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作者:Zhu, Xin; Bennett, Timothy J. D.; Zouboulis, Konstantin C.; Soulias, Dimitrios; Grzybek, Michal; Benesch, Justin L. P.; El-Sagheer, Afaf H.; Coskun, Uenal; Krishnan, Madhavi
作者单位:University of Oxford; University of Oxford; Technische Universitat Dresden; Carl Gustav Carus University Hospital; Technische Universitat Dresden; University of Southampton; University of Southampton; Technische Universitat Dresden; Carl Gustav Carus University Hospital; German Center for Diabetes Research (DZD); Max Planck Society
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作者:Bai, Xuemei; Shi, Peijun
作者单位:Australian National University; Beijing Normal University
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作者:Cohen, Jon; Wadman, Meredith
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作者:Dolgin, Elie
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作者:Yang, Jie; Li, Wei; Chen, Ai-lin; Du, Kun-sheng; Peng, Xiao; Wang, Yu; Zhang, Xi-guang; Smith, Martin R.
作者单位:Yunnan University; Yuxi Normal University; Yunnan University; Durham University
摘要:The Cambrian evolutionary radiation is noted for its profusion of bizarre and unfamiliar body forms, many of which illuminate the early ancestry of major animal groups. The spine-covered fossil Shishania aculeata (Cambrian Stage 4, Yunnan, China) has been interpreted as intermediate between mollusks and their lophotrochozoan ancestors. Our new material challenges this interpretation. We propose taphonomic explanations for apparent molluscan features and instead identify prominent anatomical si...
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作者:Borgonovi, Francesca; Pokropek, Artur
作者单位:University of London; University College London; Organisation for Economic Co-operation & Development (OECD); Educational Research Institute (IBE)
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作者:Ely, Zackery A.; Kulstad, Zachary J.; Gunaydin, Gurcan; Addepalli, Sudarsana; Verzani, Eva K.; Casarrubios, Marta; Clauser, Karl R.; Wang, Xilin; Lippincott, Isabelle E.; Louvet, Cedric; Schmitt, Thomas; Kapner, Kevin S.; Agus, Miles P.; Hennessey, Connor J.; Cleary, James M.; Hadrup, Sine R.; Klaeger, Susan; Su, Jennifer; Jaeger, Alex M.; Wolpin, Brian M.; Raghavan, Srivatsan; Smith, Eric L.; Greenberg, Philip D.; Aguirre, Andrew J.; Abelin, Jennifer G.; Carr, Steven A.; Jacks, Tyler; Freed-Pastor, William A.
作者单位:Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; Fred Hutchinson Cancer Center; Technical University of Denmark; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Columbia University; Roche Holding; Genentech; Roche Holding USA; H Lee Moffitt Cancer Center & Research Institute
摘要:Translation of the noncoding genome in cancer can generate cryptic (noncanonical) peptides capable of presentation by human leukocyte antigen class I (HLA-I); however, the cancer specificity and immunogenicity of noncanonical HLA-I-bound peptides (ncHLAp) are incompletely understood. Using high-resolution immunopeptidomics, we discovered that cryptic peptides are abundant in the pancreatic cancer immunopeptidome. Approximately 30% of ncHLAp exhibited cancer-restricted translation, and a substa...
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作者:Orrall, Avery
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作者:Mervis, Jeffrey