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作者：Kronenfeld, Jason M.; Rother, Lukas; Saccone, Max A.; Dulay, Maria T.; DeSimone, Joseph M.
作者单位：Stanford University; Stanford University; Stanford University
摘要：Particle fabrication has attracted recent attention owing to its diverse applications in bioengineering1,2, drug and vaccine delivery3-5, microfluidics6,7, granular systems8,9, self-assembly5,10,11, microelectronics12,13 and abrasives14. Herein we introduce a scalable, high-resolution, 3D printing technique for the fabrication of shape-specific particles based on roll-to-roll continuous liquid interface production (r2rCLIP). We demonstrate r2rCLIP using single-digit, micron-resolution optics i...
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作者：Mangurian, Christina; Brindis, Claire D.
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：Without action, parity is still half a century away. We cannot afford to wait that long.
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作者：Sherwin, Evan D.; Rutherford, Jeffrey S.; Zhang, Zhan; Chen, Yuanlei; Wetherley, Erin B.; Yakovlev, Petr V.; Berman, Elena S. F.; Jones, Brian B.; Cusworth, Daniel H.; Thorpe, Andrew K.; Ayasse, Alana K.; Duren, Riley M.; Brandt, Adam R.
作者单位：Stanford University; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL); California Institute of Technology; University of Arizona; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：As airborne methane surveys of oil and gas systems continue to discover large emissions that are missing from official estimates1-4, the true scope of methane emissions from energy production has yet to be quantified. We integrate approximately one million aerial site measurements into regional emissions inventories for six regions in the USA, comprising 52% of onshore oil and 29% of gas production over 15 aerial campaigns. We construct complete emissions distributions for each, employing empi...
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作者：Telford, Max; Hejnol, Andreas; Arendt, Detlev
作者单位：University of London; University College London; Friedrich Schiller University of Jena; European Molecular Biology Laboratory (EMBL)
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作者：Weng, Chen; Yu, Fulong; Yang, Dian; Poeschla, Michael; Liggett, L. Alexander; Jones, Matthew G.; Qiu, Xiaojie; Wahlster, Lara; Caulier, Alexis; Hussmann, Jeffrey A.; Schnell, Alexandra; Yost, Kathryn E.; Koblan, Luke W.; Martin-Rufino, Jorge D.; Min, Joseph; Hammond, Alessandro; Ssozi, Daniel; Bueno, Raphael; Mallidi, Hari; Kreso, Antonia; Escabi, Javier; Rideout, William M.; Jacks, Tyler; Hormoz, Sahand; van Galen, Peter; Weissman, Jonathan S.; Sankaran, Vijay G.
作者单位：Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; Massachusetts Institute of Technology (MIT); Whitehead Institute; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; Massachusetts Institute of Technology (MIT); Stanford University; Stanford University; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Massachusetts Institute of Technology (MIT); Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Guangzhou Medical University; State Key Laboratory of Respiratory Disease; Columbia University; Stanford University
摘要：The human blood system is maintained through the differentiation and massive amplification of a limited number of long-lived haematopoietic stem cells (HSCs)1. Perturbations to this process underlie diverse diseases, but the clonal contributions to human haematopoiesis and how this changes with age remain incompletely understood. Although recent insights have emerged from barcoding studies in model systems2-5, simultaneous detection of cell states and phylogenies from natural barcodes in human...
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作者：[Anonymous]
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作者：Xu, Bingxin; Chen, Zaijun; Haensch, Theodor W.; Picque, Nathalie
作者单位：Max Planck Society; University of Munich; Leibniz Association; Max Born Institute for Nonlinear Optics & Short Term Spectroscopy; University of Southern California
摘要：Ultraviolet spectroscopy provides unique insights into the structure of matter with applications ranging from fundamental tests to photochemistry in the Earth's atmosphere and astronomical observations from space telescopes(1-8). At longer wavelengths, dual-comb spectroscopy, using two interfering laser frequency combs, has become a powerful technique capable of simultaneously providing a broad spectral range and very high resolution(9). Here we demonstrate a photon-counting approach that can ...
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作者：Ollivier, Matthias; Soto, Joselyn S.; Linker, Kay E.; Moye, Stefanie L.; Jami-Alahmadi, Yasaman; Jones, Anthony E.; Divakaruni, Ajit S.; Kawaguchi, Riki; Wohlschlegel, James A.; Khakh, Baljit S.
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA
摘要：Astrocytes are heterogeneous glial cells of the central nervous system(1-3). However, the physiological relevance of astrocyte diversity for neural circuits and behaviour remains unclear. Here we show that a specific population of astrocytes in the central striatum expresses mu-crystallin (encoded by Crym in mice and CRYM in humans) that is associated with several human diseases, including neuropsychiatric disorders(4-7). In adult mice, reducing the levels of mu-crystallin in striatal astrocyt...
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作者：Nakandakari-Higa, Sandra; Walker, Sarah; Canesso, Maria C. C.; van der Heide, Verena; Chudnovskiy, Aleksey; Kim, Dong-Yoon; Jacobsen, Johanne T.; Parsa, Roham; Bilanovic, Jana; Parigi, S. Martina; Fiedorczuk, Karol; Fuchs, Elaine; Bilate, Angelina M.; Pasqual, Giulia; Mucida, Daniel; Kamphorst, Alice O.; Pritykin, Yuri; Victora, Gabriel D.
作者单位：Rockefeller University; Princeton University; Princeton University; Rockefeller University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Rockefeller University; Rockefeller University; Rockefeller University; Howard Hughes Medical Institute; University of Padua; Princeton University; University of Oslo; National Hospital Norway
摘要：Immune cells rely on transient physical interactions with other immune and non-immune populations to regulate their function(1). To study these 'kiss-and-run' interactions directly in vivo, we previously developed LIPSTIC (labelling immune partnerships by SorTagging intercellular contacts)(2), an approach that uses enzymatic transfer of a labelled substrate between the molecular partners CD40L and CD40 to label interacting cells. Reliance on this pathway limited the use of LIPSTIC to measuring...
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作者：Wheeler, Michael A.
作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard Medical School
摘要：Direct interactions between cells in tissue are incompletely understood because the advanced technologies required to examine them are still in their infancy. A new method can decipher cell-cell interactions on a large scale.
