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作者：Tacikowski, Pawel; Kalender, Guldamla; Ciliberti, Davide; Fried, Itzhak
作者单位：University of California System; University of California Los Angeles; Karolinska Institutet; Universidade de Coimbra; University of California System; University of California Los Angeles; Tel Aviv University; University of Minnesota System; University of Minnesota Twin Cities; Otto von Guericke University
摘要：Extracting the underlying temporal structure of experience is a fundamental aspect of learning and memory that allows us to predict what is likely to happen next. Current knowledge about the neural underpinnings of this cognitive process in humans stems from functional neuroimaging research1-5. As these methods lack direct access to the neuronal level, it remains unknown how this process is computed by neurons in the human brain. Here we record from single neurons in individuals who have been ...
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作者：Huynh, Pacific; Hoffmann, Jan D.; Gerhardt, Teresa; Kiss, Mate G.; Zuraikat, Faris M.; Cohen, Oren; Wolfram, Christopher; Yates, Abi G.; Leunig, Alexander; Heiser, Merlin; Gaebel, Lena; Gianeselli, Matteo; Goswami, Sukanya; Khamhoung, Annie; Downey, Jeffrey; Yoon, Seonghun; Chen, Zhihong; Roudko, Vladimir; Dawson, Travis; Ferreira da Silva, Joana; Ameral, Natalie J.; Morgenroth-Rebin, Jarod; D'Souza, Darwin; Koekkoek, Laura L.; Jacob, Walter; Munitz, Jazz; Lee, Donghoon; Fullard, John F.; van Leent, Mandy M. T.; Roussos, Panos; Kim-Schulze, Seunghee; Shah, Neomi; Kleinstiver, Benjamin P.; Swirski, Filip K.; Leistner, David; St-Onge, Marie-Pierre; McAlpine, Cameron S.
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; German Heart Center Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Columbia University; NewYork-Presbyterian Hospital; NewYork-Presbyterian Hospital; Columbia University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Goethe University Frankfurt; Goethe University Frankfurt Hospital
摘要：Sleep is integral to cardiovascular health1,2. Yet, the circuits that connect cardiovascular pathology and sleep are incompletely understood. It remains unclear whether cardiac injury influences sleep and whether sleep-mediated neural outputs contribute to heart healing and inflammation. Here we report that in humans and mice, monocytes are actively recruited to the brain after myocardial infarction (MI) to augment sleep, which suppresses sympathetic outflow to the heart, limiting inflammation...
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作者：You, Linlin; Wang, Chengyuan; Molodtsov, Vadim; Kuznedelov, Konstantin; Miao, Xinyi; Wenck, Breanna R.; Ulisse, Paul; Sanders, Travis J.; Marshall, Craig J.; Firlar, Emre; Kaelber, Jason T.; Santangelo, Thomas J.; Ebright, Richard H.
作者单位：Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick; Chinese Academy of Sciences; Shanghai Institute of Immunity and Infection, CAS; Colorado State University System; Colorado State University Fort Collins; Rutgers University System; Rutgers University New Brunswick; Rutgers University System; Rutgers University New Brunswick
摘要：The ribonuclease FttA (also known as aCPSF and aCPSF1) mediates factor-dependent transcription termination in archaea1-3. Here we report the structure of a Thermococcus kodakarensis transcription pre-termination complex comprising FttA, Spt4, Spt5 and a transcription elongation complex (TEC). The structure shows that FttA interacts with the TEC in a manner that enables RNA to proceed directly from the TEC RNA-exit channel to the FttA catalytic centre and that enables endonucleolytic cleavage o...
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作者：Castelvecchi, Davide
摘要：Contracts with Google and Amazon could help, but bringing new types of reactor online will take larger investments - and time.
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作者：Hussein, Hussam; Awad, Abdullah
作者单位：University of Oxford
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作者：Tautz, Diethard
作者单位：Max Planck Society; Stellenbosch University
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作者：Cazabonne, Jonathan; Haelewaters, Danny
作者单位：University of Quebec; University Quebec Abitibi-Temiscamingue; Czech Academy of Sciences; Biology Centre of the Czech Academy of Sciences
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作者：[Anonymous]
摘要：Trillions of dollars are needed to prevent and protect against global warming. But who should pay? The world's climate scientific advisory body could help countries to decide. Close-up of the logo for the COP29 Climate Change Conference painted on a road in Baku
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作者：Koegel, Alexander; Keidel, Achim; Loukeri, Matina-Jasemi; Kuhn, Christopher C.; Langer, Lukas M.; Schaefer, Ingmar B.; Conti, Elena
作者单位：Max Planck Society; Technische Universitat Dresden; Technische Universitat Dresden; German Center for Diabetes Research (DZD)
摘要：The interplay between translation and mRNA decay is widespread in human cells1-3. In quality-control pathways, exonucleolytic degradation of mRNA associated with translating ribosomes is mediated largely by the cytoplasmic exosome4-9, which includes the exoribonuclease complex EXO10 and the helicase complex SKI238 (refs. 10-16). The helicase can extract mRNA from the ribosome and is expected to transfer it to the exoribonuclease core through a bridging factor, HBS1L3 (also known as SKI7), but ...
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作者：Zhou, Zihui; Ma, Tianqiong; Zhang, Heyang; Chheda, Saumil; Li, Haozhe; Wang, Kaiyu; Ehrling, Sebastian; Giovine, Raynald; Li, Chuanshuai; Alawadhi, Ali H.; Abduljawad, Marwan M.; Alawad, Majed O.; Gagliardi, Laura; Sauer, Joachim; Yaghi, Omar M.
作者单位：University of California System; University of California Berkeley; University of California System; University of California Berkeley; University of California System; University of California Berkeley; King Abdulaziz City for Science & Technology; University of Chicago; University of Chicago; Humboldt University of Berlin
摘要：Capture of CO2 from the air offers a promising approach to addressing climate change and achieving carbon neutrality goals(1,2). However, the development of a durable material with high capacity, fast kinetics and low regeneration temperature for CO2 capture, especially from the intricate and dynamic atmosphere, is still lacking. Here a porous, crystalline covalent organic framework (COF) with olefin linkages has been synthesized, structurally characterized and post-synthetically modified by t...
