8029期

最新文章

• Glycosphingolipid synthesis mediates immune evasion in KRAS-driven cancer AI翻译
  作者：Soula, Mariluz; Unlu, Gokhan; Welch, Rachel; Chudnovskiy, Aleksey; Uygur, Beste; Shah, Vyom; Alwaseem, Hanan; Bunk, Paul; Subramanyam, Vishvak; Yeh, Hsi-Wen; Khan, Artem; Heissel, Soren; Goodarzi, Hani; Victora, Gabriel D.; Beyaz, Semir; Birsoy, Kivanc
  作者单位：Rockefeller University; Rockefeller University; Cold Spring Harbor Laboratory; Rockefeller University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco
  摘要：Cancer cells frequently alter their lipids to grow and adapt to their environment(1-3). Despite the critical functions of lipid metabolism in membrane physiology, signalling and energy production, how specific lipids contribute to tumorigenesis remains incompletely understood. Here, using functional genomics and lipidomic approaches, we identified de novo sphingolipid synthesis as an essential pathway for cancer immune evasion. Synthesis of sphingolipids is surprisingly dispensable for cancer ...
• GREEN PASTURES: CUTTING BEEF'S CARBON HOOFPRINT AI翻译
  作者：[Anonymous]
• Prefrontal and lateral entorhinal neurons co-dependently learn item-outcome rules AI翻译
  作者：Jun, Heechul; Lee, Jason Y.; Bleza, Nicholas R.; Ichii, Ayana; Donohue, Jordan D.; Igarashi, Kei M.
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：The ability to learn novel items depends on brain functions that store information about items classified by their associated meanings and outcomes1-4, but the underlying neural circuit mechanisms of this process remain poorly understood. Here we show that deep layers of the lateral entorhinal cortex (LEC) contain two groups of 'item-outcome neurons': one developing activity for rewarded items during learning, and another for punished items. As mice learned an olfactory item-outcome associatio...
• Structural basis for the activity of the type VII CRISPR-Cas system AI翻译
  作者：Yang, Jie; Li, Xuzichao; He, Qiuqiu; Wang, Xiaoshen; Tang, Jingjing; Wang, Tongyao; Zhang, Yi; Yu, Feiyang; Zhang, Shuqin; Liu, Zhikun; Zhang, Lingling; Liao, Fumeng; Yin, Hang; Zhao, Haiyan; Deng, Zengqin; Zhang, Heng
  作者单位：Tianjin Medical University; Chinese Academy of Sciences; Wuhan Institute of Virology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Wuhan University; Hubei Jiangxia Laboratory
  摘要：The newly identified type VII CRISPR-Cas candidate system uses a CRISPR RNA-guided ribonucleoprotein complex formed by Cas5 and Cas7 proteins to target RNA1. However, the RNA cleavage is executed by a dedicated Cas14 nuclease, which is distinct from the effector nucleases of the other CRISPR-Cas systems. Here we report seven cryo-electron microscopy structures of the Cas14-bound interference complex at different functional states. Cas14, a tetrameric protein in solution, is recruited to the Ca...
• Update regulator guidance on animal research AI翻译
  作者：Marshall, Lindsay; Simmons, Rebecca; Sower, Greg
• The emerging view on the origin and early evolution of eukaryotic cells AI翻译
  作者：Vosseberg, Julian; van Hooff, Jolien J. E.; Kostlbacher, Stephan; Panagiotou, Kassiani; Tamarit, Daniel; Ettema, Thijs J. G.
  作者单位：Wageningen University & Research; Utrecht University
  摘要：The origin of the eukaryotic cell, with its compartmentalized nature and generally large size compared with bacterial and archaeal cells, represents a cornerstone event in the evolution of complex life on Earth. In a process referred to as eukaryogenesis, the eukaryotic cell is believed to have evolved between approximately 1.8 and 2.7 billion years ago from its archaeal ancestors, with a symbiosis with a bacterial (proto-mitochondrial) partner being a key event. In the tree of life, the branc...
• Observing the two-dimensional Bose glass in an optical quasicrystal AI翻译
  作者：Yu, Jr-Chiun; Bhave, Shaurya; Reeve, Lee; Song, Bo; Schneider, Ulrich
  作者单位：University of Cambridge; Industrial Technology Research Institute - Taiwan; Peking University; Peking University
  摘要：The presence of disorder substantially influences the behaviour of physical systems. It can give rise to slow or glassy dynamics, or to a complete suppression of transport as in Anderson insulators1, where normally extended wavefunctions such as light fields or electronic Bloch waves become exponentially localized. The combined effect of disorder and interactions is central to the richness of condensed-matter physics2. In bosonic systems, it can also lead to additional quantum states such as t...
• I make fake eyes for those who need them AI翻译
  作者：Nordling, Linda; Wasswa, Franklin
  摘要：As the only ocularist in Uganda, Franklin Wasswa produces customized prosthetic eyes for people who've lost their own to injury or disease.
