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作者:[Anonymous]
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作者:Gibney, Elizabeth
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作者:Ferretti, Luca; Wymant, Chris; Petrie, James; Tsallis, Daphne; Kendall, Michelle; Ledda, Alice; Di Lauro, Francesco; Fowler, Adam; Di Francia, Andrea; Panovska-Griffiths, Jasmina; Abeler-Doerner, Lucie; Charalambides, Marcos; Briers, Mark; Fraser, Christophe
作者单位:University of Oxford; University of Oxford; University of Warwick; UK Health Security Agency (UKHSA); Alan Turing Institute
摘要:How likely is it to become infected by SARS-CoV-2 after being exposed? Almost everyone wondered about this question during the COVID-19 pandemic. Contact-tracing apps1,2 recorded measurements of proximity3 and duration between nearby smartphones. Contacts-individuals exposed to confirmed cases-were notified according to public health policies such as the 2 m, 15 min guideline4,5, despite limited evidence supporting this threshold. Here we analysed 7 million contacts notified by the National He...
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作者:Kozlov, Max
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作者:Sukenikova, L.; Mallone, A.; Schreiner, B.; Ripellino, P.; Nilsson, J.; Stoffel, M.; Ulbrich, S. E.; Sallusto, F.; Latorre, D.
作者单位:Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Zurich; University Zurich Hospital; University of Zurich; Universita della Svizzera Italiana; University of Zurich; University Zurich Hospital; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Geneva; University of Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Universita della Svizzera Italiana
摘要:Guillain-Barre syndrome (GBS) is a rare heterogenous disorder of the peripheral nervous system, which is usually triggered by a preceding infection, and causes a potentially life-threatening progressive muscle weakness1. Although GBS is considered an autoimmune disease, the mechanisms that underlie its distinct clinical subtypes remain largely unknown. Here, by combining in vitro T cell screening, single-cell RNA sequencing and T cell receptor (TCR) sequencing, we identify autoreactive memory ...
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作者:Allentoft, Morten E.; Sikora, Martin; Refoyo-Martinez, Alba; Irving-Pease, Evan K.; Fischer, Anders; Barrie, William; Ingason, Andres; Stenderup, Jesper; Sjogren, Karl-Goran; Pearson, Alice; da Mota, Barbara Sousa; Paulsson, Bettina Schulz; Halgren, Alma; Macleod, Ruairidh; Jorkov, Marie Louise Schjellerup; Demeter, Fabrice; Sorensen, Lasse; Nielsen, Poul Otto; Henriksen, Rasmus A.; Vimala, Tharsika; McColl, Hugh; Margaryan, Ashot; Ilardo, Melissa; Vaughn, Andrew; Mortensen, Morten Fischer; Nielsen, Anne Birgitte; Hede, Mikkel Ulfeldt; Johannsen, Niels Norkjaer; Rasmussen, Peter; Vinner, Lasse; Renaud, Gabriel; Stern, Aaron; Jensen, Theis Zetner Trolle; Scorrano, Gabriele; Schroeder, Hannes; Lysdahl, Per; Ramsoe, Abigail Daisy; Skorobogatov, Andrei; Schork, Andrew Joseph; Rosengren, Anders; Ruter, Anthony; Outram, Alan; Timoshenko, Aleksey A.; Buzhilova, Alexandra; Coppa, Alfredo; Zubova, Alisa; Silva, Ana Maria; Hansen, Anders J.; Gromov, Andrey; Logvin, Andrey; Gotfredsen, Anne Birgitte; Nielsen, Bjarne Henning; Gonzalez-Rabanal, Borja; Lalueza-Fox, Carles; McKenzie, Catriona J.; Gaunitz, Charleen; Blasco, Concepcion; Liesau, Corina; Martinez-Labarga, Cristina; Pozdnyakov, Dmitri V.; Cuenca-Solana, David; Lordkipanidze, David O.; En'shin, Dmitri; Salazar-Garcia, Domingo C.; Price, T. Douglas; Boric, Dusan; Kostyleva, Elena; Veselovskaya, Elizaveta V.; Usmanova, Emma R.; Cappellini, Enrico; Petersen, Erik Brinch; Kannegaard, Esben; Radina, Francesca; Yediay, Fulya Eylem; Duday, Henri; Gutierrez-Zugasti, Igor; Merts, Ilya; Potekhina, Inna; Shevnina, Irina; Altinkaya, Isin; Guilaine, Jean; Hansen, Jesper; Tortosa, Joan