作者：Baldwin, Eric T.; van Eeuwen, Trevor; Hoyos, David; Zalevsky, Arthur; Tchesnokov, Egor P.; Sanchez, Roberto; Miller, Bryant D.; Di Stefano, Luciano H.; Ruiz, Francesc Xavier; Hancock, Matthew; Isik, Esin; Mendez-Dorantes, Carlos; Walpole, Thomas; Nichols, Charles; Wan, Paul; Riento, Kirsi; Halls-Kass, Rowan; Augustin, Martin; Lammens, Alfred; Jestel, Anja; Upla, Paula; Xibinaku, Kera; Congreve, Samantha; Hennink, Maximiliaan; Rogala, Kacper B.; Schneider, Anna M.; Fairman, Jennifer E.; Christensen, Shawn M.; Desrosiers, Brian; Bisacchi, Gregory S.; Saunders, Oliver L.; Hafeez, Nafeeza; Miao, Wenyan; Kapeller, Rosana; Zaller, Dennis M.; Sali, Andrej; Weichenrieder, Oliver; Burns, Kathleen H.; Goette, Matthias; Rout, Michael P.; Arnold, Eddy; Greenbaum, Benjamin D.; Romero, Donna L.; Lacava, John; Taylor, Martin S.
作者单位：Rockefeller University; Memorial Sloan Kettering Cancer Center; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of Alberta; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; University of Groningen; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Massachusetts Institute of Technology (MIT); Whitehead Institute; Stanford University; Stanford University; Stanford Cancer Institute; Stanford University; Max Planck Society; Johns Hopkins University; University of Texas System; University of Texas Arlington; Cornell University; Weill Cornell Medicine; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital
摘要：The LINE-1 (L1) retrotransposon is an ancient genetic parasite that has written around one-third of the human genome through a 'copy and paste' mechanism catalysed by its multifunctional enzyme, open reading frame 2 protein (ORF2p)1. ORF2p reverse transcriptase (RT) and endonuclease activities have been implicated in the pathophysiology of cancer2,3, autoimmunity4,5 and ageing6,7, making ORF2p a potential therapeutic target. However, a lack of structural and mechanistic knowledge has hampered ...
作者：Andre, Fabrice; Rassy, Elie; Marabelle, Aurelien; Michiels, Stefan; Besse, Benjamin
作者单位：UNICANCER; Gustave Roussy; Universite Paris Saclay; Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Gustave Roussy; UNICANCER; Gustave Roussy; Universite Paris Saclay; Institut National de la Sante et de la Recherche Medicale (Inserm); UNICANCER; Gustave Roussy; Institut National de la Sante et de la Recherche Medicale (Inserm)
作者：Ferrante, Lucas; Becker, C. Guilherme
作者单位：Universidade Federal de Amazonas; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
作者：Sepp, Mari; Sarropoulos, Ioannis
作者单位：Ruprecht Karls University Heidelberg; Wellcome Trust Sanger Institute
摘要：Tracking the gene-expression profiles of individual cerebellar cells during development in humans, mice and opossums revealed evolutionarily conserved as well as species-specific cellular and molecular features.
