6763期

最新文章

• Somatotopic organization of brainstem analgesic circuitry AI翻译
  作者：Crawford, Lewis S.; Mendoza, Fernando A. Tinoco; Robertson, Rebecca V.; Meylakh, Noemi; Macey, Paul M.; Bannister, Kirsty; Wager, Tor D.; Macefield, Vaughan G.; Keay, Kevin A.; Henderson, Luke A.
  作者单位：University of Sydney; University of Sydney; University of California System; University of California Los Angeles; Imperial College London; Dartmouth College; Monash University
  摘要：The lateral periaqueductal gray (lPAG) evokes somatotopically appropriate defensive behaviors, including an analgesia that allows the animal to escape or fight unimpeded. Whether the lPAG and its descending targets are also able to drive somatotopically specific analgesic responses is not known. In this work, we performed ultrahigh-field functional magnetic resonance imaging of the lPAG in 93 participants during a placebo analgesia paradigm performed at different body locations. We found that ...
• Europe's biggest quake may foretell Atlantic 'ring of fire' AI翻译
  作者：Howell, Evan
• Yellowstone's free-moving large bison herds provide a glimpse of their past ecosystem function AI翻译
  作者：Geremia, Chris; Hamilton, E. William; Merkle, Jerod A.
  作者单位：United States Department of the Interior; US National Park Service; Washington & Lee University; University of Wyoming
  摘要：Although momentum is building to restore bison across North America, most efforts focus on small, managed herds, leaving unclear how large, migrating herds shape landscapes and whether their effects enhance or degrade ecosystems. We assessed carbon and nitrogen dynamics across the northern Yellowstone ecosystem, where one of the last remaining large migratory populations resides. Bison stabilized net aboveground production while accelerating nitrogen turnover, increasing aboveground nitrogen p...
• Bones beneath the runway AI翻译
  作者：Ortega, Rodrigo Perez
• Taking nuclear energy to the Moon AI翻译
  作者：Huff, Kathryn
  作者单位：University of Illinois System; University of Illinois Urbana-Champaign
• Heavily polluted Tijuana River drives regional air quality crisis AI翻译
  作者：Rico, Benjamin; Barsanti, Kelley C.; Porter, William C.; Cysneiros de Carvalho, Karolina; Stigler-Granados, Paula; Prather, Kimberly A.
  作者单位：University of California System; University of California San Diego; University of California System; University of California Riverside; California State University System; San Diego State University; University of California System; University of California San Diego; Scripps Institution of Oceanography
  摘要：Industrial chemicals and untreated sewage have polluted the Tijuana River for decades, recently causing >1300 consecutive days of California beach closures. In summer 2024, wastewater flows surged to millions of gallons per day despite no rain, enhancing water-to-air transfer of hydrogen sulfide (H2S) and other toxic gases at a turbulent hotspot. High wastewater flows and low winds led to nighttime H2S peaks, reaching 4500 parts per billion (ppb)-exceeding typical urban levels of <1 ppb. H2S l...
• Machine learning-based penetrance of genetic variants AI翻译
  作者：Forrest, Iain S.; Vy, Ha My T.; Rocheleau, Ghislain; Jordan, Daniel M.; Petrazzini, Ben O.; Nadkarni, Girish N.; Cho, Judy H.; Ganapathi, Mythily; Huang, Kuan-Lin; Chung, Wendy K.; Do, Ron
  作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Columbia University; Cornell University; Weill Cornell Medicine; NewYork-Presbyterian Hospital; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Boston Children's Hospital
  摘要：Accurate variant penetrance estimation is crucial for precision medicine. We constructed machine learning (ML) models for 10 diseases using 1,347,298 participants with electronic health records, then applied them to an independent cohort with linked exome data. Resulting probabilities were used to evaluate ML penetrance of 1648 rare variants in 31 autosomal dominant disease-predisposition genes. ML penetrance was variable across variant classes, but highest for pathogenic and loss-of-function ...
• AI hypotheses lag human ones when put to the test AI翻译
  作者：Brainard, Jeffrey
• Supply-chain vulnerabilities in critical medicines: A persistent risk to pharmaceutical security AI翻译
  作者：Casiraghi, Giona; Andres, Georges; Schweitzer, Frank; Verginer, Luca
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
• Sustainable personal cooling in a warming world AI翻译
  作者：Shou, Dahua; Li, Ziqi
  作者单位：Hong Kong Polytechnic University