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作者：Wang, Chao; Tang, Ren-Jie; Kou, Senhao; Xu, Xiaoshu; Lu, Yi; Rauscher, Kenda; Voelker, Angela; Luan, Sheng
作者单位：University of California System; University of California Berkeley; Stanford University; University of California System; University of California Berkeley
摘要：Calcium (Ca2+) is an essential nutrient for plants and a cellular signal, but excessive levels can be toxic and inhibit growth1,2. To thrive in dynamic environments, plants must monitor and maintain cytosolic Ca2+ homeostasis by regulating numerous Ca2+ transporters3. Here we report two signalling pathways in Arabidopsis thaliana that converge on the activation of vacuolar Ca2+/H+ exchangers (CAXs) to scavenge excess cytosolic Ca2+ in plants. One mechanism, activated in response to an elevated...
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作者：Kruyer, Anna
作者单位：University System of Ohio; University of Cincinnati; University System of Ohio; University of Cincinnati
摘要：A single gene in astrocytes can constrain repetitive behaviours, indicating that these cells are regulators of behavioural disruption in conditions such as Huntington's disease and obsessive-compulsive disorder.
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作者：Kuan, Aaron T.; Bondanelli, Giulio; Driscoll, Laura N.; Han, Julie; Kim, Minsu; Hildebrand, David G. C.; Graham, Brett J.; Wilson, Daniel E.; Thomas, Logan A.; Panzeri, Stefano; Harvey, Christopher D.; Lee, Wei-Chung Allen
作者单位：Harvard University; Harvard Medical School; Istituto Italiano di Tecnologia - IIT; University of Hamburg; University Medical Center Hamburg-Eppendorf; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Yale University; Allen Institute for Brain Science; Rockefeller University; Space Telescope Science Institute; University of California System; University of California Berkeley
摘要：The posterior parietal cortex exhibits choice-selective activity during perceptual decision-making tasks(1-10). However, it is not known how this selective activity arises from the underlying synaptic connectivity. Here we combined virtual-reality behaviour, two-photon calcium imaging, high-throughput electron microscopy and circuit modelling to analyse how synaptic connectivity between neurons in the posterior parietal cortex relates to their selective activity. We found that excitatory pyram...
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作者：Makhlouf, Linda; Peter, Joshua J.; Magnussen, Helge M.; Thakur, Rohan; Millrine, David; Minshull, Thomas C.; Harrison, Grace; Varghese, Joby; Lamoliatte, Frederic; Foglizzo, Martina; Macartney, Thomas; Calabrese, Antonio N.; Zeqiraj, Elton; Kulathu, Yogesh
作者单位：University of Leeds; University of Dundee
摘要：Stalled ribosomes at the endoplasmic reticulum (ER) are covalently modified with the ubiquitin-like protein UFM1 on the 60S ribosomal subunit protein RPL26 (also known as uL24)(1,2). This modification, which is known as UFMylation, is orchestrated by the UFM1 ribosome E3 ligase (UREL) complex, comprising UFL1, UFBP1 and CDK5RAP3 (ref. (3)). However, the catalytic mechanism of UREL and the functional consequences of UFMylation are unclear. Here we present cryo-electron microscopy structures of ...
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作者：Landhuis, Esther; Yee, Daryl; Claw, Katrina; Schweppe, Devin; Singh, Ankur; Macklin, Paul; Moore, Jonathan; Fertig, Elana; Lee, Myungjae; Zhong, Yu; Garmire, Lana; Zurzolo, Chiara
摘要：Although many postdocs and faculty members are leaving for industry or elsewhere, these researchers tell us why they love the academic life.
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作者：Santos, Charles Morphy D.; Gois, Joao Paulo
作者单位：Universidade Federal do ABC (UFABC)
摘要：Letter to the Editor
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作者：Spiegel, Christoph A.; Blasco, Eva
作者单位：Ruprecht Karls University Heidelberg
摘要：Combining a high-throughput technique with 3D printing offers a way of fabricating micrometre-sized particles for use in electronics and biotechnology. The versatile method can produce one million intricate shapes in a single day.
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作者：Coombs, Amy; Ong, Sandy
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作者：Tamulaitiene, Giedre; Sabonis, Dziugas; Sasnauskas, Giedrius; Ruksenaite, Audrone; Silanskas, Arunas; Avraham, Carmel; Ofir, Gal; Sorek, Rotem; Zaremba, Mindaugas; Siksnys, Virginijus
作者单位：Vilnius University; Weizmann Institute of Science
摘要：To survive bacteriophage (phage) infections, bacteria developed numerous anti-phage defence systems(1-7). Some of them (for example, type III CRISPR-Cas, CBASS, Pycsar and Thoeris) consist of two modules: a sensor responsible for infection recognition and an effector that stops viral replication by destroying key cellular components(8-12). In the Thoeris system, a Toll/interleukin-1 receptor (TIR)-domain protein, ThsB, acts as a sensor that synthesizes an isomer of cyclic ADP ribose, 1 '-3 ' g...
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作者：[Anonymous]
