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作者：Molinaro, Dean D.; Scherpereel, Keaton L.; Schonhaut, Ethan B.; Evangelopoulos, Georgios; Shepherd, Max K.; Young, Aaron J.
作者单位：University System of Georgia; Georgia Institute of Technology; University System of Georgia; Georgia Institute of Technology; Northeastern University; Northeastern University; Alphabet Inc.; Google Incorporated
摘要：Lower-limb exoskeletons have the potential to transform the way we move1-14, but current state-of-the-art controllers cannot accommodate the rich set of possible human behaviours that range from cyclic and predictable to transitory and unstructured. We introduce a task-agnostic controller that assists the user on the basis of instantaneous estimates of lower-limb biological joint moments from a deep neural network. By estimating both hip and knee moments in-the-loop, our approach provided mult...
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作者：de March, Claire A.; Ma, Ning; Billesbolle, Christian B.; Tewari, Jeevan; del Torrent, Claudia Llinas; van der Velden, Wijnand J. C.; Ojiro, Ichie; Takayama, Ikumi; Faust, Bryan; Li, Linus; Vaidehi, Nagarajan; Manglik, Aashish; Matsunami, Hiroaki
作者单位：Duke University; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); City of Hope; Beckman Research Institute of City of Hope; University of California System; University of California San Francisco; University of Barcelona; Autonomous University of Barcelona; University of Shizuoka; Tokyo University of Agriculture & Technology; University of California System; University of California San Francisco; Duke University
摘要：How the olfactory system detects and distinguishes odorants with diverse physicochemical properties and molecular configurations remains poorly understood. Vertebrate animals perceive odours through G protein-coupled odorant receptors (ORs)1. In humans, around 400 ORs enable the sense of smell. The OR family comprises two main classes: class I ORs are tuned to carboxylic acids whereas class II ORs, which represent most of the human repertoire, respond to a wide variety of odorants2. A fundamen...
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作者：Klose, Immo; Patel, Calum; Mondal, Anirban; Schwarz, Andrew; Pupo, Gabriele; Gouverneur, Veronique
作者单位：University of Oxford
摘要：The dangerous chemical hydrogen fluoride sits at the apex of the fluorochemical industry, but the substantial hazards linked to its production under harsh conditions (above 300 degrees Celsius) and transport are typically contracted to specialists. All fluorochemicals for applications, including refrigeration, electric transportation, agrochemicals and pharmaceuticals, are prepared from fluorspar (CaF2) through a procedure that generates highly dangerous hydrogen fluoride1-5. Here we report a ...
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作者：Leckenby, Guy; Sidhu, Ragandeep Singh; Chen, Rui Jiu; Mancino, Riccardo; Szanyi, Balazs; Bai, Mei; Battino, Umberto; Blaum, Klaus; Brandau, Carsten; Cristallo, Sergio; Dickel, Timo; Dillmann, Iris; Dmytriiev, Dmytro; Faestermann, Thomas; Forstner, Oliver; Franczak, Bernhard; Geissel, Hans; Gernhaeuser, Roman; Glorius, Jan; Griffin, Chris; Gumberidze, Alexandre; Haettner, Emma; Hillenbrand, Pierre-Michel; Karakas, Amanda; Kaur, Tejpreet; Korten, Wolfram; Kozhuharov, Christophor; Kuzminchuk, Natalia; Langanke, Karlheinz; Litvinov, Sergey; Litvinov, Yuri A.; Lugaro, Maria; Martinez-Pinedo, Gabriel; Menz, Esther; Meyer, Bradley; Morgenroth, Tino; Neff, Thomas; Nociforo, Chiara; Petridis, Nikolaos; Pignatari, Marco; Popp, Ulrich; Purushothaman, Sivaji; Reifarth, Rene; Sanjari, Shahab; Scheidenberger, Christoph; Spillmann, Uwe; Steck, Markus; Stoehlker, Thomas; Tanaka, Yoshiki K.; Trassinelli, Martino; Trotsenko, Sergiy; Varga, Laszlo; Vescovi, Diego; Wang, Meng; Weick, Helmut; Yaguee Lopez, Andres; Yamaguchi, Takayuki; Zhang, Yuhu; Zhao, Jianwei
