8010期

最新文章

• Male-female comparisons are powerful in biomedical research - don't abandon them AI翻译
  作者：Arnold, Arthur P.; Klein, Sabra L.; McCarthy, Margaret M.; Mogil, Jeffrey S.
  作者单位：University of California System; University of California Los Angeles; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; McGill University; McGill University; McGill University
  摘要：Binary sex studies have been denounced as too simplistic, but dropping them altogether would impede progress in a long-neglected area of biomedicine.
• Galaxy found napping in the primordial Universe AI翻译
  作者：Antwi-Danso, Jacqueline
  作者单位：University of Toronto
  摘要：Observations have revealed a galaxy that stopped forming stars earlier than expected. This discovery offers clues about when the first galaxies emerged and sheds light on how stars formed when the Universe was in its infancy.
• Why doing science is difficult in India today AI翻译
  作者：Aiyar, Yamini
  摘要：With an election under way, the future of Indian science is on the ballot. Encouraging research and critical thinking should be a priority for the new government.
• Shrouded in secrecy: how science is harmed by the bullying and harassment rumour mill AI翻译
  作者：Wild, Sarah
  摘要：Academics are calling for greater transparency in harassment cases. But do the benefits outweigh the risks?
• Canadian science gets biggest boost to PhD and postdoc pay in 20 years AI翻译
  作者：Owens, Brian
  摘要：Government budget includes more money for basic research and notable increases to postgraduate stipends.
• Magnetic field effects on behaviour in Drosophila AI翻译
  作者：Reppert, Steven M.
  作者单位：University of Massachusetts System; UMass Chan Medical School; University of Massachusetts Worcester
• Air-travel climate-change emissions detailed for nearly 200 nations AI翻译
  作者：[Anonymous]
  摘要：Carbon emissions from flights that departed from low- and middle-income countries in 2019 totalled 417 million tonnes.
• Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase AI翻译
  作者：Baltgalvis, Kristen A.; Lamb, Kelsey N.; Symons, Kent T.; Wu, Chu-Chiao; Hoffman, Melissa A.; Snead, Aaron N.; Song, Xiaodan; Glaza, Thomas; Kikuchi, Shota; Green, Jason C.; Rogness, Donald C.; Lam, Betty; Rodriguez-Aguirre, Maria E.; Woody, David R.; Eissler, Christie L.; Rodiles, Socorro; Negron, Seth M.; Bernard, Steffen M.; Tran, Eileen; Pollock, Jonathan; Tabatabaei, Ali; Contreras, Victor; Williams, Heather N.; Pastuszka, Martha K.; Sigler, John J.; Pettazzoni, Piergiorgio; Rudolph, Markus G.; Classen, Moritz; Brugger, Doris; Claiborne, Christopher; Plancher, Jean-Marc; Cuartas, Isabel; Seoane, Joan; Burgess, Laurence E.; Abraham, Robert T.; Weinstein, David S.; Simon, Gabriel M.; Patricelli, Matthew P.; Kinsella, Todd M.
  作者单位：Hospital Universitari Vall d'Hebron; Autonomous University of Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; Vall d'Hebron Institut d'Oncologia (VHIO)
  摘要：WRN helicase is a promising target for treatment of cancers with microsatellite instability (MSI) due to its essential role in resolving deleterious non-canonical DNA structures that accumulate in cells with faulty mismatch repair mechanisms1-5. Currently there are no approved drugs directly targeting human DNA or RNA helicases, in part owing to the challenging nature of developing potent and selective compounds to this class of proteins. Here we describe the chemoproteomics-enabled discovery ...
• 'Shut up and calculate': how Einstein lost the battle to explain quantum reality AI翻译
  作者：Baggott, Jim
  摘要：By suppressing questions they considered too 'philosophical', post-war physicists created an unquestioning orthodoxy that influences science to this day.
• Metabolic rewiring promotes anti-inflammatory effects of glucocorticoids AI翻译
  作者：Auger, Jean-Philippe; Zimmermann, Max; Faas, Maria; Stifel, Ulrich; Chambers, David; Krishnacoumar, Brenda; Taudte, R. Verena; Grund, Charlotte; Erdmann, Gitta; Scholtysek, Carina; Uderhardt, Stefan; Ben Brahim, Oumaima; Mate, Monica Pascual; Stoll, Cornelia; Boettcher, Martin; Palumbo-Zerr, Katrin; Mangan, Matthew S. J.; Dzamukova, Maria; Kieler, Markus; Hofmann, Melanie; Blueml, Stephan; Schabbauer, Gernot; Mougiakakos, Dimitrios; Sonnewald, Uwe; Hartmann, Fabian; Simon, David; Kleyer, Arnd; Grueneboom, Anika; Finotto, Susetta; Latz, Eicke; Hofmann, Joerg; Schett, Georg; Tuckermann, Jan; Kroenke, Gerhard
  作者单位：University of Erlangen Nuremberg; University of Erlangen Nuremberg; University of Erlangen Nuremberg; Ulm University; Dortmund University of Technology; Leibniz Association; Leibniz Institut fur Analytische Wissenschaften (ISAS); University of Duisburg Essen; University of Erlangen Nuremberg; Philipps University Marburg; Helmholtz Association; German Cancer Research Center (DKFZ); University of Erlangen Nuremberg; Otto von Guericke University; University of Bonn; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Medical University of Vienna; Medical University of Vienna; University of Erlangen Nuremberg; University of Erlangen Nuremberg; Leibniz Association; Deutsches Rheuma-Forschungszentrum (DRFZ)
  摘要：Glucocorticoids represent the mainstay of therapy for a broad spectrum of immune-mediated inflammatory diseases. However, the molecular mechanisms underlying their anti-inflammatory mode of action have remained incompletely understood(1). Here we show that the anti-inflammatory properties of glucocorticoids involve reprogramming of the mitochondrial metabolism of macrophages, resulting in increased and sustained production of the anti-inflammatory metabolite itaconate and consequent inhibition...