-
作者：Bluvstein, Dolev; Evered, Simon J.; Geim, Alexandra A.; Li, Sophie H.; Zhou, Hengyun; Manovitz, Tom; Ebadi, Sepehr; Cain, Madelyn; Kalinowski, Marcin; Hangleiter, Dominik; Ataides, J. Pablo Bonilla; Maskara, Nishad; Cong, Iris; Gao, Xun; Sales Rodriguez, Pedro; Karolyshyn, Thomas; Semeghini, Giulia; Gullans, Michael J.; Greiner, Markus; Vuletic, Vladan; Lukin, Mikhail D.
作者单位：Harvard University; University System of Maryland; University of Maryland College Park; National Institute of Standards & Technology (NIST) - USA; Harvard University; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
摘要：Suppressing errors is the central challenge for useful quantum computing1, requiring quantum error correction (QEC)2-6 for large-scale processing. However, the overhead in the realization of error-corrected 'logical' qubits, in which information is encoded across many physical qubits for redundancy2-4, poses substantial challenges to large-scale logical quantum computing. Here we report the realization of a programmable quantum processor based on encoded logical qubits operating with up to 280...
-
作者：Thawani, Akanksha; Ariza, Alfredo Jose Florez; Nogales, Eva; Collins, Kathleen
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; Howard Hughes Medical Institute; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：The long interspersed element-1 (LINE-1, hereafter L1) retrotransposon has generated nearly one-third of the human genome and serves as an active source of genetic diversity and human disease1. L1 spreads through a mechanism termed target-primed reverse transcription, in which the encoded enzyme (ORF2p) nicks the target DNA to prime reverse transcription of its own or non-self RNAs2. Here we purified full-length L1 ORF2p and biochemically reconstituted robust target-primed reverse transcriptio...
-
作者：[Anonymous]
摘要：Researchers have a part to play in addressing concerns about government interference in science.
-
作者：[Anonymous]
-
作者：Benzler, Justus
作者单位：Robert Koch Institute
摘要：The risk of catching COVID-19 as calculated by a smartphone app scales with the probability of subsequently testing positive for the coronavirus SARS-CoV-2, showing that digital contact tracing is a useful tool for fighting future pandemics.
-
作者：Obara, Christopher J.; Nixon-Abell, Jonathon; Moore, Andrew S.; Riccio, Federica; Hoffman, David P.; Shtengel, Gleb; Xu, C. Shan; Schaefer, Kathy; Pasolli, H. Amalia; Masson, Jean-Baptiste; Hess, Harald F.; Calderon, Christopher P.; Blackstone, Craig; Lippincott-Schwartz, Jennifer
作者单位：Howard Hughes Medical Institute; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS); Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; Pasteur Network; Universite Paris Cite; Institut Pasteur Paris; University of Colorado System; University of Colorado Boulder; University of London; King's College London; Yale University; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School
摘要：To coordinate cellular physiology, eukaryotic cells rely on the rapid exchange of molecules at specialized organelle-organelle contact sites1,2. Endoplasmic reticulum-mitochondrial contact sites (ERMCSs) are particularly vital communication hubs, playing key roles in the exchange of signalling molecules, lipids and metabolites3,4. ERMCSs are maintained by interactions between complementary tethering molecules on the surface of each organelle5,6. However, due to the extreme sensitivity of these...
-
作者：Denny, Lynette; Kataria, Ishu; Huang, Lisa; Schmeler, Kathleen M.
作者单位：University of Cape Town; Research Triangle Institute; University of Texas System; University of Texas Health Science Center Houston; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas Health Science Center Houston
摘要：Without rapid change, the World Health Organization's goals for tackling cervical cancer by 2030 will be missed. Four experts share ways to move the needle.
-
作者：Li, Yang; Ru, Xiaoning; Yang, Miao; Zheng, Yuhe; Yin, Shi; Hong, Chengjian; Peng, Fuguo; Qu, Minghao; Xue, Chaowei; Lu, Junxiong; Fang, Liang; Su, Chao; Chen, Daifen; Xu, Junhua; Yan, Chao; Li, Zhenguo; Xu, Xixiang; Shao, Zongping
作者单位：Jiangsu University of Science & Technology; Jiangsu University of Science & Technology; Curtin University
摘要：Silicon solar cells are a mainstay of commercialized photovoltaics, and further improving the power conversion efficiency of large-area and flexible cells remains an important research objective1,2. Here we report a combined approach to improving the power conversion efficiency of silicon heterojunction solar cells, while at the same time rendering them flexible. We use low-damage continuous-plasma chemical vapour deposition to prevent epitaxy, self-restoring nanocrystalline sowing and vertica...
-
作者：[Anonymous]
-
作者：Wang, Shuai; Deleon, Chelsea; Sun, Wenfei; Quake, Stephen R.; Roth, Bryan L.; Suedhof, Thomas C.
作者单位：Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford University; Stanford University; Chan Zuckerberg Initiative (CZI)
摘要：The assembly and specification of synapses in the brain is incompletely understood1-3. Latrophilin-3 (encoded by Adgrl3, also known as Lphn3)-a postsynaptic adhesion G-protein-coupled receptor-mediates synapse formation in the hippocampus4 but the mechanisms involved remain unclear. Here we show in mice that LPHN3 organizes synapses through a convergent dual-pathway mechanism: activation of G alpha s signalling and recruitment of phase-separated postsynaptic protein scaffolds. We found that ce...
