6754期

最新文章

• Death Glitch AI翻译
  作者：Henderson, Anna Farro
  作者单位：University of Minnesota System; University of Minnesota Twin Cities
• Now you see me, now you don't AI翻译
  作者：Shawkey, Matthew D.
  作者单位：Ghent University
• A caged drug enables precision delivery AI翻译
  作者：Xie, Yuhao; Chen, Zhe-Sheng
  作者单位：St. John's University
• Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch AI翻译
  作者：Lin, Weifeng; Jia, Xiaohui; Shi, Xiaofeng; He, Qiuya; Zhang, Panyu; Zhang, Xianglei; Zhang, Liping; Wu, Mingqi; Ren, Tengfei; Liu, Yufei; Deng, Haohao; Li, Yanyao; Liu, Shiqi; Huang, Shaoyong; Kang, Jingmin; Luo, Jun; Deng, Ziqing; Wang, Wei
  作者单位：National Institute of Biological Sciences, Beijing; Tsinghua University; China Agricultural University; Northwest A&F University - China; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College
  摘要：Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell and spatial transcriptomic analyses of rabbits and mice recovering from pinna damage. Insufficient retinoic acid (RA) production, caused by the deficiency of rate-limiting enzyme Aldh1a2 and boosted RA degradation, was responsible for the failure of mouse pinna regeneration. Switching on Aldh1a2 o...
• Structural basis of BAX pore formation AI翻译
  作者：Zhang, Ying; Tian, Lu; Huang, Gaoxingyu; Ge, Xiaofei; Kong, Fang; Wang, Pengqi; Xu, Yige; Shi, Yigong
  作者单位：Tsinghua University; Westlake Laboratory; Westlake University; Westlake University; Westlake University; Tsinghua University
  摘要：During apoptosis, cytosolic BAX monomers are translocated to the mitochondria to permeabilize the outer membrane. Here, we identified a dimer of BAX dimers as the basic repeating unit of its various oligomeric forms: arcs, lines, and rings. Cryo-electron microscopy structure of the BAX repeating unit at 3.2-angstrom resolution revealed the interactions within and between dimers. End-to-end stacking of the repeating units through the protruding alpha 9 pairs yielded lines, arcs, polygons, and r...
• Genomic insights into social life in Neolithic Anatolia AI翻译
  作者：Arbuckle, Benjamin S.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
• Evidence for Hadean mafic intrusions in the Nuvvuagittuq Greenstone Belt, Canada AI翻译
  作者：Sole, C.; O'Neil, J.; Rizo, H.; Paquette, J. -L; Benn, D.; Plakholm, J.
  作者单位：University of Ottawa; Carleton University; University of Ottawa; Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Universite Clermont Auvergne (UCA)
  摘要：Many questions remain regarding Earth's earliest crust owing to the rarity of Hadean (>4.03 billion-year-old) rocks and minerals. The Nuvvuagittuq Greenstone Belt (NGB) in Canada may be the only known remnant of Hadean crust, although its age is debated, ranging from >= 3.75 to 4.3 billion years old. Mafic intrusions within this belt were specifically sampled and analyzed to investigate the timing of their magmatic differentiation. Correlations between samarium/neodymium (Sm/Nd) and Nd-143/Nd-...
• Tumors may get energy boost from nerve cells' mitochondria AI翻译
  作者：Leslie, Mitch
• Producing hunger AI翻译
  作者：Stark, Laura
  作者单位：Vanderbilt University
• Cascading land surface hazards as a nexus in the Earth system AI翻译
  作者：Yanites, Brian J.; Clark, Marin K.; Roering, Joshua J.; West, A. Joshua; Zekkos, Dimitrios; Baldwin, Jane W.; Cerovski-Darriau, Corina; Gallen, Sean F.; Horton, Daniel E.; Kirby, Eric; Leshchinsky, Ben A.; Mason, H. Benjamin; Moon, Seulgi; Barnhart, Katherine R.; Booth, Adam; Czuba, Jonathan A.; McCoy, Scott; McGuire, Luke; Pfeiffer, Allison; Pierce, Jennifer
  作者单位：Indiana University System; Indiana University Bloomington; University of Michigan System; University of Michigan; University of Oregon; University of Southern California; University of California System; University of California Berkeley; University of California System; University of California Irvine; Columbia University; United States Department of the Interior; United States Geological Survey; Colorado State University System; Colorado State University Fort Collins; Northwestern University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Oregon State University; Nevada System of Higher Education (NSHE); University of Nevada Reno; University of California System; University of California Los Angeles; Portland State University; Virginia Polytechnic Institute & State University; University of Arizona; Western Washington University; Boise State University
  摘要：This Review synthesizes progress and outlines a new framework for understanding how land surface hazards interact and propagate as sediment cascades across Earth's surface, influenced by interactions among the atmosphere, biosphere, hydrosphere, and solid Earth. Recent research highlights a gap in understanding these interactions on human timescales, given rapid climatic change and urban expansion into hazard-prone zones. We review how surface processes such as coseismic landslides and post-fi...