8023期

最新文章

• Guidelines on lab-grown embryo models are strong enough to meet ethical standards - and will build trust in science AI翻译
  作者：Sturmey, Roger
  作者单位：University of York - UK; University of Hull
  摘要：The UK code of practice for researchers working with stem-cell-based embryo models is designed to both reassure the public and provide valuable guidance to researchers.
• Three ways AI is changing the 2024 Olympics for athletes and fans AI翻译
  作者：Kulkarni, Sumeet
  摘要：From training to broadcasting, artificial intelligence will have an imprint on this year's event for the first time.
• Sources of gene expression variation in a globally diverse human cohort AI翻译
  作者：Taylor, Dylan J.; Chhetri, Surya B.; Tassia, Michael G.; Biddanda, Arjun; Yan, Stephanie M.; Wojcik, Genevieve L.; Battle, Alexis; McCoy, Rajiv C.
  作者单位：Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins University
  摘要：Genetic variation that influences gene expression and splicing is a key source of phenotypic diversity1-5. Although invaluable, studies investigating these links in humans have been strongly biased towards participants of European ancestries, which constrains generalizability and hinders evolutionary research. Here to address these limitations, we developed MAGE, an open-access RNA sequencing dataset of lymphoblastoid cell lines from 731 individuals from the 1000 Genomes Project6, spread acros...
• Molecular mechanism of ligand gating and opening of NMDA receptor AI翻译
  作者：Chou, Tsung-Han; Epstein, Max; Fritzemeier, Russell G.; Akins, Nicholas S.; Paladugu, Srinu; Ullman, Elijah Z.; Liotta, Dennis C.; Traynelis, Stephen F.; Furukawa, Hiro
  作者单位：Cold Spring Harbor Laboratory; Emory University; Emory University; Emory University
  摘要：Glutamate transmission and activation of ionotropic glutamate receptors are the fundamental means by which neurons control their excitability and neuroplasticity1. The N-methyl-d-aspartate receptor (NMDAR) is unique among all ligand-gated channels, requiring two ligands-glutamate and glycine-for activation. These receptors function as heterotetrameric ion channels, with the channel opening dependent on the simultaneous binding of glycine and glutamate to the extracellular ligand-binding domain...
• Wasted renewables deny households cheap energy AI翻译
  作者：Foteinis, Spyros
  作者单位：Heriot Watt University
• Are our rock-climbing shoes shedding plastics? AI翻译
  作者：Gewin, Virginia; Sherman, Anya
  作者单位：University of Vienna
  摘要：Environmental scientist Anya Sherman studies how microplastics can be taken up by crops and people.
• How to improve assessments of publication integrity AI翻译
  作者：Grey, Andrew; Avenell, Alison; Klein, Andrew A.; Byrne, Jennifer A.; Wilmshurst, Peter; Bolland, Mark J.
  作者单位：University of Auckland; University of Aberdeen; Papworth Hospital; University of Sydney
  摘要：Too often, journal assessments of potentially unreliable research are superficial, opaque and prolonged. Changes to the guidance given by the Committee on Publication Ethics could tighten up the process.
• V. Craig Jordan obituary: pharmacologist who revolutionized breast cancer treatments AI翻译
  作者：Abderrahman, Balkees
  作者单位：University of Texas System; UTMD Anderson Cancer Center
  摘要：Pioneer of targeted therapy in cancer who turned failed contraceptive tamoxifen into an essential drug for treating breast cancer and osteoporosis.
• A psychedelic state arises from desynchronized brain activity AI翻译
  作者：Petridis, Petros D.
  摘要：After a person takes the psychedelic compound psilocybin, some of their brain networks dissolve - especially the one involved in the perception of self, space and time. Changes to the connections to this network can last for weeks. Psilocybin induces profound changes in brain connectivity.