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作者：Angello, Nicholas H.; Friday, David M.; Hwang, Changhyun; Yi, Seungjoo; Cheng, Austin H.; Torres-Flores, Tiara C.; Jira, Edward R.; Wang, Wesley; Aspuru-Guzik, Alan; Burke, Martin D.; Schroeder, Charles M.; Diao, Ying; Jackson, Nicholas E.
作者单位：University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Toronto; Vector Institute for Artificial Intelligence; University of Toronto; Canadian Institute for Advanced Research (CIFAR); University of Toronto; University of Toronto; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
摘要：Artificial intelligence-guided closed-loop experimentation has emerged as a promising method for optimization of objective functions1,2, but the substantial potential of this traditionally black-box approach to uncovering new chemical knowledge has remained largely untapped. Here we report the integration of closed-loop experiments with physics-based feature selection and supervised learning, denoted as closed-loop transfer (CLT), to yield chemical insights in parallel with optimization of obj...
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作者：Marshall, Lindsay; Simmons, Rebecca; Sower, Greg
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作者：Paladini, Claudia
作者单位：European Southern Observatory
摘要：A powerful telescope array has imaged the surface of a star called R Doradus. The observations will help astronomers to understand the fluid dynamics of evolved giant stars - a type of star that the Sun will eventually become.
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作者：Cheng, Tianhe; Liu, Zhenzhen; Li, Haiming; Huang, Xiaorong; Wang, Wei; Shi, Ce; Zhang, Xuecheng; Chen, Hong; Yao, Zhuang; Zhao, Peng; Peng, Xiongbo; Sun, Meng-Xiang
作者单位：Wuhan University; Xiamen University
摘要：Fertilization introduces parental genetic information into the zygote to guide embryogenesis. Parental contributions to postfertilization development have been discussed for decades, and the data available show that both parents contribute to the zygotic transcriptome, suggesting a paternal role in early embryogenesis1-6. However, because the specific paternal effects on postfertilization development and the molecular pathways underpinning these effects remain poorly understood, paternal contr...
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作者：Wagner, Jonathan; Carvajal, Alonso I.; Bracher, Andreas; Beck, Florian; Wan, William; Bohn, Stefan; Koerner, Roman; Baumeister, Wolfgang; Fernandez-Busnadiego, Ruben; Hartl, F. Ulrich
作者单位：Max Planck Society; Max Planck Society; University of Gottingen; UNIVERSITY GOTTINGEN HOSPITAL; University of Gottingen; Max Planck Society; Vanderbilt University; Helmholtz Association; Helmholtz-Center Munich - German Research Center for Environmental Health; University of Gottingen
摘要：Chaperonins are large barrel-shaped complexes that mediate ATP-dependent protein folding(1-3). The bacterial chaperonin GroEL forms juxtaposed rings that bind unfolded protein and the lid-shaped cofactor GroES at their apertures. In vitro analyses of the chaperonin reaction have shown that substrate protein folds, unimpaired by aggregation, while transiently encapsulated in the GroEL central cavity by GroES(4-6). To determine the functional stoichiometry of GroEL, GroES and client protein in s...
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作者：Ji, Wenming; Miao, Anran; Liang, Kai; Liu, Jiameng; Qi, Yuhan; Zhou, Yue; Duan, Xinli; Sun, Jixue; Lai, Lipeng; Wu, Jing-Xiang
作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College
摘要：Norepinephrine transporter (NET; encoded by SLC6A2) reuptakes the majority of the released noradrenaline back to the presynaptic terminals, thereby affecting the synaptic noradrenaline level1. Genetic mutations and dysregulation of NET are associated with a spectrum of neurological conditions in humans, making NET an important therapeutic target1. However, the structure and mechanism of NET remain unclear. Here we provide cryogenic electron microscopy structures of the human NET (hNET) in thre...
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作者：Malamud, Mariano; Whitehead, Lauren; Mcintosh, Alasdair; Colella, Fabio; Roelofs, Anke J.; Kusakabe, Takato; Dambuza, Ivy M.; Phillips-Brookes, Annie; Salazar, Fabian; Perez, Federico; Shoesmith, Romey; Zakrzewski, Przemyslaw; Sey, Emily A.; Rodrigues, Cecilia; Morvay, Petruta L.; Redelinghuys, Pierre; Bedekovic, Tina; Fernandes, Maria J. G.; Almizraq, Ruqayyah; Branch, Donald R.; Amulic, Borko; Harvey, Jamie; Stewart, Diane; Yuecel, Raif; Reid, Delyth M.; Mcconnachie, Alex; Pickering, Matthew C.; Botto, Marina; Iliev, Iliyan D.; McInnes, Iain B.; De Bari, Cosimo; Willment, Janet A.; Brown, Gordon D.
作者单位：University of Exeter; University of Aberdeen; University of Glasgow; University of Aberdeen; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; University of Toronto; Hospital for Sick Children (SickKids); University of Bristol; Laval University; Canadian Blood Services; University of Exeter; Imperial College London
摘要：Regulation of neutrophil activation is critical for disease control. Neutrophil extracellular traps (NETs), which are web-like structures composed of DNA and neutrophil-derived proteins, are formed following pro-inflammatory signals; however, if this process is uncontrolled, NETs contribute to disease pathogenesis, exacerbating inflammation and host tissue damage1,2. Here we show that myeloid inhibitory C-type lectin-like (MICL), an inhibitory C-type lectin receptor, directly recognizes DNA in...
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作者：van der Linden, Sander
作者单位：University of Cambridge
摘要：The engagement-fuelled logic of social media has bequeathed us a world in which what's trending is a yardstick for what's true.
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作者：Eren, A. Murat; Delmont, Tom O.
作者单位：Helmholtz Association; Alfred Wegener Institute, Helmholtz Centre for Polar & Marine Research; Carl von Ossietzky Universitat Oldenburg; Marine Biological Laboratory - Woods Hole; Max Planck Society; CEA; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS)
摘要：The direct recovery of microbial genomes from complex environments is now routine. Going from environmental genomes to laboratory experiments is rare, but the tide is turning.
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作者：Marshall, Lindsay; Simmons, Rebecca; Sower, Greg
摘要：Letter to the Editor