作者单位：University of British Columbia; University of British Columbia; Helmholtz Association; GSI Helmholtz-Center for Heavy Ion Research; University of Edinburgh; Max Planck Society; Chinese Academy of Sciences; Institute of Modern Physics, CAS; Technical University of Darmstadt; Szeged University; HUN-REN; HUN-REN Research Centre for Astronomy & Earth Sciences; Konkoly Thege Miklos Astronomical Institute; University of Hull; Istituto Nazionale Astrofisica (INAF); Justus Liebig University Giessen; Istituto Nazionale Astrofisica (INAF); Istituto Nazionale di Fisica Nucleare (INFN); Justus Liebig University Giessen; University of Victoria; Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); Technical University of Munich; Friedrich Schiller University of Jena; Monash University; University of Tokyo; Panjab University; CEA; Universite Paris Saclay; Helmholtz Association; GSI Helmholtz-Center for Heavy Ion Research; Eotvos Lorand University; Clemson University; Goethe University Frankfurt; United States Department of Energy (DOE); Los Alamos National Laboratory; Helmholtz Association; GSI Helmholtz-Center for Heavy Ion Research; RIKEN; Centre National de la Recherche Scientifique (CNRS); Sorbonne Universite; Saitama University; Charles University Prague
摘要：Radioactive nuclei with lifetimes on the order of millions of years can reveal the formation history of the Sun and active nucleosynthesis occurring at the time and place of its birth1,2. Among such nuclei whose decay signatures are found in the oldest meteorites, 205Pb is a powerful example, as it is produced exclusively by slow neutron captures (the s process), with most being synthesized in asymptotic giant branch (AGB) stars3-5. However, making accurate abundance predictions for 205Pb has ...
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作者：Naressi, Rafaella G.; Malnic, Bettina
作者单位：Universidade de Sao Paulo
摘要：How do odorant receptors in the human nose recognize a wide variety of scent molecules? The structures of engineered versions of these receptors finally provide much-needed answers to this fundamental question.
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作者：Wells, Sarah
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作者：[Anonymous]
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作者：Lake, Nicole J.; Ma, Kaiyue; Liu, Wei; Battle, Stephanie L.; Laricchia, Kristen M.; Tiao, Grace; Puiu, Daniela; Ng, Kenneth K.; Cohen, Justin; Compton, Alison G.; Cowie, Shannon; Christodoulou, John; Thorburn, David R.; Zhao, Hongyu; Arking, Dan E.; Sunyaev, Shamil R.; Lek, Monkol
作者单位：Yale University; Murdoch Children's Research Institute; Royal Children's Hospital Melbourne; Yale University; Johns Hopkins University; University System of Maryland; Bowie State University; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Johns Hopkins University; University of Melbourne; Murdoch Children's Research Institute; Victorian Clinical Genetics Services; Royal Children's Hospital Melbourne; Yale University; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Harvard University; Harvard Medical School
摘要：Mitochondrial DNA (mtDNA) has an important yet often overlooked role in health and disease. Constraint models quantify the removal of deleterious variation from the population by selection and represent powerful tools for identifying genetic variation that underlies human phenotypes1-4. However, nuclear constraint models are not applicable to mtDNA, owing to its distinct features. Here we describe the development of a mitochondrial genome constraint model and its application to the Genome Aggr...
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作者：Kim, Myunghee; Major, Matthew J.
作者单位：University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; Northwestern University; Feinberg School of Medicine; US Department of Veterans Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical Center; US Department of Veterans Affairs; Veterans Health Administration (VHA); Jesse Brown VA Medical Center
摘要：Wearable robots that assist leg movements could transform the lives of people with reduced mobility - but only if the devices can adapt in real time to support a vast range of human activities. Machine learning provides a way forward.
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作者：Schwaller, Fred
