6746期

最新文章

• Interphase cell morphology defines the mode, symmetry, and outcome of mitosis AI翻译
  作者：Lovegrove, Holly E.; Hulmes, Georgia E.; Ghadaouia, Sabrina; Revell, Christopher; Giralt-Pujol, Marta; Alhashem, Zain; Pena, Andreia; Nogare, Damian D.; Appleton, Ellen; Costa, Guilherme; Mort, Richard L.; Ballestrem, Christoph; Jones, Gareth W.; Manning, Cerys S.; Chitnis, Ajay B.; Franco, Claudio A.; Linker, Claudia; Bentley, Katie; Herbert, Shane P.
  作者单位：University of Manchester; Yale University; Francis Crick Institute; University of Manchester; Boston University; Boston University; University of Leeds; University of London; King's College London; Universidade de Lisboa; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD); Human Technopole; Queens University Belfast; Lancaster University; Universidade Catolica Portuguesa; University of London; King's College London; University of Leeds
  摘要：During tissue formation, dynamic cell shape changes drive morphogenesis while asymmetric divisions create cellular diversity. We found that the shifts in cell morphology that shape tissues could concomitantly act as conserved instructive cues that trigger asymmetric division and direct core identity decisions underpinning tissue building. We performed single-cell morphometric analyses of endothelial and other mesenchymal-like cells. Distinct morphological changes switched cells to an isomorphi...
• Tariff war takes toll on labs in China AI翻译
  作者：Stone, Richard
• China's pet squirrel trade needs regulation AI翻译
  作者：Yang, Yueqin; Xiang, Jishan; Yi, Xianfeng
  作者单位：Henan University of Science & Technology; Yili Normal University
• Intracellular protein editing enables incorporation of noncanonical residues in endogenous proteins AI翻译
  作者：Beyer, Jenna N.; Serebrenik, Yevgeniy V.; Toy, Kaitlyn; Najar, Mohd. Altaf; Feierman, Emily; Raniszewski, Nicole R.; Korb, Erica; Shalem, Ophir; Burslem, George M.
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania
  摘要：The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split intein-mediated protein splicing, genetic code expansion, and endogenous protein tagging. This approach enables us to rapidly and site-specifically install residues and chemical handles into a protein. We demonstrate the power of this platform to edit cellular proteins, inserting epitopes, protein-s...
• Cryo-EM reveals mechanisms of natural RNA multivalency AI翻译
  作者：Wang, Liu; Xie, Jiahao; Gong, Tao; Wu, Hao; Tu, Yifan; Peng, Xin; Shang, Sitong; Jia, Xinyu; Ma, Haiyun; Zou, Jian; Xu, Sheng; Zheng, Xin; Zhang, Dong; Liu, Yang; Zhang, Chong; Luo, Yongbo; Huang, Zirui; Shao, Bin; Ying, Binwu; Cheng, Yu; Guo, Yingqiang; Lai, Ying; Huang, Dingming; Liu, Jianquan; Wei, Yuquan; Sun, Siqi; Zhou, Xuedong; Su, Zhaoming
  作者单位：Sichuan University; Sichuan University; Sichuan University; Fudan University; Sichuan University; Sichuan University; Chinese University of Hong Kong; Sichuan University
  摘要：Homo-oligomerization of biological macromolecules leads to functional assemblies that are critical to understanding various cellular processes. However, RNA quaternary structures have rarely been reported. Comparative genomics analysis has identified RNA families containing hundreds of sequences that adopt conserved secondary structures and likely fold into complex three-dimensional structures. In this study, we used cryo-electron microscopy (cryo-EM) to determine structures from four RNA fami...
• An uphill grind for wild plant populations AI翻译
  作者：Aitken, Sally N.
  作者单位：University of British Columbia
• A fungal ally wards off liver disease AI翻译
  作者：Hooper, Lora V.; Koh, Andrew Y.
  作者单位：University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center
• Discovery research in physiologically maintained deceased AI翻译
  作者：Pet, Douglas B.; Parent, Brendan; Singhal, Neel S.; Clelland, Claire D.
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
• Ecologist blurred professional boundaries, report finds AI翻译
  作者：O'Grady, Cathleen
• Geometrically frustrated rose petals AI翻译
  作者：Zhang, Yafei; Cohen, Omri Y.; Moshe, Michael; Sharon, Eran
  作者单位：Hebrew University of Jerusalem
  摘要：Growth and form are deeply interconnected, in a manner often mediated by mechanical instabilities arising from geometric incompatibilities. Although Gauss incompatibility has long been recognized as the source of morphing in naturally growing slender organs, here we show that the growth profile of rose petals remains Gauss compatible. Their distinctive shape emerges from a different type of geometric incompatibility, the Mainardi-Codazzi-Peterson (MCP) incompatibility, which leads to the forma...