6758期

最新文章

• Genetics, energetics, and allostery in proteins with randomized cores and surfaces AI翻译
  作者：Escobedo, Albert; Voigt, Gesa; Faure, Andre J.; Lehner, Ben
  作者单位：Pompeu Fabra University; Barcelona Institute of Science & Technology; Centre de Regulacio Genomica (CRG); Wellcome Trust Sanger Institute; Pompeu Fabra University; ICREA
  摘要：A lack of systematic experimental data limits our understanding of protein evolution. In this study, we experimentally characterized proteins with randomized sequences. Vast numbers of amino acid combinations constitute stable protein cores and surfaces. However, alternative cores frequently disrupt protein function by indirect allosteric effects. Both protein stability and binding can be predicted using simple additive energy models with a small contribution from pairwise energetic couplings....
• Weaponizing Europe's borders imperils wildlife AI翻译
  作者：Nowak, Katarzyna; Cerri, Jacopo; Kudrenko, Svitlana; Kopatz, Alexander; Stachowicz, Izabela; Selva, Nuria; Berhe, Asmeret Asefaw; Kojola, Ilpo; Sprem, Nikica
  作者单位：Polish Academy of Sciences; Mammal Research Institute of the Polish Academy of Sciences; Norwegian University of Life Sciences; Norwegian Institute Nature Research; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Estacion Biologica de Donana (EBD); Polish Academy of Sciences; Universidad de Huelva; University of California System; University of California Merced; Natural Resources Institute Finland (Luke); University of Zagreb
• New scheme for overhead payments faces doubts AI翻译
  作者：Mervis, Jeffrey
• Little-to-no industrial fishing occurs in fully and highly protected marine areas AI翻译
  作者：Raynor, Jennifer; Orofino, Sara; Costello, Christopher; McDonald, Gavin; Mayorga, Juan; Sala, Enric
  作者单位：University of Wisconsin System; University of Wisconsin Madison; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; National Geographic Society
  摘要：There is a widespread perception that illegal fishing is common in marine protected areas (MPAs) due to strong incentives for poaching and the high cost of monitoring and enforcement. Using artificial intelligence and satellite-based Earth observations, we provide estimates of industrial fishing activity in fully and highly protected MPAs worldwide, in which such fishing is banned. We find little to no activity in most cases. On average, these MPAs had just one fishing vessel present per 20,00...
• Beyond the native repertoire AI翻译
  作者：Hickok, Grant H.; Stromnes, Ingunn M.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
• De novo-designed pMHC binders facilitate T cell-mediated cytotoxicity toward cancer cells AI翻译
  作者：Johansen, Kristoffer Haurum; Wolff, Darian Stephan; Scapolo, Beatrice; Fernandez-Quintero, Monica L.; Christensen, Charlotte Risager; Loeffler, Johannes R.; Rivera-de-Torre, Esperanza; Overath, Max D.; Munk, Kamilla Kjaergaard; Morell, Oliver; Viuff, Marie Christine; Lacunza, Inigo; Englund, Alberte T. Damm; Due, Mathilde; Gharpure, Anant; Forli, Stefano; Pardo, Carlos Rodriguez; Tamhane, Tripti; Andersen, Emma Qingjie; Bjoernsson, Kasper Haldrup; Fernandes, Jordan Sylvester; Voss, Lasse Frank; Thumtecho, Suthimon; Ward, Andrew B.; Ormhoj, Maria; Hadrup, Sine Reker; Jenkins, Timothy P.
  作者单位：Technical University of Denmark; Technical University of Denmark; Scripps Research Institute
  摘要：The recognition of intracellular antigens by CD8+ T cells through T cell receptors (TCRs) is central for adaptive immunity against infections and cancer. However, the identification of TCRs from patient material remains complex. We present a rapid de novo minibinder (miBd) design platform leveraging state-of-the-art generative models to engineer miBds targeting the cancer-associated peptide-bound major histocompatibility complex (pMHC) SLLMWITQC/HLA-A*02:01 (NY-ESO-1). Incorporating in silico ...
• Global patterns and drivers of untracked industrial fishing in coastal marine protected areas AI翻译
  作者：Seguin, Raphael; Le Manach, Frederic; Devillers, Rodolphe; Velez, Laure; Mouillot, David
  作者单位：Institut de Recherche pour le Developpement (IRD); Centre National de la Recherche Scientifique (CNRS); Ifremer; Universite de Montpellier; Universite de Montpellier; University of La Reunion
  摘要：Marine protected areas (MPAs) are expanding worldwide, but industrial fishing within their boundaries remains poorly understood. By combining vessel Global Positioning System data with satellite imagery, we detected industrial fishing in 47% of coastal MPAs worldwide between 2022 and 2024, with two-thirds of vessel detections (67%) untracked by public monitoring. These untracked vessels were most prevalent (80%) in MPAs with the most restrictive management category, which aims to prohibit all ...
• Flat optics produces quantum graphs AI翻译
  作者：Shcherbakov, Maxim R.
  作者单位：University of California System; University of California Irvine
• Why AI chatbots lie to us AI翻译
  作者：Mitchell, Melanie
• BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction AI翻译
  作者：Simanshu, Dhirendra K.; Xu, Rui; Stice, James P.; Czyzyk, Daniel J.; Feng, Siyu; Denson, John-Paul; Riegler, Erin; Yang, Yue; Zhang, Cathy; Donovan, Sofia; Smith, Brian P.; Abreu-Blanco, Maria; Chen, Ming; Feng, Cindy; Fu, Lijuan; Rabara, Dana; Young, Lucy C.; Dyba, Marcin; Yan, Wupeng; Lin, Ken; Ghorbanpoorvalukolaie, Samar; Larsen, Erik K.; Malik, Wafa; Champagne, Allison; Parker, Katie; Ju, Jin Hyun; Jeknic, Stevan; Esposito, Dominic; Turner, David M.; Lightstone, Felice C.; Wang, Bin; Wehn, Paul M.; Wang, Keshi; Stephen, Andrew G.; Maciag, Anna E.; Hata, Aaron N.; Sinkevicius, Kerstin W.; Nissley, Dwight V.; Wallace, Eli M.; McCormick, Frank; Beltran, Pedro J.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; United States Department of Energy (DOE); Lawrence Livermore National Laboratory; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School
  摘要：BBO-10203 is an orally available drug that covalently and specifically binds to the rat sarcoma (RAS)-binding domain of phosphoinositide 3-kinase alpha (PI3K alpha), preventing its activation by HRAS, NRAS, and KRAS. It inhibited PI3K alpha activation in tumors with oncogenic mutations in KRAS or PIK3CA and in tumors with human epidermal growth factor receptor 2 (HER2) amplification or overexpression. In preclinical models, BBO-10203 caused significant tumor growth inhibition across multiple t...