-
作者：[Anonymous]
-
作者：Radko-Juettner, Sandi; Yue, Hong; Myers, Jacquelyn A.; Carter, Raymond D.; Robertson, Alexis N.; Mittal, Priya; Zhu, Zhexin; Hansen, Baranda S.; Donovan, Katherine A.; Hunkeler, Moritz; Rosikiewicz, Wojciech; Wu, Zhiping; Mcreynolds, Meghan G.; Roy Burman, Shourya S.; Schmoker, Anna M.; Mageed, Nada; Brown, Scott A.; Mobley, Robert J.; Partridge, Janet F.; Stewart, Elizabeth A.; Pruett-Miller, Shondra M.; Nabet, Behnam; Peng, Junmin; Gray, Nathanael S.; Fischer, Eric S.; Roberts, Charles W. M.
作者单位：St Jude Children's Research Hospital; St Jude Children's Research Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Fred Hutchinson Cancer Center; Stanford Cancer Institute
摘要：Whereas oncogenes can potentially be inhibited with small molecules, the loss of tumour suppressors is more common and is problematic because the tumour-suppressor proteins are no longer present to be targeted. Notable examples include SMARCB1-mutant cancers, which are highly lethal malignancies driven by the inactivation of a subunit of SWI/SNF (also known as BAF) chromatin-remodelling complexes. Here, to generate mechanistic insights into the consequences of SMARCB1 mutation and to identify ...
-
作者：Nogales, Eva; Mahamid, Julia
作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Howard Hughes Medical Institute; European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL)
摘要：Most life scientists would agree that understanding how cellular processes work requires structural knowledge about the macromolecules involved. For example, deciphering the double-helical nature of DNA revealed essential aspects of how genetic information is stored, copied and repaired. Yet, being reductionist in nature, structural biology requires the purification of large amounts of macromolecules, often trimmed off larger functional units. The advent of cryogenic electron microscopy (cryo-...
-
作者：Garisto, Dan
摘要：This 2D material is only the second to exhibit the fractional quantum anomalous Hall effect, and theorists are still debating how it works.
-
作者：Lenharo, Mariana
摘要：Lawsuit could roll back access to mifepristone, a drug widely used to induce abortion in the United States.
-
作者：Sidik, Saima May
-
作者：Pliota, Pinelopi; Marvanova, Hana; Koreshova, Alevtina; Kaufman, Yotam; Tikanova, Polina; Krogull, Daniel; Hagmueller, Andreas; Widen, Sonya A.; Handler, Dominik; Gokcezade, Joseph; Duchek, Peter; Brennecke, Julius; Ben-David, Eyal; Burga, Alejandro
作者单位：Vienna Biocenter (VBC); Institute of Molecular Biotechnology (IMBA); Medical University of Vienna; Vienna Biocenter (VBC); University of Vienna; Medical University of Vienna; Hebrew University of Jerusalem; Illumina
摘要：Genomic imprinting-the non-equivalence of maternal and paternal genomes-is a critical process that has evolved independently in many plant and mammalian species1,2. According to kinship theory, imprinting is the inevitable consequence of conflictive selective forces acting on differentially expressed parental alleles3,4. Yet, how these epigenetic differences evolve in the first place is poorly understood3,5,6. Here we report the identification and molecular dissection of a parent-of-origin eff...
-
作者：Iliescu, Dragos; Greiff, Samuel
作者单位：University of Bucharest; Goethe University Frankfurt
-
作者：Sidik, Saima
摘要：Carrying a baby creates some of the same epigenetic patterns on DNA seen in older people.
-
作者：[Anonymous]
摘要：Copper-containing 'nanoclusters' form glasses with an orderly structure and unusual properties.
