作者：Crow, James Mitchell; Nitschke, Matthew
作者单位：Australian Institute of Marine Science; Victoria University Wellington
作者：Chan, Jack D.; Scheffler, Christina M.; Munoz, Isabelle; Sek, Kevin; Lee, Joel N.; Huang, Yu-Kuan; Yap, Kah Min; Saw, Nicole Y. L.; Li, Jasmine; Chen, Amanda X. Y.; Chan, Cheok Weng; Derrick, Emily B.; Todd, Kirsten L.; Tong, Junming; Dunbar, Phoebe A.; Li, Jiawen; Hoang, Thang X.; de Menezes, Maria N.; Petley, Emma V.; Kim, Joelle S.; Nguyen, Dat; Leung, Patrick S. K.; So, Joan; Deguit, Christian; Zhu, Joe; House, Imran G.; Kats, Lev M.; Scott, Andrew M.; Solomon, Benjamin J.; Harrison, Simon J.; Oliaro, Jane; Parish, Ian A.; Quinn, Kylie M.; Neeson, Paul J.; Slaney, Clare Y.; Lai, Junyun; Beavis, Paul A.; Darcy, Phillip K.
作者单位：Peter Maccallum Cancer Center; Peter Maccallum Cancer Center; University of Melbourne; Royal Melbourne Institute of Technology (RMIT); La Trobe University; Olivia Newton-John Cancer Research Institute; La Trobe University; University of Melbourne; Peter Maccallum Cancer Center; Melbourne Health; Royal Melbourne Hospital; Monash University; Monash University
摘要：Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of haematological malignancies such as acute lymphoblastic leukaemia, B cell lymphoma and multiple myeloma 1-4 , but the efficacy of CAR T cell therapy in solid tumours has been limited 5 . This is owing to a number of factors, including the immunosuppressive tumour microenvironment that gives rise to poorly persisting and metabolically dysfunctional T cells. Analysis of anti-CD19 CAR T cells used clinically has shown...
