作者：Wang, Yimeng; Cao, Siyu; Tone, Daisuke; Fujishima, Hiroshi; Yamada, Rikuhiro G.; Ohno, Rei-ichiro; Shi, Shoi; Matsuzawa, Kyoko; Yada, Saori; Kaneko, Mari; Sakamoto, Hirokazu; Onishi, Taichi; Ukai-Tadenuma, Maki; Ukai, Hideki; Hanashima, Carina; Hirose, Kenzo; Kiyonari, Hiroshi; Sumiyama, Kenta; Ode, Koji L.; Ueda, Hiroki R.
作者单位：University of Tokyo; RIKEN; Kurume University; RIKEN; University of Tokyo; Waseda University; RIKEN; University of Tsukuba; University of Tokyo; Nagoya University
摘要：The phosphorylation of synaptic proteins is a significant biochemical reaction that controls the sleep-wake cycle in mammals(1-3). Protein phosphorylation in vivo is reversibly regulated by kinases and phosphatases. In this study, we investigate a pair of kinases and phosphatases that reciprocally regulate sleep duration. First, we perform a comprehensive screen of protein kinaseA (PKA) and phosphoprotein phosphatase (PPP) family genes by generating 40 gene knockout mouse lines using prenatal ...
作者：Apseros, Andreas; Scagnoli, Valerio; Holler, Mirko; Guizar-Sicairos, Manuel; Gao, Zirui; Appel, Christian; Heyderman, Laura J.; Donnelly, Claire; Ihli, Johannes
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; United States Department of Energy (DOE); Brookhaven National Laboratory; Swiss Federal Institutes of Technology Domain; ETH Zurich; Max Planck Society; Hiroshima University; University of Oxford
摘要：The functionality of materials is determined by their composition(1-4) and microstructure, that is, the distribution and orientation of crystalline grains, grain boundaries and the defects within them(5,6). Until now, characterization techniques that map the distribution of grains, their orientation and the presence of defects have been limited to surface investigations, to spatial resolutions of a few hundred nanometres or to systems of thickness around 100nm, thus requiring destructive sampl...
作者：He, Fuchu; Aebersold, Ruedi; Baker, Mark S.; Bian, Xiuwu; Bo, Xiaochen; Chan, Daniel W.; Chang, Cheng; Chen, Luonan; Chen, Xiangmei; Chen, Yu-Ju; Cheng, Heping; Collins, Ben C.; Corrales, Fernando; Cox, Juergen; Weinan, E.; Van Eyk, Jennifer E.; Fan, Jia; Faridi, Pouya; Figeys, Daniel; Gao, George Fu; Gao, Wen; Gao, Zu-Hua; Goda, Keisuke; Goh, Wilson Wen Bin; Gu, Dongfeng; Guo, Changjiang; Guo, Tiannan; He, Yuezhong; Heck, Albert J. R.; Hermjakob, Henning; Hunter, Tony; Iyer, Narayanan Gopalakrishna; Jiang, Ying; Jimenez, Connie R.; Joshi, Lokesh; Kelleher, Neil L.; Li, Ming; Li, Yang; Lin, Qingsong; Liu, Cui Hua; Liu, Fan; Liu, Guang-Hui; Liu, Yansheng; Liu, Zhihua; Low, Teck Yew; Lu, Ben; Mann, Matthias; Meng, Anming; Moritz, Robert L.; Nice, Edouard; Ning, Guang; Omenn, Gilbert S.; Overall, Christopher M.; Palmisano, Giuseppe; Peng, Yaojin; Pineau, Charles; Poon, Terence Chuen Wai; Purcell, Anthony W.; Qiao, Jie; Reddel, Roger R.; Robinson, Phillip J.; Roncada, Paola; Sander, Chris; Sha, Jiahao; Song, Erwei; Srivastava, Sanjeeva; Sun, Aihua; Sze, Siu Kwan; Tang, Chao; Tang, Liujun; Tian, Ruijun; Vizcaino, Juan Antonio; Wang, Chanjuan; Wang, Chen; Wang, Xiaowen; Wang, Xinxing; Wang, Yan; Weiss, Tobias; Wilhelm, Mathias; Winkler, Robert; Wollscheid, Bernd; Wong, Limsoon; Xie, Linhai; Xie, Wei; Xu, Tao; Xu, Tianhao; Yan, Liying; Yang, Jing; Yang, Xiao; Yates, John; Yun, Tao; Zhai, Qiwei; Zhang, Bing; Zhang, Hui; Zhang, Lihua; Zhang, Lingqiang; Zhang, Pingwen; Zhang, Yukui; Zheng, Yu Zi; Zhong, Qing; Zhu, Yunping; Tan, Chris Soon