作者：Bender, S. Franz; van der Heijden, Marcel G. A.
作者单位：Swiss Federal Research Station Agroscope; University of Zurich
作者：Service, Robert F.
摘要：Minerals from volcanic rock could have supplied a key ingredient for biomolecules
作者：Lents, Nathan H.
作者单位：City University of New York (CUNY) System
作者：Ding, Kaixin; Zhang, Zhipeng; Han, Zhengbin; Shi, Lei; Li, Xinzhi; Liu, Yutong; Li, Zhenzhi; Zhao, Chongchong; Cui, Yifeng; Zhou, Liying; Xu, Bolin; Zhou, Wenjing; Zhao, Yikui; Wang, Zhiqiang; Huang, He; Xie, Liwei; Chen, Xiao-wei; Chen, Zheng
作者单位：Harbin Institute of Technology; Jilin University; Harbin Medical University; Fudan University; Peking University; Peking University; Guangdong Academy of Sciences
摘要：Maintaining glucose and lipid homeostasis is crucial for health, with dysregulation leading to metabolic diseases such as type 2 diabetes mellitus (T2DM) and metabolic dysfunction-associated fatty liver disease (MAFLD). This study identifies alkylation repair homolog protein 5 (ALKBH5), an RNA N6-methyladenosine (m6A) demethylase, as a major regulator in metabolic disease. ALKBH5 is up-regulated in the liver during obesity and also phosphorylated by protein kinase A, causing its translocation ...
作者：Zhang, Xiaochen; Li, Dong; Yang, Xuxu; Wang, Lei; Li, Guo; Wong, Tuck-Whye; Li, Tiefeng; Yang, Wei; Luo, Zisheng
作者单位：Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University
摘要：Hydrogels consist of cross-linked polymers that are highly swollen with water. Water evaporation or freezing during temperature changes may lead to stiff and brittle hydrogels. We introduce a strategy called hydro-locking, which involves immobilizing the water molecules within the polymer network of the hydrogel. This is accomplished by establishing robust connections between water molecules and the polymer by using sulfuric acid. A sacrificial network is introduced to shield the prime polymer...
