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作者：Palffy, Adriana; Lopez-Urrutia, Jose R. Crespo
作者单位：University of Wurzburg; Max Planck Society
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作者：Chen, Sophia
摘要：In the hills of eastern Tennessee, a record-breaking machine called Frontier is providing scientists with unprecedented opportunities to study everything from atoms to galaxies.
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作者：Smith, Kerri
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作者：Smith, Roff
摘要：A survey of the Dolmen of Menga suggests that the stone tomb's Neolithic builders had an understanding of science.
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作者：Lim, Juhwan; Lee, Jung-In; Wang, Ye; Gauriot, Nicolas; Sebastian, Ebin; Chhowalla, Manish; Schnedermann, Christoph; Rao, Akshay
作者单位：University of Cambridge; University of Cambridge
摘要：Crystallographic phase engineering plays an important part in the precise control of the physical and electronic properties of materials. In two-dimensional transition metal dichalcogenides (2D TMDs), phase engineering using chemical lithiation with the organometallization agent n-butyllithium (n-BuLi), to convert the semiconducting 2H (trigonal) to the metallic 1T (octahedral) phase, has been widely explored for applications in areas such as transistors, catalysis and batteries1-15. Although ...
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作者：Zhang, Mingkai; Chapman, Matthew; Sarode, Bhagyesh R.; Xiong, Bingcong; Liang, Hao; Chen, James K.; Weerapana, Eranthie; Morken, James P.
作者单位：Boston College; Stanford University; Stanford University; Stanford University
摘要：Although aromatic rings are common elements in pharmaceutically active compounds, the presence of these motifs brings several liabilities with respect to the developability of a drug(1). Nonoptimal potency, metabolic stability, solubility and lipophilicity in pharmaceutical compounds can be improved by replacing aromatic rings with non-aromatic isosteric motifs(2). Moreover, whereas aromatic rings are planar and lack three-dimensionality, the binding pockets of most pharmaceutical targets are ...