• Chandrayaan-3 APXS elemental abundance measurements at lunar high latitude AI翻译
  作者：Vadawale, Santosh V.; Mithun, N. P. S.; Shanmugam, M.; Basu Sarbadhikari, Amit; Sinha, Rishitosh K.; Bhatt, Megha; Vijayan, S.; Srivastava, Neeraj; Shukla, Anil D.; Murty, S. V. S.; Bhardwaj, Anil; Acharya, Y. B.; Patel, Arpit R.; Adalaja, Hiteshkumar L.; Vaishnava, C. S.; Saiguhan, B. S. Bharath; Singh, Nishant; Kumar, Sushil; Painkra, Deepak Kumar; Srivastava, Yash; Nair, Varsha M.; Ladiya, Tinkal; Goyal, Shiv Kumar; Tiwari, Neeraj K.; Narendranath, Shyama; Pillai, Netra S.; Hait, Arup Kumar; Patinge, Aaditya; Kumar, Abhishek; Satya, Neeraj; Subramanian, Vivek R.; Navle, Sonal G.; Venkatesh, R. G.; Abraham, Lalitha; Suresh, K.; Amitabh
  作者单位：Department of Space (DoS), Government of India; Physical Research Laboratory - India; Department of Space (DoS), Government of India; Indian Space Research Organisation (ISRO); U R Rao Satellite Centre (URSC); Department of Space (DoS), Government of India; Indian Space Research Organisation (ISRO); Space Applications Centre (SAC)
  摘要：The elemental composition of the lunar surface provides insights into mechanisms of the formation and evolution of the Moon(1,2). The chemical composition of lunar regolith have so far been precisely measured using the samples collected by the Apollo, Luna and Chang'e 5 missions, which are from equatorial to mid-latitude regions(3,4); lunar meteorites, whose location of origin on the Moon is unknown(5,6); and the in situ measurement from the Chang'e 3 and Chang'e 4 missions(7-9), which are fro...
• Tuberculosis in otherwise healthy adults with inherited TNF deficiency AI翻译
  作者：Arias, Andres A.; Neehus, Anna-Lena; Ogishi, Masato; Meynier, Vincent; Krebs, Adam; Lazarov, Tomi; Lee, Angela M.; Arango-Franco, Carlos A.; Yang, Rui; Orrego, Julio; Corcini Berndt, Melissa; Rojas, Julian; Li, Hailun; Rinchai, Darawan; Erazo-Borras, Lucia; Han, Ji Eun; Pillay, Bethany; Ponsin, Khoren; Chaldebas, Matthieu; Philippot, Quentin; Bohlen, Jonathan; Rosain, Jeremie; Le Voyer, Tom; Janotte, Till; Amarajeeva, Krishnajina; Soudee, Camille; Brollo, Marion; Wiegmann, Katja; Marquant, Quentin; Seeleuthner, Yoann; Lee, Danyel; Laine, Candice; Kloos, Doreen; Bailey, Rasheed; Bastard, Paul; Keating, Narelle; Rapaport, Franck; Khan, Taushif; Moncada-Velez, Marcela; Camila Carmona, Maria; Obando, Catalina; Alvarez, Jesus; Carlos Catano, Juan; Martinez-Rosado, Larry Luber; Sanchez, Juan P.; Tejada-Giraldo, Manuela; L'Honneur, Anne-Sophie; Agudelo, Maria L.; Perez-Zapata, Lizet J.; Arboleda, Diana M.; Fernando Alzate, Juan; Cabarcas, Felipe; Zuluaga, Alejandra; Pelham, Simon J.; Ensser, Armin; Schmidt, Monika; Velasquez-Lopera, Margarita M.; Jouanguy, Emmanuelle; Puel, Anne; Kronke, Martin; Ghirardello, Stefano; Borghesi, Alessandro; Pahari, Susanta; Boisson, Bertrand; Pittaluga, Stefania; Ma, Cindy S.; Emile, Jean-Francois; Notarangelo, Luigi D.; Tangye, Stuart G.; Marr, Nico; Lachmann, Nico; Salvator, Helene; Schlesinger, Larry S.; Zhang, Peng; Glickman, Michael S.; Nathan, Carl F.; Geissmann, Frederic; Abel, Laurent; Luis Franco, Jose; Bustamante, Jacinta; Casanova, Jean-Laurent; Boisson-Dupuis, Stephanie
  作者单位：Universidad de Antioquia; Universidad de Antioquia; Rockefeller University; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Memorial Sloan Kettering Cancer Center; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Garvan Institute of Medical Research; University of New South Wales Sydney; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; INRAE; Universite Paris Saclay; University of Cologne; University of Cologne; Hannover Medical School; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Walter & Eliza Hall Institute; University of Melbourne; Jackson Laboratory; Universidad de Antioquia; Universite Paris Cite; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Cochin - APHP; Universidad de Antioquia; Universidad de Antioquia; University of Erlangen Nuremberg; Universidad de Antioquia; University of Cologne; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Swiss School of Public Health (SSPH+); Texas Biomedical Research Institute; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Ambroise-Pare - APHP; National Institutes of Health (NIH) - USA; Division of Intramural Research (DIR); NIH National Institute of Allergy & Infectious Diseases (NIAID); Sidra Medical & Research Center; Qatar Foundation (QF); Hamad Bin Khalifa University-Qatar; Hannover Medical School; Hospital Foch; Universite Paris Saclay; Howard Hughes Medical Institute; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP
  摘要：Severe defects in human IFN gamma immunity predispose individuals to both Bacillus Calmette-Guerin disease and tuberculosis, whereas milder defects predispose only to tuberculosis(1). Here we report two adults with recurrent pulmonary tuberculosis who are homozygous for a private loss-of-function TNF variant. Neither has any other clinical phenotype and both mount normal clinical and biological inflammatory responses. Their leukocytes, including monocytes and monocyte-derived macrophages (MDMs...