8038期

最新文章

• Ignoring journal metrics on CVs is an act of privilege AI翻译
  作者：Souza-Neto, Valerio
  作者单位：Griffith University
• No hearing aids needed: bats' ears stay keen well into old age AI翻译
  作者：[Anonymous]
• Temporally distinct 3D multi-omic dynamics in the developing human brain AI翻译
  作者：Heffel, Matthew G.; Zhou, Jingtian; Zhang, Yi; Lee, Dong-Sung; Hou, Kangcheng; Pastor-Alonso, Oier; Abuhanna, Kevin D.; Galasso, Joseph; Kern, Colin; Tai, Chu-Yi; Garcia-Padilla, Carlos; Nafisi, Mahsa; Zhou, Yi; Schmitt, Anthony D.; Li, Terence; Haeussler, Maximilian; Wick, Brittney; Zhang, Martin Jinye; Xie, Fangming; Ziffra, Ryan S.; Mukamel, Eran A.; Eskin, Eleazar; Nowakowski, Tomasz J.; Dixon, Jesse R.; Pasaniuc, Bogdan; Ecker, Joseph R.; Zhu, Quan; Bintu, Bogdan; Paredes, Mercedes F.; Luo, Chongyuan
  作者单位：University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Salk Institute; University of California System; University of California San Diego; Seoul National University (SNU); Seoul National University (SNU); University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California San Francisco; University of California System; University of California Los Angeles; University of California Los Angeles Medical Center; David Geffen School of Medicine at UCLA; University of California System; University of California San Diego; University of California System; University of California San Diego; University of California System; University of California Santa Cruz; Carnegie Mellon University; Harvard University; Harvard T.H. Chan School of Public Health; University of California System; University of California San Diego; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California Los Angeles; Salk Institute; Howard Hughes Medical Institute; Salk Institute; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：The human hippocampus and prefrontal cortex play critical roles in learning and cognition1,2, yet the dynamic molecular characteristics of their development remain enigmatic. Here we investigated the epigenomic and three-dimensional chromatin conformational reorganization during the development of the hippocampus and prefrontal cortex, using more than 53,000 joint single-nucleus profiles of chromatin conformation and DNA methylation generated by single-nucleus methyl-3C sequencing (snm3C-seq3)...
• Scientists must hold President Trump to account with courage and unity AI翻译
  作者：[Anonymous]
• Dopamine dynamics are dispensable for movement but promote reward responses AI翻译
  作者：Cai, Xintong; Liu, Changliang; Tsutsui-Kimura, Iku; Lee, Joon-Hyuk; Guo, Chong; Banerjee, Aditi; Lee, Jinoh; Amo, Ryunosuke; Xie, Yudi; Patriarchi, Tommaso; Li, Yulong; Watabe-Uchida, Mitsuko; Uchida, Naoshige; Kaeser, Pascal S.
  作者单位：Harvard University; Harvard Medical School; Harvard University; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; Peking University
  摘要：Dopamine signalling modes differ in kinetics and spatial patterns of receptor activation1,2. How these modes contribute to motor function, motivation and learning has long been debated3-21. Here we show that action-potential-induced dopamine release is dispensable for movement initiation but supports reward-oriented behaviour. We generated mice with dopamine-neuron-specific knockout of the release site organizer protein RIM to disrupt action-potential-induced dopamine release. In these mice, r...
• CIRCULAR LOGIC: UNPICKING RNA'S STRANGEST FORM YET AI翻译
  作者：Dance, Amber
• Systemic biases are leading to an intersex research void AI翻译
  作者：Stokes, Alexander J.; Vary, Nick G.; Lorshbough, Erika L.
  作者单位：University of Hawaii System
• Selective ion transport through hydrated micropores in polymer membranes AI翻译
  作者：Wang, Anqi; Breakwell, Charlotte; Foglia, Fabrizia; Tan, Rui; Lovell, Louie; Wei, Xiaochu; Wong, Toby; Meng, Naiqi; Li, Haodong; Seel, Andrew; Sarter, Mona; Smith, Keenan; Alvarez-Fernandez, Alberto; Furedi, Mate; Guldin, Stefan; Britton, Melanie M.; McKeown, Neil B.; Jelfs, Kim E.; Song, Qilei
  作者单位：Imperial College London; Imperial College London; University of London; University College London; University of Birmingham; UK Research & Innovation (UKRI); Science & Technology Facilities Council (STFC); STFC Rutherford Appleton Laboratory; University of London; Royal Holloway University London; University of London; University College London; University of Edinburgh; King Abdullah University of Science & Technology
  摘要：Ion-conducting polymer membranes are essential in many separation processes and electrochemical devices, including electrodialysis1, redox flow batteries2, fuel cells3 and electrolysers4,5. Controlling ion transport and selectivity in these membranes largely hinges on the manipulation of pore size. Although membrane pore structures can be designed in the dry state6, they are redefined upon hydration owing to swelling in electrolyte solutions. Strategies to control pore hydration and a deeper u...
• Nuclear release of eIF1 restricts start-codon selection during mitosis AI翻译
  作者：Ly, Jimmy; Xiang, Kehui; Su, Kuan-Chung; Sissoko, Gunter B.; Bartel, David P.; Cheeseman, Iain M.
  作者单位：Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute
  摘要：Regulated start-codon selection has the potential to reshape the proteome through the differential production of upstream open reading frames, canonical proteins, and alternative translational isoforms1-3. However, conditions under which start codon selection is altered remain poorly defined. Here, using transcriptome-wide translation-initiation-site profiling4, we reveal a global increase in the stringency of start-codon selection during mammalian mitosis. Low-efficiency initiation sites are ...
• High CO2 dampens then amplifies N-induced diversity loss over 24 years AI翻译
  作者：Reich, Peter B.; Mohanbabu, Neha; Isbell, Forest; Hobbie, Sarah E.; Butler, Ethan E.
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Michigan System; University of Michigan; Western Sydney University; University of Minnesota System; University of Minnesota Twin Cities
  摘要：Rising levels of atmospheric carbon dioxide (CO2) and nitrogen (N) deposition affect plant communities in numerous ways(1-11). Nitrogen deposition causes local biodiversity loss globally(12-14), but whether, and if so how, rising CO2 concentrations amplify or dampen those losses remains unclear and is almost entirely unstudied. We addressed this knowledge gap with an open-air experiment in which 108 grassland plots were grown for 24 years under different CO2 and N regimes. We initially found t...