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作者:[Anonymous]
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作者:Su, Yujuan; Xu, Jinhao; Zhu, Ziai; Chin, Jisun; Xu, Le; Yu, Haoze; Nudell, Victoria; Dash, Barsha; Moya, Esteban A.; Ye, Li; Nimmerjahn, Axel; Sun, Xin
作者单位:University of California System; University of California San Diego; University of California System; University of California San Diego; Scripps Research Institute; La Jolla Institute for Immunology; University of California System; University of California San Diego; Salk Institute
摘要:Exaggerated airway constriction triggered by repeated exposure to allergen, also called hyperreactivity, is a hallmark of asthma. Whereas vagal sensory neurons are known to function in allergen-induced hyperreactivity(1-3), the identity of downstream nodes remains poorly understood. Here we mapped a full allergen circuit from the lung to the brainstem and back to the lung. Repeated exposure of mice to inhaled allergen activated the nuclei of solitary tract (nTS) neurons in a mast cell-, interl...
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作者:Co, Hannah K. C.; Wu, Chia-Chou; Lee, Yi-Chen; Chen, Sheng-hong
作者单位:Academia Sinica - Taiwan; National Defense Medical University; Academia Sinica - Taiwan; Academia Sinica - Taiwan; National Taiwan University
摘要:Large-scale cell death is commonly observed during organismal development and in human pathologies1-5. These cell death events extend over great distances to eliminate large populations of cells, raising the question of how cell death can be coordinated in space and time. One mechanism that enables long-range signal transmission is trigger waves6, but how this mechanism might be used for death events in cell populations remains unclear. Here we demonstrate that ferroptosis, an iron- and lipid-...
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作者:Stott, Peter
作者单位:Met Office - UK; University of Exeter
摘要:Drama behind the scenes at the Kyoto Protocol negotiations is laid bare in a major theatrical production.
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作者:[Anonymous]
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作者:Gibney, Elizabeth
摘要:The world's biggest fusion-energy experiment is likely to be beaten to its goals by other projects - but the massive reactor still has value, say scientists.
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作者:Jamal, Shihab
摘要:Researchers describe how they developed extraordinary physical skills for their research and how to stay calm in the face of risks.
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作者:Liao, Zhongkai; Zhang, Congcong
作者单位:Hainan Medical University
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作者:Zhang, Yanxian; Chou, Danny Hung-Chieh
作者单位:Stanford University; Stanford University
摘要:The need to keep therapeutic proteins, such as insulin, constantly cold can limit access to life-saving medicines. An advanced gel offers a possible solution to this issue - and might solve problems beyond health-care logistics.
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作者:Fornaro, Lorenzo; Crea, Francesco
作者单位:University of Pisa; Azienda Ospedaliero Universitaria Pisana; Open University - UK