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作者：Wallis, Natalie J.; Mcclellan, Alyce; Morseburg, Alexander; Kentistou, Katherine A.; Jamaluddin, Aqfan; Dowsett, Georgina K. C.; Schofield, Ellen; Morros-Nuevo, Anna; Saeed, Sadia; Lam, Brian Y. H.; Sumanasekera, Natasha T.; Chan, Justine; Kumar, Sambhavi S.; Zhang, Rey M.; Wainwright, Jodie F.; Dittmann, Marie; Lakatos, Gabriella; Rainbow, Kara; Withers, David; Bounds, Rebecca; Ma, Marcella; German, Alexander J.; Ladlow, Jane; Sargan, David; Froguel, Philippe; Farooqi, I. Sadaf; Ong, Ken K.; Yeo, Giles S. H.; Tadross, John A.; Perry, John R. B.; Gorvin, Caroline M.; Raffan, Eleanor
作者单位：University of Cambridge; University of Cambridge; University of Cambridge; University of Cambridge; University of Birmingham; University of Birmingham; University of Nottingham; University of Cambridge; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Universite de Lille; Pasteur Network; Institut Pasteur Lille; Universite de Lille; CHU Lille; Imperial College London; University of Liverpool; University of Liverpool; University of Cambridge; University of Cambridge
摘要：Obesity is a heritable disease, but its genetic basis is incompletely understood. Canine population history facilitates trait mapping. We performed a canine genome-wide association study for body condition score-a measure of obesity-in 241 Labrador retrievers. Using a cross-species approach, we showed that canine obesity genes are also associated with rare and common forms of obesity in humans. The lead canine association was within the gene DENN domain containing 1B (DENND1B). Each copy of th...
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作者：Cohen, Jon; Reardon, Sara
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作者：Ha, Kyoung-Ho; Yoo, Jaeyoung; Li, Shupeng; Mao, Yuxuan; Xu, Shengwei; Qi, Hongyuan; Wu, Hanbing; Fan, Chengye; Yuan, Hanyin; Kim, Jin-Tae; Flavin, Matthew T.; Yoo, Seonggwang; Shahir, Pratyush; Kim, Sangjun; Ahn, Hak-Young; Colgate, Edward; Huang, Yonggang; Rogers, John A.
作者单位：Northwestern University; Sungkyunkwan University (SKKU); Northwestern University; Shanghai Jiao Tong University; Pohang University of Science & Technology (POSTECH); University System of Georgia; Georgia Institute of Technology; Inje University; Northwestern University; University of Texas System; University of Texas Austin; Northwestern University; Northwestern University; Northwestern University; Feinberg School of Medicine
摘要：The sense of touch conveys critical environmental information, facilitating object recognition, manipulation, and social interaction, and can be engineered through haptic actuators that stimulate cutaneous receptors. An unfulfilled challenge lies in haptic interface technologies that can engage all the various mechanoreceptors in a programmable, spatiotemporal fashion across large areas of the body. Here, we introduce a small-scale actuator technology that can impart omnidirectional, superimpo...
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作者：Hsieh, Shan-Chi; Fulop, Mate; Schargel, Richard; Petassi, Michael T.; Barabas, Orsolya; Peters, Joseph E.
作者单位：Cornell University; University of Geneva
摘要：Eukaryotes have linear DNA, and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. We identified several families of independently evolved telomeric transposons in linear chromosomes and plasmids of cyanobacteria and Streptomyces. Although these elements have one specific transposon end sequence, with the second boundary being the telomere, we can show that they move using two transposon ends, likely when transiently bridged by the telomere mainte...
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作者：Jain, Aakriti; Heremans, Isaac; Rademaker, Gilles; Detomasi, Tyler C.; Rohweder, Peter; Anderson, Dashiell; Zhang, Justin; Hernandez, Grace A.; Gupta, Suprit; von Linde, Teresa; Lange, Mike; Spacci, Martina; Luo, Jiayi; Citron, Y. Rose; Olzmann, James A.; Dawson, David W.; Craik, Charles S.; Bommer, Guido; Perera, Rushika M.; Zoncu, Roberto
作者单位：University of California System; University of California Berkeley; Universite Catholique Louvain; Universite Catholique Louvain; WELBIO; University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco; University of California System; University of California Berkeley; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; UCLA Jonsson Comprehensive Cancer Center; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：Breakdown of every transmembrane protein trafficked to lysosomes requires proteolysis of their hydrophobic helical transmembrane domains. Combining lysosomal proteomics with functional genomic datasets, we identified lysosomal leucine aminopeptidase (LyLAP; formerly phospholipase B domain-containing 1) as the hydrolase most tightly associated with elevated endocytosis. Untargeted metabolomics and biochemical reconstitution demonstrated that LyLAP is a processive monoaminopeptidase with prefere...
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作者：Tate IV, William F.
作者单位：Louisiana State University System; Louisiana State University
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作者：Ockendon-Powell, Nina
作者单位：University of Bristol
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作者：Gautam, Arya; Ghimire, Sandesh; Jha, Aashish R.
作者单位：New York University; New York University Abu Dhabi; New York University; New York University Abu Dhabi; New York University; New York University Abu Dhabi
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作者：Li, Mengyao; Jiang, Zhenhuan; Xu, Xueqiang; Wu, Xinglong; Liu, Yun; Chen, Kexuan; Liao, Yuhan; Li, Wen; Wang, Xiao; Guo, Yuqing; Zhang, Bo; Wen, Lu; Kee, Kehkooi; Tang, Fuchou
作者单位：Peking University; Changping Laboratory; National Institute of Biological Sciences, Beijing; Peking University; Tsinghua University; Tsinghua University; Hebei Agricultural University; Shanxi Medical University
摘要：In mammals, fertilized eggs undergo genome-wide epigenetic reprogramming to generate the organism. However, our understanding of epigenetic dynamics during preimplantation development at single-cell resolution remains incomplete. Here, we developed scNanoATAC-seq2, a single-cell assay for transposase-accessible chromatin using long-read sequencing for scarce samples. We present a detailed chromatin accessibility landscape of mouse preimplantation development, revealing distinct chromatin signa...
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作者：Robles-Gil, Alexa
