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作者：Islam, Mirazul; Yang, Yilin; Simmons, Alan J.; Shah, Vishal M.; Musale, Krushna Pavan; Xu, Yanwen; Tasneem, Naila; Chen, Zhengyi; Trinh, Linh T.; Molina, Paola; Ramirez-Solano, Marisol A.; Sadien, Iannish D.; Dou, Jinzhuang; Rolong, Andrea; Chen, Ken; Magnuson, Mark A.; Rathmell, Jeffrey C.; Macara, Ian G.; Winton, Douglas J.; Liu, Qi; Zafar, Hamim; Kalhor, Reza; Church, George M.; Shrubsole, Martha J.; Coffey, Robert J.; Lau, Ken S.
作者单位：Vanderbilt University; Vanderbilt University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University; University of Cambridge; CRUK Cambridge Institute; Cancer Research UK; University of Texas System; UTMD Anderson Cancer Center; Vanderbilt University; Vanderbilt University; Vanderbilt University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Kanpur; Johns Hopkins University; Harvard University; Harvard Medical School; Harvard University; Vanderbilt University; Vanderbilt University; Vanderbilt University; Vanderbilt University
摘要：Temporal ordering of cellular events offers fundamental insights into biological phenomena. Although this is traditionally achieved through continuous direct observations1,2, an alternative solution leverages irreversible genetic changes, such as naturally occurring mutations, to create indelible marks that enables retrospective temporal ordering3-5. Using a multipurpose, single-cell CRISPR platform, we developed a molecular clock approach to record the timing of cellular events and clonality ...
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作者：Ledford, Heidi
摘要：'Bricks' of DNA, some of which have chemical tags, could one day be an alternative to storing information electronically.
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作者：Naddaf, Miryam
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作者：Nozaki, Tadasu; Weiner, Beth; Kleckner, Nancy
作者单位：Harvard University
摘要：A central feature of meiosis is the pairing of homologous maternal and paternal chromosomes ('homologues') along their lengths(1-3). Recognition between homologues and their juxtaposition in space is mediated by axis-associated recombination complexes. Also, pairing must occur without entanglements among unrelated chromosomes. Here we examine homologue juxtaposition in real time by four-dimensional fluorescence imaging of tagged chromosomal loci at high spatio-temporal resolution in budding ye...
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作者：[Anonymous]
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作者：Lee, Jaeseok; Tsai, Victor C.; Hirth, Greg; Chatterjee, Avigyan; Trugman, Daniel T.
作者单位：Brown University; Nevada System of Higher Education (NSHE); University of Nevada Reno
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作者：Osterman, Ilya; Samra, Hadar; Rousset, Francois; Loseva, Elena; Itkin, Maxim; Malitsky, Sergey; Yirmiya, Erez; Millman, Adi; Sorek, Rotem
作者单位：Weizmann Institute of Science; Weizmann Institute of Science
摘要：Bacteria defend against phage infection through a variety of antiphage defence systems1. Many defence systems were recently shown to deplete cellular nicotinamide adenine dinucleotide (NAD(+)) in response to infection, by cleaving NAD(+) into ADP-ribose (ADPR) and nicotinamide2-7. It was demonstrated that NAD+ depletion during infection deprives the phage of this essential molecule and impedes phage replication. Here we show that a substantial fraction of phages possess enzymatic pathways allo...
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作者：Cowen, Ron
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作者：Dominguez-Andres, Jorge
作者单位：Radboud University Nijmegen
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作者：Vidler, Callum; Halwes, Michael; Kolesnik, Kirill; Segeritz, Philipp; Mail, Matthew; Barlow, Anders J.; Koehl, Emmanuelle M.; Ramakrishnan, Anand; Aguilar, Lilith M. Caballero; Nisbet, David R.; Scott, Daniel J.; Heath, Daniel E.; Crozier, Kenneth B.; Collins, David J.
作者单位：University of Melbourne; Florey Institute of Neuroscience & Mental Health; University of Melbourne; University of Melbourne; Melbourne Health; Royal Melbourne Hospital; University of Melbourne; St Vincent's Health; St Vincent's Hospital Melbourne; University of Melbourne; University of Melbourne; University of Melbourne; University of Melbourne; University of Melbourne
摘要：Additive manufacturing is an expanding multidisciplinary field encompassing applications including medical devices1, aerospace components2, microfabrication strategies3,4 and artificial organs5. Among additive manufacturing approaches, light-based printing technologies, including two-photon polymerization6, projection micro stereolithography7,8 and volumetric printing9-14, have garnered significant attention due to their speed, resolution or potential applications for biofabrication. Here we i...
