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作者：Shioi, Takuro; Hatazawa, Suguru; Oya, Eriko; Hosoya, Noriko; Kobayashi, Wataru; Ogasawara, Mitsuo; Kobayashi, Takehiko; Takizawa, Yoshimasa; Kurumizaka, Hitoshi
作者单位：University of Tokyo; University of Tokyo; University of Tokyo; University of Tokyo
摘要：RAD51 is the central eukaryotic recombinase required for meiotic recombination and mitotic repair of double-strand DNA breaks (DSBs)(1,2). However, the mechanism by which RAD51 functions at DSB sites in chromatin has remained elusive. Here we report the cryo-electron microscopy structures of human RAD51-nucleosome complexes, in which RAD51 forms ring and filament conformations. In the ring forms, the N-terminal lobe domains (NLDs) of RAD51 protomers are aligned on the outside of the RAD51 ring...
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作者：Han, Guangchun; Sinjab, Ansam; Rahal, Zahraa; Lynch, Anne M.; Treekitkarnmongkol, Warapen; Liu, Yuejiang; Serrano, Alejandra G.; Feng, Jiping; Liang, Ke; Khan, Khaja; Lu, Wei; Hernandez, Sharia D.; Liu, Yunhe; Cao, Xuanye; Dai, Enyu; Pei, Guangsheng; Hu, Jian; Abaya, Camille; Gomez-Bolanos, Lorena I.; Peng, Fuduan; Chen, Minyue; Parra, Edwin R.; Cascone, Tina; Sepesi, Boris; Moghaddam, Seyed Javad; Scheet, Paul; Negrao, Marcelo V.; Heymach, John V.; Li, Mingyao; Dubinett, Steven M.; Stevenson, Christopher S.; Spira, Avrum E.; Fujimoto, Junya; Solis, Luisa M.; Wistuba, Ignacio I.; Chen, Jichao; Wang, Linghua; Kadara, Humam
作者单位：University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; Baylor College of Medicine; University of Pennsylvania; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of Texas System; UTMD Anderson Cancer Center; University of California System; University of California Los Angeles; Johnson & Johnson; Johnson & Johnson USA; Boston University
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作者：Delgado-Ramos, Gian C.; Lucatello, Simone; Ley, Debora; Ivanova, Antonina; Romo-Aguilar, Ma de Lourdes; Conde, Cecilia; Imaz-Lamadrid, Miguel
作者单位：Universidad Nacional Autonoma de Mexico; Universidad Autonoma de Baja California; Universidad Autonoma de Baja California; Universidad Nacional Autonoma de Mexico; Universidad Autonoma de Baja California
摘要：Hurricane Otis yields lessons for researchers and policymakers on how to reduce risks in the face of inequality.
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作者：Mitchard, Edward; Ellis, Peter; Patton, Susan Cook; Adjei, Roselyn Fosuah
作者单位：Nature Conservancy
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作者：Konietzka, Ralf; Goodman, Alyssa A.; Zucker, Catherine; Burkert, Andreas; Alves, Joao; Foley, Michael; Swiggum, Cameren; Koller, Maria; Miret-Roig, Nuria
作者单位：Harvard University; Smithsonian Institution; University of Munich; Max Planck Society; Space Telescope Science Institute; University of Munich; University of Vienna
摘要：Our Sun lies within 300 parsecs of the 2.7-kiloparsecs-long sinusoidal chain of dense gas clouds known as the Radcliffe Wave1. The structure's wave-like shape was discovered using three-dimensional dust mapping, but initial kinematic searches for oscillatory motion were inconclusive2-7. Here we present evidence that the Radcliffe Wave is oscillating through the Galactic plane while also drifting radially away from the Galactic Centre. We use measurements of line-of-sight velocity8 for 12CO and...
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作者：Sonnert, Nicole D.; Rosen, Connor E.; Ghazi, Andrew R.; Franzosa, Eric A.; Duncan-Lowey, Brianna; Gonzalez-Hernandez, Jaime A.; Huck, John D.; Yang, Yi; Dai, Yile; Rice, Tyler A.; Mytien T. Nguyen; Song, Deguang; Cao, Yiyun; Martin, Anjelica L.; Bielecka, Agata A.; Fischer, Suzanne; Guan, Changhui; Oh, Julia; Huttenhower, Curtis; Ring, Aaron M.; Palm, Noah W.
作者单位：Yale University; Yale University; Harvard University; Harvard T.H. Chan School of Public Health; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Jackson Laboratory; Yale University
摘要：The myriad microorganisms that live in close association with humans have diverse effects on physiology, yet the molecular bases for these impacts remain mostly unknown(1-3). Classical pathogens often invade host tissues and modulate immune responses through interactions with human extracellular and secreted proteins (the 'exoproteome'). Commensal microorganisms may also facilitate niche colonization and shape host biology by engaging host exoproteins; however, direct exoproteome-microbiota in...
