8028期

最新文章

• Frequency ratio of the 229mTh nuclear isomeric transition and the 87Sr atomic clock AI翻译
  作者：Zhang, Chuankun; Ooi, Tian; Higgins, Jacob S.; Doyle, Jack F.; von der Wense, Lars; Beeks, Kjeld; Leitner, Adrian; Kazakov, Georgy A.; Li, Peng; Thirol, Peter G.; Schumm, Thorsten; Ye, Jun
  作者单位：University of Colorado System; University of Colorado Boulder; National Institute of Standards & Technology (NIST) - USA; University of Colorado System; University of Colorado Boulder; Technische Universitat Wien; University of Munich; Johannes Gutenberg University of Mainz; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
  摘要：Optical atomic clocks(1,2) use electronic energy levels to precisely keep track of time. A clock based on nuclear energy levels promises a next-generation platform for precision metrology and fundamental physics studies. Thorium-229 nuclei exhibit a uniquely low-energy nuclear transition within reach of state-of-the-art vacuum ultraviolet (VUV) laser light sources and have, therefore, been proposed for construction of a nuclear clock(3,4). However, quantum-state-resolved spectroscopy of the Th...
• Centre global equity for mental-health research AI翻译
  作者：Chebii, Vivien
  作者单位：University of Witwatersrand
• MPOX IS SPREADING - THESE ARE SCIENTISTS' KEY QUESTIONS AI翻译
  作者：Reardon, Sara
• Exclusive: the papers that most heavily cite retracted studies AI翻译
  作者：Van Noorden, Richard; Naddaf, Miryam
  摘要：Data from giant project show how withdrawn research propagates through the literature.
• THICK AND THIN: WHAT TYPE OF PAPER CAUSES MOST CUTS? AI翻译
  作者：[Anonymous]
• Effective realization of abatement measures can reduce HFC-23 emissions AI翻译
  作者：Rust, Dominique; Vollmer, Martin K.; Henne, Stephan; Frumau, Arnoud; van den Bulk, Pim; Hensen, Arjan; Stanley, Kieran M.; Zenobi, Renato; Emmenegger, Lukas; Reimann, Stefan
  作者单位：Swiss Federal Institutes of Technology Domain; Swiss Federal Laboratories for Materials Science & Technology (EMPA); Swiss Federal Institutes of Technology Domain; ETH Zurich; Netherlands Organization Applied Science Research; University of Bristol
  摘要：HFC-23 is a potent greenhouse gas, predominantly emitted as an undesired by-product during the synthesis and processing of HCFC-22 (ref.(1)). Previously, the Clean Development Mechanism and national efforts called for the implementation of abatement technology for reducing HFC-23 emissions(2,3). Nevertheless, between 2015 and 2019, a divergence was found between the global emissions derived from atmospheric observations and those expected from reported abatement(1,2). Primarily, this points to...
• Mechanisms that clear mutations drive field cancerization in mammary tissue AI翻译
  作者：Ciwinska, Marta; Messal, Hendrik A.; Hristova, Hristina R.; Lutz, Catrin; Bornes, Laura; Chalkiadakis, Theofilos; Harkes, Rolf; Langedijk, Nathalia S. M.; Hutten, Stefan J.; Menezes, Renee X.; Jonkers, Jos; Prekovic, Stefan; Simons, Benjamin D.; Scheele, Colinda L. G. J.; van Rheenen, Jacco
  作者单位：Flanders Institute for Biotechnology (VIB); KU Leuven; Netherlands Cancer Institute; Utrecht University; Utrecht University Medical Center; Netherlands Cancer Institute; Netherlands Cancer Institute; Netherlands Cancer Institute; University of Cambridge; University of Cambridge; University of Cambridge
  摘要：Oncogenic mutations are abundant in the tissues of healthy individuals, but rarely form tumours1-3. Yet, the underlying protection mechanisms are largely unknown. To resolve these mechanisms in mouse mammary tissue, we use lineage tracing to map the fate of wild-type and Brca1-/-;Trp53-/- cells, and find that both follow a similar pattern of loss and spread within ducts. Clonal analysis reveals that ducts consist of small repetitive units of self-renewing cells that give rise to short-lived de...
• The genomic landscape of 2,023 colorectal cancers AI翻译
  作者：Cornish, Alex J.; Gruber, Andreas J.; Kinnersley, Ben; Chubb, Daniel; Frangou, Anna; Caravagna, Giulio; Noyvert, Boris; Lakatos, Eszter; Wood, Henry M.; Thorn, Steve; Culliford, Richard; Arnedo-Pac, Claudia; Househam, Jacob; Cross, William; Sud, Amit; Law, Philip; Ni Leathlobhair, Maire; Hawari, Aliah; Woolley, Connor; Sherwood, Kitty; Feeley, Nathalie; Guel, Gueler; Fernandez-Tajes, Juan; Zapata, Luis; Alexandrov, Ludmil B.; Murugaesu, Nirupa; Sosinsky, Alona; Mitchell, Jonathan; Lopez-Bigas, Nuria; Quirke, Philip; Church, David N.; Tomlinson, Ian P. M.; Sottoriva, Andrea; Graham, Trevor A.; Wedge, David C.; Houlston, Richard S.
  作者单位：University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; University of Konstanz; University of Manchester; University of London; University College London; University of Oxford; Max Planck Society; University of Trieste; Royal Marsden NHS Foundation Trust; University of London; Institute of Cancer Research - UK; University of Birmingham; Cancer Research UK; University of Birmingham; Chalmers University of Technology; University of Leeds; University of Oxford; Barcelona Institute of Science & Technology; Institute for Research in Biomedicine - IRB Barcelona; CIBER - Centro de Investigacion Biomedica en Red; CIBERONC; ICREA; University of London; University College London; Trinity College Dublin; University of Edinburgh; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California San Diego; University of London; Queen Mary University London; University of Oxford; Wellcome Centre for Human Genetics; Oxford University Hospitals NHS Foundation Trust; Human Technopole
  摘要：Colorectal carcinoma (CRC) is a common cause of mortality(1), but a comprehensive description of its genomic landscape is lacking(2-9). Here we perform whole-genome sequencing of 2,023 CRC samples from participants in the UK 100,000 Genomes Project, thereby providing a highly detailed somatic mutational landscape of this cancer. Integrated analyses identify more than 250 putative CRC driver genes, many not previously implicated in CRC or other cancers, including several recurrent changes outsi...
• Montreal Protocol is no 'zombie' deal AI翻译
  作者：Zaelke, Durwood; Bledsoe, Paul
  作者单位：American University
• Remodelling of the translatome controls diet and its impact on tumorigenesis AI翻译
  作者：Yang, Haojun; Zingaro, Vincenzo Andrea; Lincoff, James; Tom, Harrison; Oikawa, Satoshi; Oses-Prieto, Juan A.; Edmondson, Quinn; Seiple, Ian; Shah, Hardik; Kajimura, Shingo; Burlingame, Alma L.; Grabe, Michael; Ruggero, Davide
  作者单位：University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Howard Hughes Medical Institute; Robert H. Lurie Comprehensive Cancer Center; University of Chicago; University of California System; University of California San Francisco
  摘要：Fasting is associated with a range of health benefits(1-6). How fasting signals elicit changes in the proteome to establish metabolic programmes remains poorly understood. Here we show that hepatocytes selectively remodel the translatome while global translation is paradoxically downregulated during fasting(7,8). We discover that phosphorylation of eukaryotic translation initiation factor 4E (P-eIF4E) is induced during fasting. We show that P-eIF4E is responsible for controlling the translatio...