6758期

最新文章

• A neomorphic protein interface catalyzes covalent inhibition of RASG12D aspartic acid in tumors AI翻译
  作者：Weller, Caroline; Burnett, G. Leslie; Jiang, Lingyan; Chakraborty, Sujata; Zhang, Dongyu; Vita, Nicole A.; Dilly, Julien; Kim, Eejung; Maldonato, Benjamin; Seamon, Kyle; Eilerts, Diane F.; Milin, Anthony; Marquez, Abby; Spradlin, Jessica; Helland, Ciara; Gould, Andrea; Ziv, Tamar Bar; Dinh, Phuong; Steele, Shelby L.; Wang, Zhican; Mu, Yunming; Chugh, Seema; Feng, Hanrong; Hennessey, Conner; Wang, Junning; Roth, Jennifer; Rees, Matthew; Ronan, Melissa; Wolpin, Brian M.; Hahn, William C.; Holderfield, Matthew; Wang, Zhengping; Koltun, Elena S.; Singh, Mallika; Gill, Adrian L.; Smith, Jacqueline A. M.; Aguirre, Andrew J.; Jiang, Jingjing; Knox, John E.; Wildes, David
  作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT)
  摘要：Mutant RAS proteins are among the most prevalent drivers of human cancer, and the glycine to aspartic acid mutation at codon 12 (G12D) is the most common variant. Mutation-selective covalent inhibitors spare RAS in healthy tissue and enable extended pharmacodynamic effect, but covalent targeting of RASG12D is hindered by low nucleophilicity and high proteomic abundance of carboxylic acids. We overcame these challenges with compounds that bind cyclophilin A (CYPA) to create a neomorphic protein...
• NASA Earth Science Division provides key data AI翻译
  作者：Millet, Dylan B.; Demoz, Belay B.; Watts, Jennifer D.; Wright, Robert
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University System of Maryland; University of Maryland Baltimore County; University of Hawaii System; University of Hawaii Manoa
• Proactive assisted gene flow for Caribbean corals in an era of rapid coral reef decline AI翻译
  作者：Baker, Andrew C.; Baums, Iliana B.; Davies, Sarah W.; Grottoli, Andrea G.; Kenkel, Carly D.; Kitchen, Sheila A.; Kuffner, Ilsa B.; Matz, Mikhail V.; Miller, Margaret W.; Muller, Erinn M.; Parkinson, John E.; Prada, Carlos; Shantz, Andrew A.; Hooidonk, Ruben van; Winters, Scott
  作者单位：University of Miami; Carl von Ossietzky Universitat Oldenburg; Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Carl von Ossietzky Universitat Oldenburg; Boston University; University System of Ohio; Ohio State University; University of Southern California; Texas A&M University System; United States Department of the Interior; United States Geological Survey; University of Texas System; University of Texas Austin; Mote Marine Laboratory & Aquarium; State University System of Florida; University of South Florida; University of Rhode Island; University of Hawaii System; University of Hawaii Manoa; University of Oxford
• Dinner with King Tut AI翻译
  作者：McGovern, Patrick E.
  作者单位：University of Pennsylvania; University of Pennsylvania
• All-sky radio telescopes ditch the dish AI翻译
  作者：Normile, Dennis
• Running out of road AI翻译
  作者：Zhao, Na
  作者单位：Baylor College of Medicine
• Reinstate the National Climate Assessment AI翻译
  作者：Landry, Craig E.; Lewis, Lynne; Mcdermott, Shana; Vander Naald, Brian; Smith, Martin D.; Whitehead, John C.
  作者单位：University System of Georgia; University of Georgia; Colorado State University System; Colorado State University Fort Collins; University of Missouri System; University of Missouri Columbia; Drake University; Duke University; University of North Carolina; Appalachian State University
• Science retracts 'arsenic life' paper despite protests AI翻译
  作者：Offord, Catherine
• De novo design and structure of a peptide-centric TCR mimic binding module AI翻译
  作者：Householder, Karsten D.; Xiang, Xinyu; Jude, Kevin M.; Deng, Arthur; Obenaus, Matthias; Zhao, Yang; Wilson, Steven C.; Chen, Xiaojing; Wang, Nan; Garcia, K. Christopher
  作者单位：Stanford Medicine; Stanford University; Stanford University; Stanford Medicine; Stanford University; Stanford Medicine; Stanford University; Howard Hughes Medical Institute; Stanford University; Stanford Medicine
  摘要：T cell receptor (TCR) mimics offer a promising platform for tumor-specific targeting of peptide-major histocompatibility complex (pMHC) in cancer immunotherapy. In this study, we designed a de novo alpha-helical TCR mimic (TCRm) specific for the NY-ESO-1 peptide presented by human leukocyte antigen (HLA)-A*02, achieving high on-target specificity with nanomolar affinity (dissociation constant Kd = 9.5 nM). The structure of the TCRm-pMHC complex at 2.05-& Aring; resolution revealed a rigid TCR-...
• EPA begins to dismantle its research office AI翻译
  作者：Stokstad, Erik