7995期

最新文章

• US particle physicists want to build a muon collider - Europe should pitch in AI翻译
  作者：[Anonymous]
  摘要：A feasibility study for a muon smasher in the United States could be an affordable way to maintain particle-physics unity.
• Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides AI翻译
  作者：Huang, Di; Zhu, Xiaofeng; Ye, Shuying; Zhang, Jiahui; Liao, Jianyou; Zhang, Ning; Zeng, Xin; Wang, Jiawen; Yang, Bing; Zhang, Yin; Lao, Liyan; Chen, Jianing; Xin, Min; Nie, Yan; Saw, Phei Er; Su, Shicheng; Song, Erwei
  作者单位：Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
  摘要：Emerging data have shown that previously defined noncoding genomes might encode peptides that bind human leukocyte antigen (HLA) as cryptic antigens to stimulate adaptive immunity1,2. However, the significance and mechanisms of action of cryptic antigens in anti-tumour immunity remain unclear. Here mass spectrometry of the HLA class I (HLA-I) peptidome coupled with ribosome sequencing of human breast cancer samples identified HLA-I-binding cryptic antigenic peptides that were noncanonically tr...
• A novel antibiotic class targeting the lipopolysaccharide transporter AI翻译
  作者：Zampaloni, Claudia; Mattei, Patrizio; Bleicher, Konrad; Winther, Lotte; Thate, Claudia; Bucher, Christian; Adam, Jean-Michel; Alanine, Alexander; Amrein, Kurt E.; Baidin, Vadim; Bieniossek, Christoph; Bissantz, Caterina; Boess, Franziska; Cantrill, Carina; Clairfeuille, Thomas; Dey, Fabian; Di Giorgio, Patrick; du Castel, Pauline; Dylus, David; Dzygiel, Pawel; Felici, Antonio; Garcia-Alcalde, Fernando; Haldimann, Andreas; Leipner, Matthew; Leyn, Semen; Louvel, Severine; Misson, Pauline; Osterman, Andrei; Pahil, Karanbir; Rigo, Sebastien; Schaublin, Adrian; Scharf, Sebastian; Schmitz, Petra; Stoll, Theodor; Trauner, Andrej; Zoffmann, Sannah; Kahne, Daniel; Young, John A. T.; Lobritz, Michael A.; Bradley, Kenneth A.
  作者单位：Roche Holding; Roche Holding; Roche Holding; Johnson & Johnson; Janssen Pharmaceuticals; Johson & Johnson Belgium; Harvard University; Sanford Burnham Prebys Medical Discovery Institute; Roche Holding; Johnson & Johnson; Johson & Johnson Belgium; Janssen Pharmaceuticals
  摘要：Carbapenem-resistant Acinetobacter baumannii (CRAB) has emerged as a major global pathogen with limited treatment options1. No new antibiotic chemical class with activity against A. baumannii has reached patients in over 50 years1. Here we report the identification and optimization of tethered macrocyclic peptide (MCP) antibiotics with potent antibacterial activity against CRAB. The mechanism of action of this molecule class involves blocking the transport of bacterial lipopolysaccharide from ...
• BCG: WHY PEOPLE'S IMMUNE RESPONSES TO VACCINE VARY AI翻译
  作者：[Anonymous]
• Ionized gas extends over 40 kpc in an odd radio circle host galaxy AI翻译
  作者：Coil, Alison L.; Perrotta, Serena; Rupke, David S. N.; Lochhaas, Cassandra; Tremonti, Christy A.; Diamond-Stanic, Aleks; Fielding, Drummond; Geach, James E.; Hickox, Ryan C.; Moustakas, John; Rudnick, Gregory H.; Sell, Paul; Whalen, Kelly E.
  作者单位：University of California System; University of California San Diego; Space Telescope Science Institute; University of Wisconsin System; University of Wisconsin Madison; Simons Foundation; Flatiron Institute; University of Hertfordshire; Dartmouth College; University of Kansas; State University System of Florida; University of Florida
  摘要：A new class of extragalactic astronomical sources discovered in 2021, named odd radio circles (ORCs)1, are large rings of faint, diffuse radio continuum emission spanning approximately 1 arcminute on the sky. Galaxies at the centres of several ORCs have photometric redshifts of z similar or equal to 0.3-0.6, implying physical scales of several 100 kpc in diameter for the radio emission, the origin of which is unknown. Here we report spectroscopic data on an ORC including strong [O ii] emission...
• Large language models help computer programs to evolve AI翻译
  作者：Mouret, Jean-Baptiste
  作者单位：Universite de Lorraine; Centre National de la Recherche Scientifique (CNRS)
  摘要：A branch of computer science known as genetic programming has been given a boost with the application of large language models that are trained on the combined intuition of the world's programmers.
• Why the immune response to a vaccine varies from person to person AI翻译
  作者：[Anonymous]
  摘要：A dormant immune system before receiving the BCG vaccine is tied to a greater innate immune response afterwards.
• Chimpanzees are dying from our colds - these scientists are trying to save them AI翻译
  作者：Nuwer, Rachel
  摘要：Humans are increasingly passing pathogens to animal populations, imperilling endangered species such as chimpanzees and gorillas.
• Self-assembling DNA recognizes patterns AI翻译
  作者：Phillips, Andrew
  摘要：Self-assembling DNA can process information, but the computations have been limited to digital algorithms. A self-assembling DNA system has now been designed to perform complex pattern recognition.
• 'BULLETPROOF' POLYMERS STIFFEN SQUISHY HYDROGEL AI翻译
  作者：[Anonymous]