Emili Aura; Zilhao, Joao; Vega, Jorge; Pedersen, Kristoffer Buck; Tunia, Krzysztof; Zhao, Lei; Mylnikova, Liudmila N.; Larsson, Lars; Metz, Laure; Yepiskoposyan, Levon; Pedersen, Lisbeth; Sarti, Lucia; Orlando, Ludovic; Slimak, Ludovic; Klassen, Lutz; Blank, Malou; Gonzalez-Morales, Manuel; Silvestrini, Mara; Vretemark, Maria; Nesterova, Marina S.; Rykun, Marina; Rolfo, Mario Federico; Szmyt, Marzena; Przybyla, Marcin; Calattini, Mauro; Sablin, Mikhail; Dobisikova, Miluse; Meldgaard, Morten; Johansen, Morten; Berezina, Natalia; Card, Nick; Saveliev, Nikolai A.; Poshekhonova, Olga; Rickards, Olga; Lozovskaya, Olga V.; Gabor, Oliver; Uldum, Otto Christian; Aurino, Paola; Kosintsev, Pavel; Courtaud, Patrice; Rios, Patricia; Mortensen, Peder; Lotz, Per; Persson, Per; Bangsgaard, Pernille; Damgaard, Peter de Barros; Petersen, Peter Vang; Martinez, Pilar Prieto; Wlodarczak, Piotr; Smolyaninov, Roman V.; Maring, Rikke; Menduina, Roberto; Badalyan, Ruben; Iversen, Rune; Turin, Ruslan; Vasilyev, Sergey; Wahlin, Sidsel; Borutskaya, Svetlana; Skochina, Svetlana; Sorensen, Soren Anker; Andersen, Soren H.; Jorgensen, Thomas; Serikov, Yuri B.; Molodin, Vyacheslav I.; Smrcka, Vaclav; Merts, Victor; Appadurai, Vivek; Moiseyev, Vyacheslav; Magnusson, Yvonne; Kjaer, Kurt H.; Lynnerup, Niels; Lawson, Daniel J.; Sudmant, Peter H.; Rasmussen, Simon; Korneliussen, Thorfinn Sand; Durbin, Richard; Nielsen, Rasmus; Delaneau, Olivier; Werge, Thomas; Racimo, Fernando; Kristiansen, Kristian; Willerslev, Eske
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作者:Chen, Siwei; Francioli, Laurent C.; Goodrich, Julia K.; Collins, Ryan L.; Kanai, Masahiro; Wang, Qingbo; Alfoeldi, Jessica; Watts, Nicholas A.; Vittal, Christopher; Gauthier, Laura D.; Poterba, Timothy; Wilson, Michael W.; Tarasova, Yekaterina; Phu, William; Grant, Riley; Yohannes, Mary T.; Koenig, Zan; Farjoun, Yossi; Banks, Eric; Donnelly, Stacey; Gabriel, Stacey; Gupta, Namrata; Ferriera, Steven; Tolonen, Charlotte; Novod, Sam; Bergelson, Louis; Roazen, David; Ruano-Rubio, Valentin; Covarrubias, Miguel; Llanwarne, Christopher; Petrillo, Nikelle; Wade, Gordon; Jeandet, Thibault; Munshi, Ruchi; Tibbetts, Kathleen; Abreu, Maria; Aguilar Salinas, Carlos A.; Ahmad, Tariq; Albert, Christine M.; Ardissino, Diego; Armean, Irina M.; Atkinson, Elizabeth G.; Atzmon, Gil; Barnard, John; Baxter, Samantha M.; Beaugerie, Laurent; Benjamin, Emelia J.; Benjamin, David; Boehnke, Michael; Bonnycastle, Lori L.; Bottinger, Erwin P.; Bowden, Donald W.; Bown, Matthew J.; Brand, Harrison; Brant, Steven; Brookings, Ted; Bryant, Sam; Calvo, Sarah E.; Campos, Hannia; Chambers, John C.; Chan, Juliana C.; Chao, Katherine R.; Chapman, Sinead; Chasman, Daniel I.; Chisholm, Rex; Cho, Judy; Chowdhury, Rajiv; Chung, Mina K.; Chung, Wendy K.; Cibulskis, Kristian; Cohen, Bruce; Connolly, Kristen M.; Correa, Adolfo; Cummings, Beryl B.; Dabelea, Dana; Danesh, John; Darbar, Dawood; Darnowsky, Phil; Denny, Joshua; Duggirala, Ravindranath; Dupuis, Josee; Ellinor, Patrick T.; Elosua, Roberto; Emery, James; England, Eleina; Erdmann, Jeanette; Esko, Tonu; Evangelista, Emily; Fatkin, Diane; Florez, Jose; Franke, Andre; Fu, Jack; Faerkkilae, Martti; Garimella, Kiran; Gentry, Jeff; Getz, Gad; Glahn, David C.; Glaser, Benjamin; Glatt, Stephen J.; Goldstein, David; Gonzalez, Clicerio; Groop, Leif; Gudmundsson, Sanna; Haessly, Andrea; Haiman, Christopher; Hall, Ira; Hanis, Craig L.; Harms, Matthew; Hiltunen, Mikko; Holi, Matti M.; Hultman, Christina M.; Jalas, Chaim; Kallela, Mikko; Kaplan, Diane; Kaprio, Jaakko; Kathiresan, Sekar; Kenny, Eimear E.; Kim, Bong-Jo; Kim, Young Jin; King, Daniel; Kirov, George; Kooner, Jaspal; Koskinen, Seppo; Krumholz, Harlan M.; Kugathasan, Subra; Kwak, Soo Heon; Laakso, Markku; Lake, Nicole; Langsford, Trevyn; Laricchia, Kristen