8001期

最新文章

• Can non-profits beat antibiotic resistance and soaring drug costs? AI翻译
  作者：McKenna, Maryn
  摘要：Effective, affordable antimicrobial drugs aren't moneymakers, despite being desperately needed. Can non-profit organizations pick up the slack?
• From the archive: Stephen Hawking's explosive idea, and scientific spirit AI翻译
  作者：Efimov, Igor R.
  摘要：Snippets from Nature's past.
• Ion and lipid orchestration of secondary active transport AI翻译
  作者：Drew, David; Boudker, Olga
  作者单位：Stockholm University; Cornell University; Weill Cornell Medicine; Howard Hughes Medical Institute; Cornell University; Weill Cornell Medicine
  摘要：Transporting small molecules across cell membranes is an essential process in cell physiology. Many structurally diverse, secondary active transporters harness transmembrane electrochemical gradients of ions to power the uptake or efflux of nutrients, signalling molecules, drugs and other ions across cell membranes. Transporters reside in lipid bilayers on the interface between two aqueous compartments, where they are energized and regulated by symported, antiported and allosteric ions on both...
• A distinct cortical code for socially learned threat AI翻译
  作者：Silverstein, Shana E.; O'Sullivan, Ruairi; Bukalo, Olena; Pati, Dipanwita; Schaffer, Julia A.; Limoges, Aaron; Zsembik, Leo; Yoshida, Takayuki; O'Malley, John J.; Paletzki, Ronald F.; Lieberman, Abby G.; Nonaka, Mio; Deisseroth, Karl; Gerfen, Charles R.; Penzo, Mario A.; Kash, Thomas L.; Holmes, Andrew
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA); University of North Carolina; University of North Carolina Chapel Hill; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); Stanford University; Stanford University; Stanford University; Howard Hughes Medical Institute
  摘要：Animals can learn about sources of danger while minimizing their own risk by observing how others respond to threats. However, the distinct neural mechanisms by which threats are learned through social observation (known as observational fear learning1-4 (OFL)) to generate behavioural responses specific to such threats remain poorly understood. The dorsomedial prefrontal cortex (dmPFC) performs several key functions that may underlie OFL, including processing of social information and disambig...
• Self-assembling synthetic polymer forms liquid-like droplets AI翻译
  作者：Ross, Jennifer L.
  作者单位：Syracuse University
• A new family of bacterial ribosome hibernation factors AI翻译
  作者：Helena-Bueno, Karla; Rybak, Mariia Yu.; Ekemezie, Chinenye L.; Sullivan, Rudi; Brown, Charlotte R.; Dingwall, Charlotte; Basle, Arnaud; Schneider, Claudia; Connolly, James P. R.; Blaza, James N.; Csoergo, Balint; Moynihan, Patrick J.; Gagnon, Matthieu G.; Hill, Chris H.; Melnikov, Sergey V.
  作者单位：Newcastle University - UK; University of Texas System; University of Texas Medical Branch Galveston; University of Birmingham; University of York - UK; University of York - UK; University of York - UK; HUN-REN; HUN-REN Biological Research Center; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; University of Texas System; University of Texas Medical Branch Galveston; University of York - UK
  摘要：To conserve energy during starvation and stress, many organisms use hibernation factor proteins to inhibit protein synthesis and protect their ribosomes from damage1,2. In bacteria, two families of hibernation factors have been described, but the low conservation of these proteins and the huge diversity of species, habitats and environmental stressors have confounded their discovery3-6. Here, by combining cryogenic electron microscopy, genetics and biochemistry, we identify Balon, a new hibern...
• A model of human neural networks reveals NPTX2 pathology in ALS and FTLD AI翻译
  作者：Hruska-Plochan, Marian; Wiersma, Vera I.; Betz, Katharina M.; Mallona, Izaskun; Ronchi, Silvia; Maniecka, Zuzanna; Hock, Eva-Maria; Tantardini, Elena; Laferriere, Florent; Sahadevan, Sonu; Hoop, Vanessa; Delvendahl, Igor; Perez-Berlanga, Manuela; Gatta, Beatrice; Panatta, Martina; van der Bourg, Alexander; Bohaciakova, Dasa; Sharma, Puneet; De Vos, Laura; Frontzek, Karl; Aguzzi, Adriano; Lashley, Tammaryn; Robinson, Mark D.; Karayannis, Theofanis; Mueller, Martin; Hierlemann, Andreas; Polymenidou, Magdalini
  作者单位：University of Zurich; University of Zurich; Swiss Institute of Bioinformatics; University of Zurich; University of Zurich; Masaryk University; University of Bern; University of Zurich; University of London; University College London; University of London; University College London
  摘要：Human cellular models of neurodegeneration require reproducibility and longevity, which is necessary for simulating age-dependent diseases. Such systems are particularly needed for TDP-43 proteinopathies1, which involve human-specific mechanisms2-5 that cannot be directly studied in animal models. Here, to explore the emergence and consequences of TDP-43 pathologies, we generated induced pluripotent stem cell-derived, colony morphology neural stem cells (iCoMoNSCs) via manual selection of neur...
• Why citizen scientists are gathering DNA from hundreds of lakes - on the same day AI翻译
  作者：Larsen, Lydia
  摘要：Massive environmental DNA project will take a record-setting snapshot of biodiversity worldwide.
• Save lives in the next pandemic: ensure vaccine equity now AI翻译
  作者：Carlson, Colin; Becker, Daniel; Happi, Christian; O'Donoghue, Zoe; de Oliveira, Tulio; Oyola, Samuel O.; Poisot, Timothee; Seifert, Stephanie; Phelan, Alexandra
  作者单位：Georgetown University; University of Oklahoma System; University of Oklahoma - Norman; Redeemers University; Redeemers University; Stellenbosch University; Stellenbosch University; University of Kwazulu Natal; CGIAR; International Livestock Research Institute (ILRI); CGIAR; International Livestock Research Institute (ILRI); Universite de Montreal; Washington State University; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health
  摘要：The proposed Pandemic Agreement must ensure that COVID-19 vaccine nationalism is never repeated; 290 scientists call for action. The proposed Pandemic Agreement must ensure that COVID-19 vaccine nationalism is never repeated; 290 scientists call for action.
• CEACAM1 regulates TIM-3-mediated tolerance and exhaustion AI翻译
  作者：Huang, Yu-Hwa; Zhu, Chen; Kondo, Yasuyuki; Anderson, Ana C.; Gandhi, Amit; Russell, Andrew; Dougan, Stephanie K.; Petersen, Britt-Sabina; Melum, Espen; Pertel, Thomas; Clayton, Kiera L.; Raab, Monika; Chen, Qiang; Beauchemin, Nicole; Yazaki, Paul J.; Pyzik, Michal; Ostrowski, Mario A.; Glickman, Jonathan N.; Rudd, Christopher E.; Ploegh, Hidde L.; Franke, Andre; Petsko, Gregory A.; Kuchroo, Vijay K.; Blumberg, Richard S.