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作者：Bailey, Chris; Pich, Oriol; Thol, Kerstin; Watkins, Thomas B. K.; Luebeck, Jens; Rowan, Andrew; Stavrou, Georgia; Weiser, Natasha E.; Dameracharla, Bhargavi; Bentham, Robert; Lu, Wei-Ting; Kittel, Jeanette; Yang, S. Y. Cindy; Howitt, Brooke E.; Sharma, Natasha; Litovchenko, Maria; Salgado, Roberto; Hung, King L.; Cornish, Alex J.; Moore, David A.; Houlston, Richard S.; Bafna, Vineet; Chang, Howard Y.; Nik-Zainal, Serena; Kanu, Nnennaya; McGranahan, Nicholas; Flanagan, Adrienne M.; Mischel, Paul S.; Jamal-Hanjani, Mariam; Swanton, Charles
作者单位：Francis Crick Institute; Cancer Research UK; University of London; University College London; University of London; University College London; Cancer Research UK; Stanford University; Stanford University; University of California System; University of California San Diego; University of London; University College London; Stanford University; Stanford University; Peter Maccallum Cancer Center; University of London; Institute of Cancer Research - UK; Royal Marsden NHS Foundation Trust; University College London Hospitals NHS Foundation Trust; University of London; University College London; University of Cambridge; University of London; University College London; University of London; University College London; Royal National Orthopaedic Hospital NHS Trust; University College London Hospitals NHS Foundation Trust; University of London; University College London
摘要：Extrachromosomal DNA (ecDNA) is a major contributor to treatment resistance and poor outcome for patients with cancer1,2. Here we examine the diversity of ecDNA elements across cancer, revealing the associated tissue, genetic and mutational contexts. By analysing data from 14,778 patients with 39 tumour types from the 100,000 Genomes Project, we demonstrate that 17.1% of tumour samples contain ecDNA. We reveal a pattern highly indicative of tissue-context-based selection for ecDNAs, linking th...
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作者：Murray, Claire
摘要：When research on an intriguing material called for hundreds of samples, secondary-school students, teachers and technicians stepped up.
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作者：Wan, Zhong; Qian, Qi; Huang, Yu; Duan, Xiangfeng
作者单位：University of California System; University of California Los Angeles; The Chinese University of Hong Kong, Shenzhen; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles
摘要：Crystalline solids typically show robust long-range structural ordering, vital for their remarkable electronic properties and use in functional electronics, albeit with limited customization space. By contrast, synthetic molecular systems provide highly tunable structural topologies and versatile functionalities but are often too delicate for scalable electronic integration. Combining these two systems could harness the strengths of both, yet realizing this integration is challenging owing to ...
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作者：Tourrette, Elise; Torres, Roberto C.; Svensson, Sarah L.; Matsumoto, Takashi; Miftahussurur, Muhammad; Fauzia, Kartika Afrida; Alfaray, Ricky Indra; Vilaichone, Ratha-Korn; Vo Phuoc Tuan; Wang, Difei; Yadegar, Abbas; Olsson, Lisa M.; Zhou, Zhemin; Yamaoka, Yoshio; Thorell, Kaisa; Falush, Daniel
作者单位：Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS; Oita University; Airlangga University; Thammasat University; Thammasat University; Cho Ray Hospital; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; Shahid Beheshti University Medical Sciences; University of Gothenburg; Soochow University - China; Baylor College of Medicine; Oita University; University of Gothenburg
摘要：Helicobacter pylori disturbs the stomach lining during long-term colonization of its human host, with sequelae including ulcers and gastric cancer(1,2). Numerous H. pylori virulence factors have been identified, showing extensive geographic variation(1). Here we identify a 'Hardy' ecospecies of H. pylori that shares the ancestry of 'Ubiquitous' H. pylori from the same region in most of the genome but has nearly fixed single-nucleotide polymorphism differences in 100 genes, many of which encode...
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作者：Nguyen, Duy D.; Hooper, William F.; Liu, Weisi; Chu, Timothy R.; Geiger, Heather; Shelton, Jennifer M.; Shah, Minita; Goldstein, Zoe R.; Winterkorn, Lara; Helland, Adrienne; Sigouros, Michael; Manohar, Jyothi; Moyer, Jenna; Al Assaad, Majd; Semaan, Alissa; Cohen, Sandra; Rowdo, Florencia Madorsky; Wilkes, David; Osman, Mohamed; Singh, Rahul R.; Sboner, Andrea; Valentine, Henkel L.; Abbosh, Phillip; Tagawa, Scott T.; Nanus, David M.; Nauseef, Jones T.; Sternberg, Cora N.; Molina, Ana M.; Scherr, Douglas; Inghirami, Giorgio; Mosquera, Juan Miguel; Elemento, Olivier; Robine, Nicolas; Faltas, Bishoy M.
作者单位：Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Fox Chase Cancer Center; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine; Cornell University; Weill Cornell Medicine
摘要：Advanced urothelial cancer is a frequently lethal disease characterized by marked genetic heterogeneity(1). In this study, we investigated the evolution of genomic signatures caused by endogenous and external mutagenic processes and their interplay with complex structural variants (SVs). We superimposed mutational signatures and phylogenetic analyses of matched serial tumours from patients with urothelial cancer to define the evolutionary dynamics of these processes. We show that APOBEC3-induc...
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作者：Jain, Anant; Nakahata, Yoshihisa; Pancani, Tristano; Watabe, Tetsuya; Rusina, Polina; South, Kelly; Adachi, Kengo; Yan, Long; Simorowski, Noriko; Furukawa, Hiro; Yasuda, Ryohei
作者单位：Max Planck Society; Cold Spring Harbor Laboratory
摘要：Behavioural time scale plasticity (BTSP) is non-Hebbian plasticity induced by integrating presynaptic and postsynaptic components separated by a behaviourally relevant time scale (seconds)1. BTSP in hippocampal CA1 neurons underlies place cell formation. However, the molecular mechanisms that enable synapse-specific plasticity on a behavioural time scale are unknown. Here we show that BTSP can be induced in a single dendritic spine using two-photon glutamate uncaging paired with postsynaptic c...
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作者：Forrester, Nikki; Gonzalez, Ana
作者单位：Environment & Climate Change Canada; Canadian Wildlife Service
摘要：Ornithologist Ana Gonzalez studies migration patterns and works with local scientists to protect threatened birds.
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作者：Jones, Julia P. G.
作者单位：Bangor University
摘要：An eloquent requiem for nature risks leaving the reader feeling helpless rather than energized.
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作者：Lenharo, Mariana
摘要：Giving faecal transplants to children born by caesarian section is promising, early clinical trial results show.
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作者：Cazabonne, Jonathan; Haelewaters, Danny
作者单位：University of Quebec; University Quebec Abitibi-Temiscamingue; Czech Academy of Sciences; Biology Centre of the Czech Academy of Sciences
