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作者：Solinas, Giovanni
作者单位：University of Gothenburg
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作者：Black, Riley
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作者：Gibbons, Ann
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作者：Lopopolo, Maria; Avanzi, Charlotte; Duchene, Sebastian; Luisi, Pierre; de Flamingh, Alida; Ponce-Soto, Gabriel Yaxal; Tressieres, Gaetan; Neumeyer, Sarah; Lemoine, Frederic; Nelson, Elizabeth A.; Iraeta-Orbegozo, Miren; Cybulski, Jerome S.; Mitchell, Joycelynn; Marks, Vilma T.; Adams, Linda B.; Lindo, John; Degiorgio, Michael; Ortiz, Nery; Wiens, Carlos; Hiebert, Juri; Bonifaz, Alexandro; Montes de Oca, Griselda; Paredes-Solis, Vanessa; Franco-Paredes, Carlos; Vera-Cabrera, Lucio; Pereira Brunelli, Jose G.; Jackson, Mary; Spencer, John S.; Salgado, Claudio G.; Han, Xiang-Yang; Pearce, Camron M.; Warren, Alaine K.; Rosa, Patricia S.; de Finardi, Amanda J.; Belone, Andrea de F. F.; Ferreira, Cynthia; Suffys, Philip N.; Fontes, Amanda N. Brum; Vasconcellos, Sidra E. G.; Schaub, Roxane; Couppie, Pierre; Drak Alsibai, Kinan; Hernandez-Castro, Rigoberto; Silva Miranda, Mayra; Estrada-Garcia, Iris; Jurado-Santacruz, Fermin; Orlando, Ludovic; Schroeder, Hannes; Quintana-Murci, Lluis; Del Papa, Mariano; Lahiri, Ramanuj; Malhi, Ripan S.; Rasmussen, Simon; Rascovan, Nicolas
作者单位：Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Pasteur Network; Institut Pasteur Paris; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Colorado State University System; Colorado State University Fort Collins; Universite Paris Cite; Pasteur Network; Institut Pasteur Paris; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); National University of Cordoba; National University of Cordoba; University of Illinois System; University of Illinois Urbana-Champaign; Communaute d'universites et etablissements de Toulouse (Comue); Universite de Toulouse (EPE); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); University of Copenhagen; United States Health Resources & Service Administration (HRSA); Emory University; State University System of Florida; Florida Atlantic University; Hospital Infantil de Mexico Federico Gomez; Universidad Autonoma de Nuevo Leon; Universidade Federal do Para; University of Texas System; UTMD Anderson Cancer Center; Universidade do Estado do Amazonas; Fundacao Oswaldo Cruz; Institut National de la Sante et de la Recherche Medicale (Inserm); Andree-Rosemon Hospital; Andree-Rosemon Hospital; Instituto Politecnico Nacional - Mexico; Universite Paris Cite; Pasteur Network; Centre National de la Recherche Scientifique (CNRS); Institut Pasteur Paris; Universite PSL; College de France; National University of La Plata; University of Copenhagen; Novo Nordisk Foundation; Southern Methodist University
摘要：Leprosy, caused primarily by Mycobacterium leprae, is considered a disease introduced into the Americas during European colonization. However, the recent discovery of a second pathogen causing leprosy, M. lepromatosis, mainly found in the Americas, challenges this view. Here, we show that M. lepromatosis infected humans in the Americas before European contact. By screening 389 ancient and 408 contemporary samples, we have expanded the genetic data available for the species. Phylogenetic analys...
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作者：Susi, Toma
作者单位：University of Vienna
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作者：Vignieri, Sacha; Ross, Sarah H.; Jiang, Di; Lavine, Marc S.; Suleymanov, Yury; Hurtley, Stella M.; Smith, Keith T.
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作者：Terayama, Koji; Furuzono, Shinji; Fer, Nicole; Yan, Wupeng; Young, Lucy C.; Czyzyk, Daniel J.; Goldstein de Salazar, Ruby; Sasaki, Masato; Uozumi, Akihiro; Konishi, Masahiro; Kanda, Shoichi; Sogawa, Yoshitaka; Yamaguchi, Mitsuhiro; Tsuji, Takashi; Kuroyanagi, Junichi; Hayashi, Mayumi; Ogura, Yuji; Simanshu, Dhirendra K.; Kubota, Kazuishi; Tanaka, Jun; McCormick, Frank
作者单位：Daiichi Sankyo Company Limited; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; Daiichi Sankyo Company Limited; Daiichi Sankyo Company Limited; Daiichi Sankyo Company Limited
摘要：While exploring strategies to control blood glucose concentrations in diabetes, we identified so-called molecular glues D223 and D927 that promote glucose uptake in the absence of insulin. They act by increasing the binding affinity of phosphoinositide 3-kinase alpha (PI3K alpha) catalytic subunit p110 alpha to canonical small guanosine triphosphatase RAS proteins and to RRAS, RRAS2, and MRAS by three orders of magnitude. The compounds bind to the RAS-binding domain of p110 alpha, stabilizing ...
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作者：Yousef, Kerolos M. A.; D'Alessandro, Marco; Yeh, Matthew; Sinclair, Neil; Loncar, Marko; Capasso, Federico
作者单位：Harvard University
摘要：Multiphoton interference and entanglement are fundamental to quantum information science, yet extending these effects to higher-dimensional systems remains challenging given the imperfections and complexity of scaling conventional linear-optical setups. We present a generalized Hong-Ou-Mandel effect using metasurfaces and graph theory, achieving controlled multiphoton bunching, antibunching, and entanglement across parallel Jones matrix-encoded spatial modes-all within a single-layer metasurfa...
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作者：Wang, Guangzhou; van der Putten, Wim H.; Klironomos, John; Zhang, Fusuo; Zhang, Junling
作者单位：China Agricultural University; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute of Ecology (NIOO-KNAW); Wageningen University & Research; American University of Sharjah
摘要：The challenge of producing food at low monetary cost comes with high environmental impacts as yield maximization by excessive fertilization and chemical pest control drive farmers away from using the natural multifunctional potential of soils. We show how the ecological concept of plant-soil feedback can be used to restore the capacity of agricultural soils to provide nutrients, suppress pathogens, and enhance crop resilience sustainably. We review how recent advances in molecular and multiomi...
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作者：Liu, Bingxu; Greenwood, Nathan F.; Bonzanini, Julia E.; Motmaen, Amir; Meyerberg, Jeremy; Dao, Tao; Xiang, Xinyu; Ault, Russell; Sharp, Jazmin; Wang, Chunyu; Visani, Gian Marco; Vafeados, Dionne K.; Roullier, Nicole; Nourmohammad, Armita; Scheinberg, David A.; Garcia, K. Christopher; Baker, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Memorial Sloan Kettering Cancer Center; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; Pennsylvania Medicine; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; Cornell University; Weill Cornell Medicine; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle
摘要：Class I major histocompatibility complex (MHC-I) molecules present peptides derived from intracellular antigens on the cell surface for immune surveillance. Proteins that recognize peptide-MHC-I (pMHCI) complexes with specificity for diseased cells could have considerable therapeutic utility. Specificity requires recognition of outward-facing amino acid residues within the disease-associated peptide as well as avoidance of extensive contacts with ubiquitously expressed MHC. We used RFdiffusion...
