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作者：Shenoy, Meera K.; Rico, Diane M.; Lorant, Alina K.; Toure, Hamadoun; Gordon, Shannon; Milburn, Luke J.; Schwensen, Jeanette S.; Caban, Madelyn E.; Koch, Meghan A.
作者单位：Fred Hutchinson Cancer Center; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN); Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Maternal antibodies fundamentally regulate gut immunity in the developing infant, yet the mechanisms underlying this process remain elusive. We found that maternal immunoglobulin G (IgG), ingested in the first week of life, restrained microbiota-dependent adaptive immune responses weeks later, after weaning. This activity was linked to maternal antibodies that could bind bacteria in the neonatal gut and the ability of microbe-IgG complexes to engage Fc and complement-dependent effector functio...
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作者：Spears, Brian K.; Brandon, Scott; Casey, Dan T.; Field, John E.; Gaffney, Jim A.; Humbird, Kelli D.; Kritcher, Andrea L.; Kruse, Michael K. G.; Kur, Eugene; Kustowski, Bogdan; Langer, S.; Munro, Dave; Nora, Ryan; Peterson, J. Luc; Schlossberg, Dave J.; Springer, Paul; Zylstra, Alex
作者单位：United States Department of Energy (DOE); Lawrence Livermore National Laboratory
摘要：An inertial confinement fusion experiment, carried out at the National Ignition Facility, has achieved ignition by generating fusion energy exceeding the laser energy that drove the experiment. Prior to the experiment, a generative machine learning model that combines radiation hydrodynamics simulations, deep learning, experimental data, and Bayesian statistics was used to predict, with a probability greater than 70%, that ignition was the most likely outcome for this shot.
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作者：Suomalainen, Anu; Nikkanen, Joni
作者单位：University of Helsinki; University of Helsinki; University of Helsinki; Helsinki University Central Hospital; University of California System; University of California Berkeley
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作者：Cutts, Elise
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作者：Holst, Bodil
作者单位：University of Bergen
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作者：Xie, Yonglong; Pierce, Andrew T.; Park, Jeong Min; Parker, Daniel E.; Wang, Jie; Ledwith, Patrick; Cai, Zhuozhen; Watanabe, Kenji; Taniguchi, Takashi; Khalaf, Eslam; Vishwanath, Ashvin; Jarillo-Herrero, Pablo; Yacoby, Amir
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Rice University; Rice University; Harvard University; National Institute for Materials Science; National Institute for Materials Science
摘要：In multilayer moir & eacute; heterostructures, the interference of multiple twist angles ubiquitously leads to tunable ultralong-wavelength patterns known as supermoir & eacute; lattices. However, their impact on the system's many-body electronic phase diagram remains largely unexplored. We present local compressibility measurements revealing numerous incompressible states resulting from supermoir & eacute; lattice-scale isospin symmetry breaking driven by strong interactions. By using the sup...
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作者：Vaitiekenas, S.
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作者：Goldman, Gretchen; Chenoweth, Erica
作者单位：Harvard University
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作者：Gropp, Jonathan; Bill, Markus; Lloyd, Max K.; Stein, Rebekah A.; Nayak, Dipti D.; Stolper, Daniel A.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; University of California System; University of California Berkeley
摘要：The stable isotopic composition of microbial methane varies substantially, and the underlying causes are debated. In this work, we experimentally controlled the abundance of the central enzyme in methanogenesis, methyl-coenzyme M reductase (MCR), in Methanosarcina acetivorans and tested whether its cellular concentration alters methane isotopic compositions. We found that during growth on methanol and acetate, lowering the expression of mcr increases the degree of hydrogen isotope exchange bet...
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作者：Shen, Xuzhong; Chen, Xiahe; Xiao, Yihang; Brown, Jesse B.; Zhang, James G.; Ji, Xinyuan; Rui, Jinyan; Garcia-Borras, Marc; Rao, Yi; Yang, Yunfang; Huang, Xiongyi
作者单位：Johns Hopkins University; Zhejiang University of Technology; Utah System of Higher Education; Utah State University; Universitat de Girona; Universitat de Girona
摘要：Copper-catalyzed radical C(sp3)-N coupling has become a major focus in synthetic catalysis over the past decade. However, achieving this reaction manifold by using enzymes has remained elusive. In this study, we introduce a photobiocatalytic approach for radical benzylic C(sp3)-N coupling using a copper-substituted nonheme enzyme. Using rhodamine B as a photoredox catalyst, we identified a copper-substituted phenylalanine hydroxylase that facilitates enantioconvergent decarboxylative amination...