Heng; Gao, Mingxia; Gao, Qiang; Gao, Yushun; Guo, Xuejiang; He, Jie; He, Jun; He, Qing-Yu; Hou, Jinlin; Huang, Canhua; Jia, Chenxi; Kuster, Bernhard; Li, Chaoying; Li, Dong; Li, Yanchang; Liu, Siqi; Liu, Xiaonan; Liu, Ya; Liu, Zhongyang; Lu, Haojie; Nie, Yongzhan; Okada, Mariko; Qian, Guojun; Qin, Hongqiang; Rao, Yu; Rao, Zihe; Ren, Xianwen; Ren, Yan; Shen, Feng; Shen, Lin; Su, Shicheng; Tan, Minjia; Tang, Ben Zhong; Tao, Sheng-Ce; Wang, Jian; Wang, Tong; Wei, Liming; Wong, Catherine C. L.; Xie, Xiaoliang Sunney; Xu, Li; Xu, Ping; Yang, Huanming; Yang, Jianjun; Ye, Mingliang; Ying, Wantao; Yu, Xiaobo; Yuan, Yaxiang; Zeng, Qingcun; Zhan, Qimin; Zhang, Xiaofei; Zhang, Xu; Zhang, Ying; Zhong, Nan-Shan; Zhou, Feng; Zhu, Yi; Zhang, Zemin
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Macquarie University; Army Medical University; Army Medical University; Johns Hopkins University; Johns Hopkins University; Johns Hopkins Medicine; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS; Academia Sinica - Taiwan; Peking University; Queens University Belfast; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro Nacional de Biotecnologia (CNB); Max Planck Society; Peking University; Cedars Sinai Medical Center; Fudan University; Hudson Institute of Medical Research; Monash University; University of Ottawa; University of Ottawa; Zhejiang University; Peking University; University of British Columbia; University of Tokyo; University of California System; University of California Los Angeles; Wuhan University; Nanyang Technological University; Southern University of Science & Technology; Westlake University; Westlake Laboratory; Westlake University; Utrecht University; Utrecht University; European Molecular Biology Laboratory (EMBL); European Bioinformatics Institute; Salk Institute; National Cancer Centre Singapore (NCCS); Vrije Universiteit Amsterdam; University of Amsterdam; Ollscoil na Gaillimhe-University of Galway; Northwestern University; University of Waterloo; National University of Singapore; Chinese Academy of Sciences; Institute of Microbiology, CAS; Chinese Academy of Sciences; Institute of Zoology, CAS; Yale University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Cancer Institute & Hospital - CAMS; Universiti Kebangsaan Malaysia; Central South University; Central South University; Max Planck Society; Tsinghua University; Institute for Systems Biology (ISB); Monash University; Shanghai Jiao Tong University; Shanghai Jiao Tong University; University of Michigan System; University of Michigan; University of British Columbia; Yonsei University; Universidade de Sao Paulo; Chinese Academy of Sciences; Institute of Zoology, CAS; Beijing Institute for Stem Cell & Regenerative Medicine; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Ecole des Hautes Etudes en Sante Publique (EHESP); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite de Rennes; University of Macau; Monash University; Monash University; Children's Medical Research Institute - Australia; University of Sydney; Magna Graecia University of Catanzaro; Harvard University; Harvard Medical School; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Nanjing Medical University; Sun Yat Sen University; Sun Yat Sen University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay; Brock University; Peking University; Southern University of Science & Technology; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; China-Japan Friendship Hospital; University of Zurich; University Zurich Hospital; University of Zurich; Technical University of Munich; Swiss Federal Institutes of Technology Domain; ETH Zurich; National University of Singapore; National University of