2025

最新文章

• Lessons from Lebanon AI翻译
  作者：Kfoury, Peter
  作者单位：Utah System of Higher Education; University of Utah
• Evolution of interorganismal strigolactone biosynthesis in seed plants AI翻译
  作者：Zhou, Anqi; Kane, Annalise; Wu, Sheng; Wang, Kaibiao; Santiago, Michell; Ishiguro, Yui; Yoneyama, Kaori; Palayam, Malathy; Shabek, Nitzan; Xie, Xiaonan; Nelson, David C.; Li, Yanran
  作者单位：University of California System; University of California San Diego; University of California System; University of California Riverside; Shanghai University of Traditional Chinese Medicine; Utsunomiya University; Saitama University; University of California System; University of California Davis
  摘要：Strigolactones (SLs) are methylbutenolide molecules derived from beta-carotene through an intermediate carlactonoic acid (CLA). Canonical SLs act as signals to microbes and plants, whereas noncanonical SLs are primarily plant hormones. The cytochrome P450 CYP722C catalyzes a critical step, converting CLA to canonical SLs in most angiosperms. Using synthetic biology, we investigated the function of CYP722A, an evolutionary predecessor of CYP722C. CYP722A converts CLA into 16-hydroxy-CLA (16-OH-...
• Physicians urge redefining obesity AI翻译
  作者：Brainard, Jeffrey
• German universities flee X AI翻译
  作者：Brainard, Jeffrey
• ASTRONOMY Energy megaproject threatens giant telescopes AI翻译
  作者：Clery, Daniel
• Stereomicrostructure-regulated biodegradable adhesives AI翻译
  作者：Zhang, Zhen; Quinn, Ethan C.; Kenny, Jacob K.; Grigoropoulos, Alexandra; DesVeaux, Jason S.; Chen, Tiffany; Zhou, Li; Xu, Ting; Beckham, Gregg T.; Chen, Eugene Y. -X.
  作者单位：Colorado State University System; Colorado State University Fort Collins; United States Department of Energy (DOE); National Renewable Energy Laboratory - USA; University of California System; University of California Berkeley; University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; South China University of Technology
  摘要：Commercial adhesives are petroleum-based thermoset networks or nonbiodegradable thermoplastic hot melts, making them ideal targets for replacement by biodegradable alternatives. Poly(3-hydroxybutyrate) (P3HB) is a biorenewable and biodegradable alternative to conventional plastics, but microbial P3HB, which has a stereoperfect stereomicrostructure, exhibits no adhesion. In this study, by elucidating the fundamental relationship between chemocatalytically engineered P3HB stereomicrostructures a...
• Mechanically interlocked two-dimensional polymers AI翻译
  作者：Bardot, Madison I.; Weyhrich, Cody W.; Shi, Zixiao; Traxler, Michael; Stern, Charlotte L.; Cui, Jinlei; Muller, David A.; Becker, Matthew L.; Dichtel, William R.
  作者单位：Northwestern University; Duke University; Cornell University; Cornell University; Cornell University; Duke University; Duke University
  摘要：Mechanical bonds arise between molecules that contain interlocked subunits, such as one macrocycle threaded through another. Within polymers, these linkages will confer distinctive mechanical properties and other emergent behaviors, but polymerizations that form mechanical bonds efficiently and use simple monomeric building blocks are rare. In this work, we introduce a solid-state polymerization in which one monomer infiltrates crystals of another to form a macrocycle and mechanical bond at ea...
• Identity politics is economic policy AI翻译
  作者：Pande, Rohini
  作者单位：Yale University
• 3D polycatenated architected materials AI翻译
  作者：Zhou, Wenjie; Nadarajah, Sujeeka; Li, Liuchi; Izard, Anna Guell; Yan, Hujie; Prachet, Aashutosh K.; Patel, Payal; Xia, Xiaoxing; Daraio, Chiara
  作者单位：California Institute of Technology; Princeton University; Johns Hopkins University; United States Department of Energy (DOE); Lawrence Livermore National Laboratory
  摘要：Architected materials derive their properties from the geometric arrangement of their internal structural elements. Their designs rely on continuous networks of members to control the global mechanical behavior of the bulk. In this study, we introduce a class of materials that consist of discrete concatenated rings or cage particles interlocked in three-dimensional networks, forming polycatenated architected materials (PAMs). We propose a general design framework that translates arbitrary crys...
• Neuronal-ILC2 interactions regulate pancreatic glucagon and glucose homeostasis AI翻译
  作者：Sestan, Marko -; Raposo, Bruno; Rendas, Miguel; Brea, David; Pirzgalska, Roksana; Rasteiro, Ana; Aliseychik, Maria; Godinho, Ines; Ribeiro, Helder; Carvalho, Tania; Wueest, Stephan; Konrad, Daniel; Veiga-Fernandes, Henrique
  作者单位：University of Rijeka; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Investigaciones Biomedicas de Barcelona (IIBB); University of Zurich; University Children's Hospital Zurich; University Children's Hospital Zurich; University of Zurich; University of Zurich; Zurich Center Integrative Human Physiology (ZIHP)
  摘要：The immune system shapes body metabolism, while interactions between peripheral neurons and immune cells control tissue homeostasis and immunity. However, whether peripheral neuroimmune interactions orchestrate endocrine system functions remains unexplored. After fasting, mice lacking type 2 innate lymphoid cells (ILC2s) displayed disrupted glucose homeostasis, impaired pancreatic glucagon secretion, and inefficient hepatic gluconeogenesis. Additionally, intestinal ILC2s were found in the panc...