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作者：Arman, Samuel D.; Gully, Grant A.; Prideaux, Gavin J.
作者单位：Flinders University South Australia
摘要：Identifying what drove the late Pleistocene megafaunal extinctions on the continents remains one of the most contested topics in historical science. This is especially so in Australia, which lost 90% of its large species by 40,000 years ago, more than half of them kangaroos. Determining causation has been obstructed by a poor understanding of their ecology. Using dental microwear texture analysis, we show that most members of Australia's richest Pleistocene kangaroo assemblage had diets that w...
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作者：Goessling, Wolfram
作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School
摘要：Bile acids differentially affect immune cell responses to liver cancer
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作者：Ren, Yi; Ma, Hui; Kim, Jinsu; Al Otmi, Mohammed; Lin, Ping; Dai, Changhui; Lee, Young Joo; Zhai, Zihan; Jang, Woo Jin; Yang, Shijie; Sarswat, Akriti; Feliachi, Yacine; Sampath, Janani; Realff, Matthew J.; Lively, Ryan P.; Guo, Sheng
作者单位：University System of Georgia; Georgia Institute of Technology; Nanjing University; Chonnam National University; State University System of Florida; University of Florida; State University System of Florida; University of Florida
摘要：We explored the potential for membrane materials to reduce energy and carbon requirements for the separation of aliphatic hydrocarbon feedstocks and products. We developed a series of fluorine-rich poly(arylene amine) polymer membranes that feature rigid polymer backbones with segregated perfluoroalkyl side chains. This combination imbues the polymers with resistance to dilation induced by hydrocarbon immersion without the loss of solution-based membrane fabrication techniques. These materials...
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作者：Brainard, Jeffrey
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作者：Brainard, Jeffrey
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作者：Lanzarini, Francesca; Maranesi, Monica; Rondoni, Elena Hilary; Albertini, Davide; Ferretti, Elena; Lanzilotto, Marco; Micera, Silvestro; Mazzoni, Alberto; Bonini, Luca
作者单位：University of Parma; Scuola Superiore Sant'Anna; Scuola Superiore Sant'Anna; Scuola Superiore Sant'Anna; Vita-Salute San Raffaele University; Scuola Superiore Sant'Anna; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要：The current understanding of primate natural action organization derives from laboratory experiments in restrained contexts (RCs) under the assumption that this knowledge generalizes to freely moving contexts (FMCs). In this work, we developed a neurobehavioral platform to enable wireless recording of the same premotor neurons in both RCs and FMCs. Neurons often encoded the same hand and mouth actions differently in RCs and FMCs. Furthermore, in FMCs, we identified cells that selectively encod...
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作者：Bistline, John; Bergman, Aaron; Blanford, Geoffrey; Brown, Maxwell; Burtraw, Dallas; Domeshek, Maya; Fawcett, Allen; Hamilton, Anne; Iyer, Gokul; Jenkins, Jesse; King, Ben; Kolus, Hannah; Levin, Amanda; Luo, Qian; Rennert, Kevin; Robertson, Molly; Roy, Nicholas; Russell, Ethan; Shawhan, Daniel; Steinberg, Daniel; van Brummen, Anna; Van Horn, Grace; Venkatesh, Aranya; Weyant, John; Wiser, Ryan; Zhao, Alicia
作者单位：Electric Power Research Institute (EPRI); Resources for the Future; Colorado School of Mines; University System of Maryland; University of Maryland College Park; United States Department of Energy (DOE); National Renewable Energy Laboratory - USA; Princeton University; Stanford University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
摘要：Emissions reductions may be met with relatively small costs
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作者：Kaiser, Jocelyn
摘要：But so far, few investigators seem interested in having their work repeated
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作者：Varanasi, Siva Karthik; Chen, Dan; Liu, Yingluo; Johnson, Melissa A.; Miller, Cayla M.; Ganguly, Souradipta; Lande, Kathryn; LaPorta, Michael A.; Hoffmann, Filipe Araujo; Mann, Thomas H.; Teneche, Marcos G.; Casillas, Eduardo; Mangalhara, Kailash C.; Mathew, Varsha; Sun, Ming; Jensen, Isaac J.; Farsakoglu, Yagmur; Chen, Timothy; Parisi, Bianca; Deota, Shaunak; Havas, Aaron; Lee, Jin; Chung, H. Kay; Schietinger, Andrea; Panda, Satchidananda; Williams, April E.; Farber, Donna L.; Dhar, Debanjan; Adams, Peter D.; Feng, Gen-Sheng; Shadel, Gerald S.; Sundrud, Mark S.; Kaech, Susan M.
作者单位：Salk Institute; University of California System; University of California San Diego; Sanford Burnham Prebys Medical Discovery Institute; University of California System; University of California San Diego; Salk Institute; Columbia University; NewYork-Presbyterian Hospital; Columbia University; NewYork-Presbyterian Hospital; Salk Institute; Memorial Sloan Kettering Cancer Center; Cornell University; Dartmouth College; Dartmouth College; University of Massachusetts System; University of Massachusetts Worcester
摘要：The metabolic landscape of cancer greatly influences antitumor immunity, yet it remains unclear how organ-specific metabolites in the tumor microenvironment influence immunosurveillance. We found that accumulation of primary conjugated and secondary bile acids (BAs) are metabolic features of human hepatocellular carcinoma and experimental liver cancer models. Inhibiting conjugated BA synthesis in hepatocytes through deletion of the BA-conjugating enzyme bile acid-CoA:amino acid N-acyltransfera...
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作者：Leslie, Mitch
摘要：The first clinical trial of zebrafish embryos acting as cancer avatars will start soon
