作者:Tollefson, Jeff
摘要:Allegations against Claudine Gay have left researchers arguing over academic standards and practices.
作者:Crow, James Mitchell; Sarpong, Richmond
作者单位:University of California System; University of California Berkeley
作者:Dunkelmann, Daniel L.; Piedrafita, Carlos; Dickson, Alexandre; Liu, Kim C.; Elliott, Thomas S.; Fiedler, Marc; Bellini, Dom; Zhou, Andrew; Cervettini, Daniele; Chin, Jason W.
作者单位:MRC Laboratory Molecular Biology; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
摘要:The genetic code of living cells has been reprogrammed to enable the site-specific incorporation of hundreds of non-canonical amino acids into proteins, and the encoded synthesis of non-canonical polymers and macrocyclic peptides and depsipeptides1-3. Current methods for engineering orthogonal aminoacyl-tRNA synthetases to acylate new monomers, as required for the expansion and reprogramming of the genetic code, rely on translational readouts and therefore require the monomers to be ribosomal ...