6744期

最新文章

• Structural basis for nucleolin recognition of MYC promoter G-quadruplex AI翻译
  作者：Chen, Luying; Dickerhoff, Jonathan; Zheng, Ke-wei; Erramilli, Satchal; Feng, Hanqiao; Wu, Guanhui; Onel, Buket; Chen, Yuwei; Wang, Kai-Bo; Carver, Megan; Lin, Clement; Sakai, Saburo; Wan, Jun; Vinson, Charles; Hurley, Laurence; Kossiakoff, Anthony A.; Deng, Nanjie; Bai, Yawen; Noinaj, Nicholas; Yang, Danzhou
  作者单位：Purdue University System; Purdue University; Hunan University; University of Chicago; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University of Arizona; Indiana University System; Indiana University Bloomington; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Pace University; Purdue University System; Purdue University; Purdue University System; Purdue University; Purdue University System; Purdue University
  摘要：The MYC oncogene promoter G-quadruplex (MycG4) regulates transcription and is a prevalent G4 locus in immortal cells. Nucleolin, a major MycG4-binding protein, exhibits greater affinity for MycG4 than for nucleolin recognition element (NRE) RNA. Nucleolin's four RNA binding domains (RBDs) are essential for high-affinity MycG4 binding. We present the 2.6-angstrom crystal structure of the nucleolin-MycG4 complex, revealing a folded parallel three-tetrad G-quadruplex with two coordinating potassi...
• Global soil pollution by toxic metals threatens agriculture and human health AI翻译
  作者：Hou, Deyi; Jia, Xiyue; Wang, Liuwei; McGrath, Steve P.; Zhu, Yong-Guan; Hu, Qing; Zhao, Fang-Jie; Bank, Michael S.; O'Connor, David; Nriagu, Jerome
  作者单位：Tsinghua University; Tsinghua University; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); Rothamsted Research; Chinese Academy of Sciences; Research Center for Eco-Environmental Sciences (RCEES), CAS; Chinese Academy of Sciences; Institute of Urban Environment, CAS; Southern University of Science & Technology; Nanjing Agricultural University; Institute of Marine Research - Norway; University of Massachusetts System; University of Massachusetts Amherst; Royal Agricultural University; University of Michigan System; University of Michigan
  摘要：Toxic metal pollution is ubiquitous in soils, yet its worldwide distribution is unknown. We analyzed a global database of soil pollution by arsenic, cadmium, cobalt, chromium, copper, nickel, and lead at 796,084 sampling points from 1493 regional studies and used machine learning techniques to map areas with exceedance of agricultural and human health thresholds. We reveal a previously unrecognized high-risk, metal-enriched zone in low-latitude Eurasia, which is attributed to influential clima...
• Off the Spectrum: Why the Science of Autism Has Failed Women and Girls AI翻译
  作者：Lai, Meng-Chuan
• Prevent coastal seawater intrusion in China AI翻译
  作者：Liu, Chao; Li, Ping; Liu, Dahai
  作者单位：Ministry of Natural Resources of the People's Republic of China; First Institute of Oceanography, Ministry of Natural Resources; Ocean University of China; Renmin University of China
• HIGHER EDUCATION After grant cuts, universities offer faculty a lifeline AI翻译
  作者：Mervis, Jeffrey
• How bacteria subvert plant immunity AI翻译
  作者：Schroeder, Frank C.
  作者单位：Cornell University; Boyce Thompson Institute for Plant Research; Cornell University
• Pig kidney transplant fails AI翻译
  作者：Chakradhar, Shraddha
• Not a 'DEI hire' AI翻译
  作者：Dildine, Troy Christopher
  作者单位：Stanford University
• The genetic architecture of cell type-specific cis regulation in maize AI翻译
  作者：Marand, Alexandre P.; Jiang, Luguang; Gomez-Cano, Fabio; Minow, Mark A. A.; Zhang, Xuan; Mendieta, John P.; Luo, Ziliang; Bang, Sohyun; Yan, Haidong; Meyer, Cullan; Schlegel, Luca; Johannes, Frank; Schmitz, Robert J.
  作者单位：University System of Georgia; University of Georgia; University of Michigan System; University of Michigan; University System of Georgia; University of Georgia; Technical University of Munich
  摘要：Gene expression and complex phenotypes are determined by the activity of cis-regulatory elements. However, an understanding of how extant genetic variants affect cis regulation remains limited. Here, we investigated the consequences of cis-regulatory diversity using single-cell genomics of more than 0.7 million nuclei across 172 Zea mays (maize) inbreds. Our analyses pinpointed cis-regulatory elements distinct to domesticated maize and revealed how historical transposon activity has shaped the...
• Carbonates identified by the Curiosity rover indicate a carbon cycle operated on ancient Mars AI翻译
  作者：Tutolo, Benjamin M.; Hausrath, Elisabeth M.; Kite, Edwin S.; Rampe, Elizabeth B.; Bristow, Thomas F.; Downs, Robert T.; Treiman, Allan; Peretyazhko, Tanya S.; Thorpe, Michael T.; Grotzinger, John P.; Roberts, Amelie L.; Archer, P. Douglas; Des Marais, David J.; Blake, David F.; Vaniman, David T.; Morrison, Shaunna M.; Chipera, Steve; Hazen, Robert M.; Morris, Richard V.; Tu, Valerie M.; Simpson, Sarah L.; Pandey, Aditi; Yen, Albert; Larter, Stephen R.; Craig, Patricia; Castle, Nicholas; Ming, Douglas W.; Meusburger, Johannes M.; Fraeman, Abigail A.; Burtt, David G.; Franz, Heather B.; Sutter, Brad; Clark, Joanna V.; Rapin, William; Bridges, John C.; Loche, Matteo; Gasda, Patrick; Frydenvang, Jens; Vasavada, Ashwin R.
  作者单位：University of Calgary; Nevada System of Higher Education (NSHE); University of Nevada Las Vegas; University of Chicago; National Aeronautics & Space Administration (NASA); NASA Johnson Space Center; National Aeronautics & Space Administration (NASA); NASA Ames Research Center; University of Arizona; Universities Space Research Association (USRA); National Aeronautics & Space Administration (NASA); NASA Johnson Space Center; University System of Maryland; University of Maryland College Park; National Aeronautics & Space Administration (NASA); NASA Goddard Space Flight Center; California Institute of Technology; Imperial College London; Carnegie Institution for Science; Rutgers University System; Rutgers University New Brunswick; Texas State University System; Texas State University San Marcos; National Aeronautics & Space Administration (NASA); NASA Johnson Space Center; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); Universite de Toulouse; Universite Toulouse III - Paul Sabatier; Centre National de la Recherche Scientifique (CNRS); University of Leicester; United States Department of Energy (DOE); Los Alamos National Laboratory; University of Copenhagen
  摘要：Ancient Mars had surface liquid water and a dense carbon dioxide (CO2)-rich atmosphere. Such an atmosphere would interact with crustal rocks, potentially leaving a mineralogical record of its presence. We analyzed the composition of an 89-meter stratigraphic section of Gale crater, Mars, using data collected by the Curiosity rover. An iron carbonate mineral, siderite, occurs in abundances of 4.8 to 10.5 weight %, colocated with highly water-soluble salts. We infer that the siderite formed in w...