor suitable for real-world applications. In this work, we report a main chain-initiated, visible light-triggered depolymerization directly applicable to commercial polymers containi...
作者：Chow, Jerry M.
作者单位：International Business Machines (IBM); IBM USA
作者：Gainty, Caitjan
作者单位：University of London; King's College London
