6744期

最新文章

• BIOMEDICINE Companies seek second GLP-1 revolution-in pill form AI翻译
  作者：Brazil, Rachel
• Deep-tissue transcriptomics and subcellular imaging at high spatial resolution AI翻译
  作者：Gandin, Valentina; Kim, Jun; Yang, Liang-Zhong; Lian, Yumin; Kawase, Takashi; Hu, Amy; Rokicki, Konrad; Fleishman, Greg; Tillberg, Paul; Castrejon, Alejandro Aguilera; Stringer, Carsen; Preibisch, Stephan; Liu, Zhe J.
  摘要：Limited color channels in fluorescence microscopy have long constrained spatial analysis in biological specimens. We introduce cycle hybridization chain reaction (cycleHCR), a method that integrates multicycle DNA barcoding with HCR to overcome this limitation. cycleHCR enables highly multiplexed imaging of RNA and proteins using a unified barcode system. Whole-embryo transcriptomics imaging achieved precise three-dimensional gene expression and cell fate mapping across a specimen depth of sim...
• Risky moves AI翻译
  作者：Leslie, Mitch
• Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology AI翻译
  作者：Sanguankiattichai, Nattapong; Chandrasekar, Balakumaran; Sheng, Yuewen; Hardenbrook, Nathan; Tabak, Werner W. A.; Drapal, Margit; Kaschani, Farnusch; Gruenwald-Gruber, Clemens; Krahn, Daniel; Buscaill, Pierre; Yamamoto, Suzuka; Kato, Atsushi; Nash, Robert; Fleet, George; Strasser, Richard; Fraser, Paul D.; Kaiser, Markus; Zhang, Peijun; Preston, Gail M.; van der Hoorn, Renier A. L.
  作者单位：University of Oxford; Mahidol University; Diamond Light Source; University of Oxford; Wellcome Centre for Human Genetics; University of Duisburg Essen; University of London; Royal Holloway University London; University of Duisburg Essen; BOKU University; Dortmund University of Technology; Leibniz Association; Leibniz Institut fur Analytische Wissenschaften (ISAS); University of Toyama; University of Oxford; BOKU University
  摘要：The extracellular space (apoplast) in plants is a key battleground during microbial infections. To avoid recognition, the bacterial model phytopathogen Pseudomonas syringae pv. tomato DC3000 produces glycosyrin. Glycosyrin inhibits the plant-secreted beta-galactosidase BGAL1, which would otherwise initiate the release of immunogenic peptides from bacterial flagellin. Here, we report the structure, biosynthesis, and multifunctional roles of glycosyrin. High-resolution cryo-electron microscopy a...
• ENERGY RESEARCH Lawsuit challenges DOE indirect costs cut AI翻译
  作者：Mervis, Jeffrey
• Developing countries locked out of low-carbon technology trade AI翻译
  作者：Bandara, Praveena; Ray, Rebecca; Lu, Jiaqi; Gallagher, Kevin P.
  作者单位：Boston University
• When state support for science fails AI翻译
  作者：Lazcano, Antonio
  作者单位：Universidad Nacional Autonoma de Mexico
• Overcoming roadblocks to a global plastic pact AI翻译
  作者：Shah, Farooq; Wu, Wei
  作者单位：Hainan University; Abdul Wali Khan University
• Perfect Coulomb drag and exciton transport in an excitonic insulator AI翻译
  作者：Qi, Ruishi; Joe, Andrew Y.; Zhang, Zuocheng; Xie, Jingxu; Feng, Qixin; Lu, Zheyu; Wang, Ziyu; Taniguchi, Takashi; Watanabe, Kenji; Tongay, Sefaattin; Wang, Feng
  作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; University of California System; University of California Berkeley; Xi'an Jiaotong University; National Institute for Materials Science; National Institute for Materials Science; Arizona State University; Arizona State University-Tempe; University of California System; University of California Berkeley
  摘要：Strongly coupled electron-hole bilayers can host quantum states of interlayer excitons, such as high-temperature exciton condensates at zero magnetic field. This state is predicted to feature perfect Coulomb drag, where a current in one layer is accompanied by an equal but opposite current in the other. We used an optical technique to probe the electrical transport of correlated electron-hole bilayers based on MoSe2/hBN/WSe2 heterostructures. We observed perfect Coulomb drag in the excitonic i...
• TRUMP ADMINISTRATION NIH bars Chinese scientists, others from databases AI翻译
  作者：Stone, Richard