作者：[Anonymous]
摘要：Strategies for public engagement need to be rigorously tested around the world to maximize the potential of immunization.
作者：Kong, Lingmei; Sun, Yuqi; Zhao, Bin; Ji, Kangyu; Feng, Jie; Dong, Jianchao; Wang, Yuanzhi; Liu, Zirui; Maqbool, Shabnum; Li, Yunguo; Yang, Yingguo; Dai, Linjie; Lee, Wanhee; Cho, Changsoon; Stranks, Samuel D.; Friend, Richard H.; Wang, Ning; Greenham, Neil C.; Yang, Xuyong
作者：Wiegand, Tanner; Hoffmann, Florian T.; Walker, Matt W. G.; Tang, Stephen; Richard, Egill; Le, Hoang C.; Meers, Chance; Sternberg, Samuel H.
作者单位：Columbia University; Columbia University
摘要：Transposon-encoded tnpB and iscB genes encode RNA-guided DNA nucleases that promote their own selfish spread through targeted DNA cleavage and homologous recombination(1-4). These widespread gene families were repeatedly domesticated over evolutionary timescales, leading to the emergence of diverse CRISPR-associated nucleases including Cas9 and Cas12 (refs. (5,6)). We set out to test the hypothesis that TnpB nucleases may have also been repurposed for novel, unexpected functions other than CRI...
