作者:Sorrell, Erin M.; Kromm, Michelle; Gronvall, Gigi; Pekosz, Andrew; Davis, Meghan F.
作者单位:Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health
作者:Yamamoto, Naoki; Wada, Kaito
作者单位:Keio University
作者:Dumitru, Ionut; Paterlini, Marta; Zamboni, Margherita; Ziegenhain, Christoph; Giatrellis, Sarantis; Saghaleyni, Rasool; Bjoerklund, Asa; Alkass, Kanar; Tata, Mathew; Druid, Henrik; Sandberg, Rickard; Frisen, Jonas
作者单位:Karolinska Institutet; Chalmers University of Technology; Karolinska Institutet; Karolinska Institutet; Cancer Research UK
摘要:Continuous adult hippocampal neurogenesis is involved in memory formation and mood regulation but is challenging to study in humans. Difficulties finding proliferating progenitor cells called into question whether and how new neurons may be generated. We analyzed the human hippocampus from birth through adulthood by single-nucleus RNA sequencing. We identified all neural progenitor cell stages in early childhood. In adults, using antibodies against the proliferation marker Ki67 and machine lea...