Singapore; Guangzhou Laboratory; Guangzhou Medical University; Scripps Research Institute; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Baylor College of Medicine; Baylor College of Medicine; Johns Hopkins University; Johns Hopkins Medicine; Chinese Academy of Sciences; Dalian Institute of Chemical Physics, CAS; Peking University; Wuhan University; Fudan University; Chinese Academy of Sciences; Guangzhou Institute of Biomedicine & Health, CAS; Jinan University; Southern Medical University - China; Sichuan University; Sichuan University; Peking University; Air Force Medical University; University of Osaka; Naval Medical University; Tsinghua University; Tsinghua University; Changping Laboratory; Shanghai University of Traditional Chinese Medicine; Chinese Academy of Sciences; Shanghai Institute of Materia Medica, CAS; The Chinese University of Hong Kong, Shenzhen; Shanghai Jiao Tong University; Peking University; Sun Yat Sen University; Chinese Academy of Sciences; Academy of Mathematics & System Sciences, CAS; Chinese Academy of Sciences; Institute of Atmospheric Physics, CAS; Chinese People's Liberation Army General Hospital; Guangzhou Medical University; State Key Laboratory of Respiratory Disease
摘要：The human body contains trillions of cells, classified into specific cell types, with diverse morphologies and functions. In addition, cells of the same type can assume different states within an individual's body during their lifetime. Understanding the complexities of the proteome in the context of a human organism and its many potential states is a necessary requirement to understanding human biology, but these complexities can neither be predicted from the genome, nor have they been system...
作者：Beaver, Alexander K.; Keneskhanova, Zhibek; Cosentino, Raul O.; Weiss, Brian L.; Awuoche, Erick O.; Smallenberger, Gretchen M.; Buenconsejo, Gracyn Y.; Crilly, Nathan P.; Smith, Jaclyn E.; Hakim, Jill M. C.; Zhang, Bailin; Bobb, Bryce; Rijo-Ferreira, Filipa; Figueiredo, Luisa M.; Aksoy, Serap; Siegel, T. Nicolai; Mugnier, Monica R.
作者单位：Johns Hopkins University; Johns Hopkins Medicine; Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; University of Munich; University of Munich; Yale University
摘要：The protozoan parasite Trypanosoma brucei evades clearance by the host immune system through antigenic variation of its dense variant surface glycoprotein (VSG) coat, periodically 'switching' expression of the VSG using a large genomic repertoire of VSG-encoding genes(1-6). Recent studies of antigenic variation in vivo have focused near exclusively on parasites in the bloodstream(6-8), but research has shown that many, if not most, parasites reside in the interstitial spaces of tissues(9-13). ...
作者：Abramson, Josh; Adler, Jonas; Dunger, Jack; Evans, Richard; Green, Tim; Pritzel, Alexander; Ronneberger, Olaf; Willmore, Lindsay; Ballard, Andrew J.; Bambrick, Joshua; Bodenstein, Sebastian W.; Evans, David A.; Hung, Chia-Chun; O'Neill, Michael; Reiman, David; Tunyasuvunakool, Kathryn; Wu, Zachary; Zemgulyte, Akvile; Arvaniti, Eirini; Beattie, Charles; Bertolli, Ottavia; Bridgland, Alex; Cherepanov, Alexey; Congreve, Miles; Cowen-Rivers, Alexander I.; Cowie, Andrew; Figurnov, Michael; Fuchs, Fabian B.; Gladman, Hannah; Jain, Rishub; Khan, Yousuf A.; Low, Caroline M. R.; Perlin, Kuba; Potapenko, Anna; Savy, Pascal; Singh, Sukhdeep; Stecula, Adrian; Thillaisundaram, Ashok; Tong, Catherine; Yakneen, Sergei; Zhong, Ellen D.; Zielinski, Michal; Zidek, Augustin; Bapst, Victor; Kohli, Pushmeet; Jaderberg, Max; Hassabis, Demis; Jumper, John M.