M.; Lehtimaeki, Terho; Lek, Monkol; Lipscomb, Emily; Loos, Ruth J. F.; Lu, Wenhan; Lubitz, Steven A.; Luna, Teresa Tusie; Ma, Ronald C. W.; Marcus, Gregory M.; Marrugat, Jaume; Mattila, Kari M.; Mccarroll, Steven; Mccarthy, Mark I.; Mccauley, Jacob L.; Mcgovern, Dermot; Mcpherson, Ruth; Meigs, James B.; Melander, Olle; Metspalu, Andres; Meyers, Deborah; Minikel, Eric V.; Mitchell, Braxton D.; Mootha, Vamsi K.; Naheed, Aliya; Nazarian, Saman; Nilsson, Peter M.; O'Donovan, Michael C.; Okada, Yukinori; Ongur, Dost; Orozco, Lorena; Owen, Michael J.; Palmer, Colin; Palmer, Nicholette D.; Palotie, Aarno; Park, Kyong Soo; Pato, Carlos; Pulver, Ann E.; Rader, Dan; Rahman, Nazneen; Reiner, Alex; Remes, Anne M.; Rhodes, Dan; Rich, Stephen; Rioux, John D.; Ripatti, Samuli; Roden, Dan M.; Rotter, Jerome I.; Sahakian, Nareh; Saleheen, Danish; Salomaa, Veikko; Saltzman, Andrea; Samani, Nilesh J.; Samocha, Kaitlin E.; Sanchis-Juan, Alba; Scharf, Jeremiah; Schleicher, Molly; Schunkert, Heribert; Schoenherr, Sebastian; Seaby, Eleanor G.; Shah, Svati H.; Shand, Megan; Sharpe, Ted; Shoemaker, Moore B.; Shyong, Tai; Silverman, Edwin K.; Singer-Berk, Moriel; Sklar, Pamela; Smith, Jonathan T.; Smith, J. Gustav; Soininen, Hilkka; Sokol, Harry; Son, Rachel G.; Soto, Jose; Spector, Tim; Stevens, Christine; Stitziel, Nathan O.; Sullivan, Patrick F.; Suvisaari, Jaana; Tai, E. Shyong; Taylor, Kent D.; Teo, Yik Ying; Tsuang, Ming; Tuomi, Tiinamaija; Turner, Dan; Tusie-Luna, Teresa; Vartiainen, Erkki; Vawter, Marquis; Wang, Lily; Wang, Arcturus; Ware, James S.; Watkins, Hugh; Weersma, Rinse K.; Weisburd, Ben; Wessman, Maija; Whiffin, Nicola; Wilson, James G.; Xavier, Ramnik J.; O'Donnell-Luria, Anne; Solomonson, Matthew; Seed, Cotton; Martin, Alicia R.; Talkowski, Michael E.; Rehm, Heidi L.; Daly, Mark J.; Tiao, Grace; Neale, Benjamin M.; Macarthur, Daniel G.; Karczewski, Konrad J.
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作者:Cristofari, Gael
作者单位:Universite Cote d'Azur; Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm)
摘要:LINE-1 DNA elements self-duplicate, inserting the copy into new regions of the genome - a key process in chromosome evolution. Structures of the machinery that performs this process in humans are now reported.
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作者:Callaway, Ewen
摘要:Researchers have doubted how useful the AI protein-structure tool will be in discovering medicines - now they are learning how to deploy it effectively.
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作者:Fang, Wensheng; Guo, Wei; Lu, Ruihu; Yan, Ya; Liu, Xiaokang; Wu, Dan; Li, Fu Min; Zhou, Yansong; He, Chaohui; Xia, Chenfeng; Niu, Huiting; Wang, Sicong; Liu, Youwen; Mao, Yu; Zhang, Chengyi; You, Bo; Pang, Yuanjie; Duan, Lele; Yang, Xuan; Song, Fei; Zhai, Tianyou; Wang, Guoxiong; Guo, Xingpeng; Tan, Bien; Yao, Tao; Wang, Ziyun; Xia, Bao Yu
作者单位:Huazhong University of Science & Technology; University of Auckland; Chinese Academy of Sciences; Shanghai Institute of Ceramics, CAS; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Huazhong University of Science & Technology; Southern University of Science & Technology; Southern University of Science & Technology; Chinese Academy of Sciences; Shanghai Advanced Research Institute, CAS; Chinese Academy of Sciences; Dalian Institute of Chemical Physics, CAS
摘要:Electrolysis that reduces carbon dioxide (CO2) to useful chemicals can, in principle, contribute to a more sustainable and carbon-neutral future(1,2,3,4,5,6). However, it remains challenging to develop this into a robust process because efficient conversion typically requires alkaline conditions in which CO2 precipitates as carbonate, and this limits carbon utilization and the stability of the system(7,8,9,10,11,12). Strategies such as physical washing, pulsed operation and the use of dipolar ...