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作者：Cook, Tyler M.; Sandoval, Darleen
作者单位：University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado System; University of Colorado Anschutz Medical Campus; University of Colorado System; University of Colorado Anschutz Medical Campus
摘要：A two-in-one drug that modulates neural pathways involved in appetite and reward might prove to be more effective and longer lasting than current weight-loss drugs on the market.
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作者：Nogrady, Bianca
摘要：Genomic analysis suggests the common kitchen vermin spread from Europe to the world. But it wasn't originally found in Europe.
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作者：Nuwer, Rachel
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作者：Woolston, Chris
摘要：Recruitment challenges and limited resources are among the challenges faced by scientists who live and work off the beaten track.
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作者：Yang, Zheyu; Wang, Taoyi; Lin, Yihan; Chen, Yuguo; Zeng, Hui; Pei, Jing; Wang, Jiazheng; Liu, Xue; Zhou, Yichun; Zhang, Jianqiang; Wang, Xin; Lv, Xinhao; Zhao, Rong; Shi, Luping
作者单位：Tsinghua University; Tsinghua University; Tsinghua University; Tsinghua University
摘要：Image sensors face substantial challenges when dealing with dynamic, diverse and unpredictable scenes in open-world applications. However, the development of image sensors towards high speed, high resolution, large dynamic range and high precision is limited by power and bandwidth. Here we present a complementary sensing paradigm inspired by the human visual system that involves parsing visual information into primitive-based representations and assembling these primitives to form two compleme...
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作者：Bellafard, Arash; Namvar, Ghazal; Kao, Jonathan C.; Vaziri, Alipasha; Golshani, Peyman
作者单位：University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; Rockefeller University; Rockefeller University; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：Working memory, the process through which information is transiently maintained and manipulated over a brief period, is essential for most cognitive functions(1-4). However, the mechanisms underlying the generation and evolution of working-memory neuronal representations at the population level over long timescales remain unclear. Here, to identify these mechanisms, we trained head-fixed mice to perform an olfactory delayed-association task in which the mice made decisions depending on the seq...
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作者：Niepoth, Natalie; Merritt, Jennifer R.; Uminski, Michelle; Lei, Emily; Esquibies, Victoria S.; Bando, Ina B.; Hernandez, Kimberly; Gebhardt, Christoph; Wacker, Sarah A.; Lutzu, Stefano; Poudel, Asmita; Soma, Kiran K.; Rudolph, Stephanie; Bendesky, Andres
作者单位：Columbia University; Columbia University; Manhattan University; Yeshiva University; Yeshiva University; University of British Columbia; University of British Columbia
摘要：Cell types with specialized functions fundamentally regulate animal behaviour, and yet the genetic mechanisms that underlie the emergence of novel cell types and their consequences for behaviour are not well understood1. Here we show that the monogamous oldfield mouse (Peromyscus polionotus) has recently evolved a novel cell type in the adrenal gland that expresses the enzyme AKR1C18, which converts progesterone into 20 alpha-hydroxyprogesterone. We then demonstrate that 20 alpha-hydroxyproges...
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作者：Petersen, Jonas; Ludwig, Mette Q.; Juozaityte, Vaida; Ranea-Robles, Pablo; Svendsen, Charlotte; Hwang, Eunsang; Kristensen, Amalie W.; Fadahunsi, Nicole; Lund, Jens; Breum, Alberte W.; Mathiesen, Cecilie V.; Sachs, Luisa; Moreno-Justicia, Roger; Rohlfs, Rebecca; Ford, James C.; Douros, Jonathan D.; Finan, Brian; Portillo, Bryan; Grose, Kyle; Petersen, Jacob E.; Trauelsen, Mette; Feuchtinger, Annette; DiMarchi, Richard D.; Schwartz, Thue W.; Deshmukh, Atul S.; Thomsen, Morten B.; Kohlmeier, Kristi A.; Williams, Kevin W.; Pers, Tune H.; Frlound, Bente; Stromgaard, Kristian; Klein, Anders B.; Clemmensen, Christoffer
作者单位：Novo Nordisk Foundation; University of Copenhagen; University of Copenhagen; University of Texas System; University of Texas Southwestern Medical Center; Indiana University System; Indiana University Bloomington; University of Copenhagen
摘要：The N-methyl-D-aspartate (NMDA) receptor is a glutamate-activated cation channel that is critical to many processes in the brain. Genome-wide association studies suggest that glutamatergic neurotransmission and NMDA receptor-mediated synaptic plasticity are important for body weight homeostasis(1). Here we report the engineering and preclinical development of a bimodal molecule that integrates NMDA receptor antagonism with glucagon-like peptide-1 (GLP-1) receptor agonism to effectively reverse...
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作者：Dirnberger, Florian; Quan, Jiamin; Bushati, Rezlind; Diederich, Geoffrey M.; Florian, Matthias; Klein, Julian; Mosina, Kseniia; Sofer, Zdenek; Xu, Xiaodong; Kamra, Akashdeep; Garcia-Vidal, Francisco J.; Alu, Andrea; Menon, Vinod M.
作者单位：City University of New York (CUNY) System; City University of New York (CUNY) System; City University of New York (CUNY) System; City University of New York (CUNY) System; City College of New York (CUNY); University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Massachusetts Institute of Technology (MIT); University of Chemistry & Technology, Prague; Autonomous University of Madrid
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作者：[Anonymous]
