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作者：Wang, Dalei; Liu, Zixiao; Zhao, Hongping; Qin, Huanqi; Bai, Gongxun; Chen, Chi; Shi, Pengju; Du, Yingjie; Zhao, Yusen; Liu, Wei; Wang, Dan; Zhou, Guoquan; He, Ximin; Dai, Chaoqing
作者单位：Zhejiang A&F University; University of California System; University of California Los Angeles; China Jiliang University; Anhui University of Technology
摘要：Cavitation, characterized by formation of vapor bubbles in a low-pressure or high-temperature region of a liquid, is often destructive, but it can be harnessed for actuators and robots. We exploit cavitation to accumulate substantial energy in superheated liquids by suppressing its immediate release until reaching a stability limit. The energetic, unstable bubbles collapse violently, producing a burst of high power and force that initiates motion. Notably, a millimeter-scale device launched by...
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作者：Elrod, Susan
作者单位：Indiana University System; Indiana University South Bend
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作者：Elves-Powell, Joshua; Axmacher, Jan C.; Linnell, John D. C.; Durant, Sarah M.
作者单位：Zoological Society of London; University of London; University College London; Norwegian Institute Nature Research
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作者：Moayedi, Massieh; Atlas, Lauren Y.
作者单位：University of Toronto; University of Toronto; Krembil Research Institute; University of Toronto; University Health Network Toronto; National Institutes of Health (NIH) - USA; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH); National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); NIH National Institute on Aging (NIA)
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作者：Liang, Yinwen; Koche, Richard; Chalamalasetty, Ravindra B.; Stephen, Daniel N.; Kennedy, Mark W.; Lao, Zhimin; Pang, Yunong; Kuo, Ying-Yi; Lee, Moonsup; Lobo, Francisco Pereira; Huang, Xiaofeng; Hadjantonakis, Anna-Katerina; Yamaguchi, Terry P.; Anderson, Kathryn V.; Joyner, Alexandra L.
作者单位：Memorial Sloan Kettering Cancer Center; Memorial Sloan Kettering Cancer Center; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Cornell University
摘要：Although specific transcription factors (TFs) are known to regulate cell fate decisions, the degree to which they can stimulate formation of specific cell organelles is less clear. We used a multiomics comparison of the transcriptomes of ciliated and unciliated embryonic cells to identify TFs up-regulated in ciliated cells. We also used conditional genetics in mouse embryos and stem cells and found that the TFs SP5 and SP8 regulate cilia formation and gene expression. In embryos lacking Sp5 an...
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作者：Charalambous, Constantinos; Pike, W. Thomas; Kim, Doyeon; Samuel, Henri; Fernando, Benjamin; Bill, Carys; Lognonne, Philippe; Banerdt, W. Bruce
作者单位：Imperial College London; Imperial College London; Centre National de la Recherche Scientifique (CNRS); Universite Paris Cite; Johns Hopkins University; University of Oxford; University of Oxford; California Institute of Technology; National Aeronautics & Space Administration (NASA); NASA Jet Propulsion Laboratory (JPL)
摘要：A planet's interior is a time capsule, preserving clues to its early history. We report the discovery of kilometer-scale heterogeneities throughout Mars' mantle, detected seismically through pronounced wavefront distortion of energy arriving from deeply probing marsquakes. These heterogeneities, likely remnants of the planet's formation, imply a mantle that has undergone limited mixing driven by sluggish convection. Their size and survival constrain Mars' poorly known mantle rheology, indicati...
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作者：Grabarczyk, Daniel B.; Ehrmann, Julian F.; Murphy, Paul; Yang, Woo Seok; Kurzbauer, Robert; Bell, Lillie E.; Deszcz, Luiza; Neuhold, Jana; Schleiffer, Alexander; Shulkina, Alexandra; Lee, Juyeon; Shin, Jin Seok; Meinhart, Anton; Versteeg, Gijs A.; Zavodszky, Eszter; Song, Hyun Kyu; Hegde, Ramanujan S.; Clausen, Tim
作者单位：Vienna Biocenter (VBC); Research Institute of Molecular Pathology (IMP); University of Vienna; Medical University of Vienna; Vienna Biocenter (VBC); Medical University of Vienna; Vienna Biocenter (VBC); Korea University; Vienna Biocenter (VBC); University of Vienna; MRC Laboratory Molecular Biology; Medical University of Vienna; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital
摘要：Eukaryotic cells have evolved sophisticated quality control mechanisms to eliminate aggregation-prone proteins that compromise cellular health. Central to this defense is the ubiquitin-proteasome system, where UBR4 acts as an essential E4 ubiquitin ligase, amplifying degradation marks on defective proteins. Cryo-electron microscopy analysis of UBR4 in complex with its cofactors KCMF1 and CALM1 reveals a massive 1.3-megadalton ring structure, featuring a central substrate-binding arena and flex...
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作者：Huang, Ru-Jin; Li, Yong Jie; Chen, Qi; Zhang, Yanli; Lin, Chunshui; Chan, Chak K.; Yu, Jian Zhen; de Gouw, Joost; Tong, Shengrui; Jiang, Jingkun; Wang, Weigang; Ding, Xiang; Wang, Xinming; Ge, Maofa; Zhou, Weijian; Worsnop, Doug; Boy, Michael; Bilde, Merete; Dusek, Ulrike; Carlton, Annmarie G.; Hoffmann, Thorsten; McNeill, V. Faye; Glasius, Marianne
作者单位：Chinese Academy of Sciences; Institute of Earth Environment, CAS; Xi'an Jiaotong University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; University of Macau; University of Macau; Peking University; Chinese Academy of Sciences; Guangzhou Institute of Geochemistry, CAS; Chinese Academy of Sciences; Guangzhou Institute of Geochemistry, CAS; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; King Abdullah University of Science & Technology; University of Colorado System; University of Colorado Boulder; Chinese Academy of Sciences; Nanjing Institute of Geology & Paleontology, CAS; Institute of Chemistry, CAS; Tsinghua University; Aerodyne Research; University of Helsinki; Lappeenranta-Lahti University of Technology LUT; Aarhus University; University of Groningen; University of California System; University of California Irvine; Johannes Gutenberg University of Mainz; Columbia University; Columbia University
摘要：In the past decades, China has witnessed high air pollution associated with rapid economic development, although regulatory efforts have alleviated the situation since 2013. Haze events characterized by high particulate matter (PM) levels in China are not only of enormous magnitude but also represent a distinct chemical regime. Once driven by direct emissions, these high-PM episodes are now more affected by secondary aerosol, especially secondary organic aerosol (SOA). This Review synthesizes ...
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作者：Huff, Kathryn
作者单位：University of Illinois System; University of Illinois Urbana-Champaign
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作者：Rico, Benjamin; Barsanti, Kelley C.; Porter, William C.; Cysneiros de Carvalho, Karolina; Stigler-Granados, Paula; Prather, Kimberly A.
作者单位：University of California System; University of California San Diego; University of California System; University of California Riverside; California State University System; San Diego State University; University of California System; University of California San Diego; Scripps Institution of Oceanography
摘要：Industrial chemicals and untreated sewage have polluted the Tijuana River for decades, recently causing >1300 consecutive days of California beach closures. In summer 2024, wastewater flows surged to millions of gallons per day despite no rain, enhancing water-to-air transfer of hydrogen sulfide (H2S) and other toxic gases at a turbulent hotspot. High wastewater flows and low winds led to nighttime H2S peaks, reaching 4500 parts per billion (ppb)-exceeding typical urban levels of <1 ppb. H2S l...
