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作者：Aslett, Kevin; Sanderson, Zeve; Godel, William; Persily, Nathaniel; Nagler, Jonathan; Tucker, Joshua A.
作者单位：State University System of Florida; University of Central Florida; New York University; Stanford University; New York University
摘要：Considerable scholarly attention has been paid to understanding belief in online misinformation1,2, with a particular focus on social networks. However, the dominant role of search engines in the information environment remains underexplored, even though the use of online search to evaluate the veracity of information is a central component of media literacy interventions3-5. Although conventional wisdom suggests that searching online when evaluating misinformation would reduce belief in it, t...
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作者：Lenharo, Mariana
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作者：You, Xiaoying
摘要：The heat stored in the world's oceans increased by the greatest margin ever in 2023.
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作者：[Anonymous]
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作者：Cho, Min-Guk; Kumar, Rashmi J.; Lin, Chien-Chu; Boyer, Joshua A.; Shahir, Jamshaid A.; Fagan-Solis, Katerina; Simpson, Dennis A.; Fan, Cheng; Foster, Christine E.; Goddard, Anna M.; Lerner, Lynn M.; Ellington, Simon W.; Wang, Qinhong; Wang, Ying; Ho, Alice Y.; Liu, Pengda; Perou, Charles M.; Zhang, Qi; McGinty, Robert K.; Purvis, Jeremy E.; Gupta, Gaorav P.
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina; University of North Carolina Chapel Hill
摘要：Oncogene-induced replication stress generates endogenous DNA damage that activates cGAS-STING-mediated signalling and tumour suppression1-3. However, the precise mechanism of cGAS activation by endogenous DNA damage remains enigmatic, particularly given that high-affinity histone acidic patch (AP) binding constitutively inhibits cGAS by sterically hindering its activation by double-stranded DNA (dsDNA)4-10. Here we report that the DNA double-strand break sensor MRE11 suppresses mammary tumorig...
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作者：Sun, Yuxiang; Dai, Hui; Dai, Xiaoxia; Yin, Jiekai; Cui, Yuxiang; Liu, Xiaochuan; Gonzalez, Gwendolyn; Yuan, Jun; Tang, Feng; Wang, Nan; Perlegos, Alexandra E.; Bonini, Nancy M.; Yang, X. William; Gu, Weifeng; Wang, Yinsheng
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作者：Callaway, Ewen
摘要：An automated laboratory system spent half a year engineering enzymes to work at higher temperatures.
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作者：Fu, Wenyu; Vasylyev, Dmytro; Bi, Yufei; Zhang, Mingshuang; Sun, Guodong; Khleborodova, Asya; Huang, Guiwu; Zhao, Libo; Zhou, Renpeng; Li, Yonggang; Liu, Shujun; Cai, Xianyi; He, Wenjun; Cui, Min; Zhao, Xiangli; Hettinghouse, Aubryanna; Good, Julia; Kim, Ellen; Strauss, Eric; Leucht, Philipp; Schwarzkopf, Ran; Guo, Edward X.; Samuels, Jonathan; Hu, Wenhuo; Attur, Mukundan; Waxman, Stephen G.; Liu, Chuan-ju
作者单位：New York University; Yale University; Yale University; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Connecticut Healthcare System; Columbia University; New York University; Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; New York University
摘要：Osteoarthritis (OA) is the most common joint disease. Currently there are no effective methods that simultaneously prevent joint degeneration and reduce pain(1). Although limited evidence suggests the existence of voltage-gated sodium channels (VGSCs) in chondrocytes(2), their expression and function in chondrocytes and in OA remain essentially unknown. Here we identify Na(v)1.7 as an OA-associated VGSC and demonstrate that human OA chondrocytes express functional Na(v)1.7 channels, with a den...
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作者：Tamessar, Cottrell
作者单位：University of Newcastle; Hunter Medical Research Institute
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作者：[Anonymous]
