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作者：Yu, Haoxuan
作者单位：University of Cambridge
摘要：From weakening jet streams to causing bumpier flights, climate change is altering atmospheric behaviour. Researchers need to find out how.
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作者：Baltgalvis, Kristen A.; Lamb, Kelsey N.; Symons, Kent T.; Wu, Chu-Chiao; Hoffman, Melissa A.; Snead, Aaron N.; Song, Xiaodan; Glaza, Thomas; Kikuchi, Shota; Green, Jason C.; Rogness, Donald C.; Lam, Betty; Rodriguez-Aguirre, Maria E.; Woody, David R.; Eissler, Christie L.; Rodiles, Socorro; Negron, Seth M.; Bernard, Steffen M.; Tran, Eileen; Pollock, Jonathan; Tabatabaei, Ali; Contreras, Victor; Williams, Heather N.; Pastuszka, Martha K.; Sigler, John J.; Pettazzoni, Piergiorgio; Rudolph, Markus G.; Classen, Moritz; Brugger, Doris; Claiborne, Christopher; Plancher, Jean-Marc; Cuartas, Isabel; Seoane, Joan; Burgess, Laurence E.; Abraham, Robert T.; Weinstein, David S.; Simon, Gabriel M.; Patricelli, Matthew P.; Kinsella, Todd M.
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作者：Neupane, Sujaya; Fiete, Ila; Jazayeri, Mehrdad
作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
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作者：Marsicano, Claudia A.; Pardo, Jason D.; Smith, Roger M. H.; Mancuso, Adriana C.; Gaetano, Leandro C.; Mocke, Helke
作者单位：University of Buenos Aires; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET); University of Buenos Aires; Field Museum of Natural History (Chicago); University of Witwatersrand; Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
摘要：Current hypotheses of early tetrapod evolution posit close ecological and biogeographic ties to the extensive coal-producing wetlands of the Carboniferous palaeoequator with rapid replacement of archaic tetrapod groups by relatives of modern amniotes and lissamphibians in the late Carboniferous (about 307 million years ago). These hypotheses draw on a tetrapod fossil record that is almost entirely restricted to palaeoequatorial Pangea (Laurussia)1,2. Here we describe a new giant stem tetrapod,...
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作者：Goncalves, Judith; Dixon, Scott J.
作者单位：Stanford University
摘要：An unusual form of cell death called ferroptosis can sweep over embryonic tissues in a wave-like manner to ensure proper muscle development - evidence that ferroptosis has a role in normal physiology.
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作者：Pamer, Eric G.
作者单位：University of Chicago
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作者：Gaertner, Florian; Ishikawa-Ankerhold, Hellen; Stutte, Susanne; Fu, Wenwen; Weitz, Jutta; Dueck, Anne; Nelakuditi, Bhavishya; Fumagalli, Valeria; van den Heuvel, Dominic; Belz, Larissa; Sobirova, Gulnoza; Zhang, Zhe; Titova, Anna; Navarro, Alejandro Martinez; Pekayvaz, Kami; Lorenz, Michael; von Baumgarten, Louisa; Kranich, Jan; Straub, Tobias; Popper, Bastian; Zheden, Vanessa; Kaufmann, Walter Anton; Guo, Chenglong; Piontek, Guido; von Stillfried, Saskia; Boor, Peter; Colonna, Marco; Clauss, Sebastian; Schulz, Christian; Brocker, Thomas; Walzog, Barbara; Scheiermann, Christoph; Aird, William C.; Nerlov, Claus; Stark, Konstantin; Petzold, Tobias; Engelhardt, Stefan; Sixt, Michael; Hauschild, Robert; Rudelius, Martina; Oostendorp, Robert A. J.; Iannacone, Matteo; Heinig, Matthias; Massberg, Steffen
作者单位：University of Munich; Institute of Science & Technology - Austria; German Centre for Cardiovascular Research; Munich Heart Alliance; University of Munich; University of Munich; University of Munich; Technical University of Munich; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; Technical University of Munich; Vita-Salute San Raffaele University; IRCCS Ospedale San Raffaele; Vita-Salute San Raffaele University; University of Munich; University of Munich; University of Munich; University of Munich; RWTH Aachen University; RWTH Aachen University Hospital; Washington University (WUSTL); University of Geneva; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; University of Oxford; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; German Centre for Cardiovascular Research; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Technical University of Munich
摘要：Platelet homeostasis is essential for vascular integrity and immune defence(1,2). Although the process of platelet formation by fragmenting megakaryocytes (MKs; thrombopoiesis) has been extensively studied, the cellular and molecular mechanisms required to constantly replenish the pool of MKs by their progenitor cells (megakaryopoiesis) remains unclear(3,4). Here we use intravital imaging to track the cellular dynamics of megakaryopoiesis over days. We identify plasmacytoid dendritic cells (pD...
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作者：Sun, Kathie Y.; Bai, Xiaodong; Chen, Siying; Bao, Suying; Zhang, Chuanyi; Kapoor, Manav; Backman, Joshua; Joseph, Tyler; Maxwell, Evan; Mitra, George; Gorovits, Alexander; Mansfield, Adam; Boutkov, Boris; Gokhale, Sujit; Habegger, Lukas; Marcketta, Anthony; Locke, Adam E.; Ganel, Liron; Hawes, Alicia; Kessler, Michael D.; Sharma, Deepika; Staples, Jeffrey; Bovijn, Jonas; Gelfman, Sahar; Di Gioia, Alessandro; Rajagopal, Veera M.; Lopez, Alexander; Varela, Jennifer Rico; Alegre-Diaz, Jesus; Berumen, Jaime; Tapia-Conyer, Roberto; Kuri-Morales, Pablo; Torres, Jason; Emberson, Jonathan; Collins, Rory; Cantor, Michael; Thornton, Timothy; Kang, Hyun Min; Overton, John D.; Shuldiner, Alan R.; Cremona, M. Laura; Nafde, Mona; Baras, Aris; Abecasis, Goncalo; Marchini, Jonathan; Reid, Jeffrey G.; Salerno, William; Balasubramanian, Suganthi
作者单位：Regeneron; Universidad Nacional Autonoma de Mexico; Tecnologico de Monterrey; University of Oxford; University of Oxford
摘要：Rare coding variants that substantially affect function provide insights into the biology of a gene(1-3). However, ascertaining the frequency of such variants requires large sample sizes(4-8). Here we present a catalogue of human protein-coding variation, derived from exome sequencing of 983,578 individuals across diverse populations. In total, 23% of the Regeneron Genetics Center Million Exome (RGC-ME) data come from individuals of African, East Asian, Indigenous American, Middle Eastern and ...
